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Your search keyword '"Wines, Bruce D"' showing total 13 results
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13 results on '"Wines, Bruce D"'

2. Antibody glycosylation correlates with disease progression in SIV‐Mycobacterium tuberculosis coinfected cynomolgus macaques

Author

Haycroft, Ebene R, primary, Damelang, Timon, additional, Lopez, Ester, additional, Rodgers, Mark A, additional, Wines, Bruce D, additional, Hogarth, Mark, additional, Ameel, Cassaundra L, additional, Kent, Stephen J, additional, Scanga, Charles A, additional, O'Connor, Shelby L, additional, and Chung, Amy W, additional

Published
2023
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3. RNA sequencing of single allergen‐specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect

Author

McKenzie, Craig I., primary, Varese, Nirupama, additional, Aui, Pei Mun, additional, Reinwald, Simone, additional, Wines, Bruce D., additional, Hogarth, P. Mark, additional, Thien, Francis, additional, Hew, Mark, additional, Rolland, Jennifer M., additional, O'Hehir, Robyn E., additional, and van Zelm, Menno C., additional

Published
2022
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5. Epidemic thunderstorm asthma susceptibility from sensitization to ryegrass (Lolium perenne) pollen and major allergen Lol p 5

Author

Hew, Mark, primary, Lee, Joy, additional, Varese, Nirupama, additional, Aui, Pei M., additional, McKenzie, Craig I., additional, Wines, Bruce D., additional, Aumann, Heather, additional, Rolland, Jennifer M., additional, Mark Hogarth, Phillip, additional, van Zelm, Menno C., additional, and O’Hehir, Robyn E., additional

Published
2020
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7. Harnessing the immune system via Fc gamma R function in immune therapy : a pathway to next-gen mAbs

Author

Chenoweth, Alicia M., Wines, Bruce D., Anania, Jessica, Hogarth, P., Chenoweth, Alicia M., Wines, Bruce D., Anania, Jessica, and Hogarth, P.

Abstract

The human fragment crystallizable (Fc)gamma receptor (R) interacts with antigen-complexed immunoglobulin (Ig)G ligands to both activate and modulate a powerful network of inflammatory host-protective effector functions that are key to the normal physiology of immune resistance to pathogens. More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent Fc gamma R-mediated effector systems to varying degrees. This is most evident for antibodies targeting cancer cells inducing antibody-dependent killing or phagocytosis but is also true to some degree for the mAbs that neutralize or remove small macromolecules such as cytokines or other Igs. The use of mAb therapeutics has also revealed a "scaffolding" role for Fc gamma R which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. The still unmet therapeutic need in many cancers, inflammatory diseases or emerging infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires increased effort on the development of improved and novel mAbs. A more mature appreciation of the immunobiology of individual Fc gamma R function and the complexity of the relationships between Fc gamma Rs and antibodies is fueling efforts to develop more potent "next-gen" therapeutic antibodies. Such development strategies now include focused glycan or protein engineering of the Fc to increase affinity and/or tailor specificity for selective engagement of individual activating Fc gamma Rs or the inhibitory Fc gamma RIIb or alternatively, for the ablation of Fc gamma R interaction altogether. This review touches on recent aspects of Fc gamma R and IgG immunobiology and its relationship with the present and future actions of therapeutic mAbs.

Published
2020
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13. Distinctive expression of interleukin-23 receptor subunits on human Th17 and γδ T cells.

Author

Wines BD, Yap ML, Powell MS, Tan PS, Ko KK, Orlowski E, and Hogarth PM

Subjects
Animals, Antibodies, Monoclonal metabolism, Cells, Cultured, Humans, Immunologic Memory, Mice, Interleukin-12 Receptor beta 1 Subunit metabolism, Protein Subunits metabolism, Receptors, Antigen, T-Cell, gamma-delta metabolism, Receptors, Interleukin metabolism, Th17 Cells metabolism
Abstract

The interleukin-23 (IL-23) pathway, T helper 17 (Th17) cells and γδ T cells, which respond to IL-23, have major pro-inflammatory roles. We have used unique IL-23 receptor (IL-23R) subunit-specific monoclonal antibodies, X67 and X68, and IL-12 receptor beta-1 subunit (IL-12Rβ1) expression levels to evaluate the IL-23R complex on CD4 αβ TCR Th17 cells and on γδ T cells. Both IL-23R and IL-12Rβ1 subunits constitute the functional IL-23R. Expression of the IL-23R subunit by cultured Th17 cells was heterogeneous. Th17 cells expressed consistent high levels of the IL-12Rβ1 subunit, which appeared a better predictor of responsiveness to IL-23 than the expression of the IL-23R subunit. Moreover, sorting memory CD4 T cells by high IL-12Rβ1 expression selectively enriched cells committed to IL-17 production from the blood. IL-23R expression was also observed on freshly isolated and cultured γδ T cells and the cultured γδ T cells were not responsive to IL-23.

Published
2017
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