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16 results on '"Wong, Vincent Kam Wai"'

1. Combining computational and experimental evidence on the activity of antimalarial drugs on papain‐like protease of SARS‐CoV ‐2: A repurposing study

Author

Ribaudo, Giovanni, primary, Yun, Xiaoyun, additional, Ongaro, Alberto, additional, Oselladore, Erika, additional, Ng, Jerome P. L., additional, Haynes, Richard K., additional, Law, Betty Yuen Kwan, additional, Memo, Maurizio, additional, Wong, Vincent Kam Wai, additional, Coghi, Paolo, additional, and Gianoncelli, Alessandra, additional

Published
2022
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3. Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes

Author

Coghi, Paolo, primary, Yaremenko, Ivan A., additional, Prommana, Parichat, additional, Wu, Jia Ning, additional, Zhang, Rui Long, additional, Ng, Jerome P. L., additional, Belyakova, Yulia Yu., additional, Law, Betty Yuen Kwan, additional, Radulov, Peter S., additional, Uthaipibull, Chairat, additional, Wong, Vincent Kam Wai, additional, and Terent'ev, Alexander O., additional

Published
2022
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4. Front Cover: Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P‐Glycoprotein ABCB5 (ChemMedChem 13/2020)

Author

Yaremenko, Ivan A., primary, Coghi, Paolo, additional, Prommana, Parichat, additional, Qiu, Congling, additional, Radulov, Peter S., additional, Qu, Yuanqing, additional, Belyakova, Yulia Yu., additional, Zanforlin, Enrico, additional, Kokorekin, Vladimir A., additional, Wu, Yuki Yu Jun, additional, Fleury, Fabrice, additional, Uthaipibull, Chairat, additional, Wong, Vincent Kam Wai, additional, and Terent'ev, Alexander O., additional

Published
2020
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5. Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P‐Glycoprotein ABCB5

Author

Yaremenko, Ivan A., primary, Coghi, Paolo, additional, Prommana, Parichat, additional, Qiu, Congling, additional, Radulov, Peter S., additional, Qu, Yuanqing, additional, Belyakova, Yulia Yu., additional, Zanforlin, Enrico, additional, Kokorekin, Vladimir A., additional, Wu, Yuki Yu Jun, additional, Fleury, Fabrice, additional, Uthaipibull, Chairat, additional, Wong, Vincent Kam Wai, additional, and Terent'ev, Alexander O., additional

Published
2020
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6. Ca 2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats

Author

Wong, Vincent Kam Wai, primary, Qiu, Congling, additional, Xu, Su‐Wei, additional, Law, Betty Yuen Kwan, additional, Zeng, Wu, additional, Wang, Hui, additional, Michelangeli, Francesco, additional, Dias, Ivo Ricardo De Seabra Rodrigues, additional, Qu, Yuan Qing, additional, Chan, Tsz Wai, additional, Han, Yu, additional, Zhang, Ni, additional, Mok, Simon Wing Fai, additional, Chen, Xi, additional, Yu, Lu, additional, Pan, Hudan, additional, Hamdoun, Sami, additional, Efferth, Thomas, additional, Yu, Wen Jing, additional, Zhang, Wei, additional, Li, Zheng, additional, Xie, Yuesheng, additional, Luo, Riqiang, additional, Jiang, Quan, additional, and Liu, Liang, additional

Published
2019
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7. Corrigendum: Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity

Author

Coghi, Paolo, primary, Yaremenko, Ivan A., additional, Prommana, Parichat, additional, Radulov, Peter S., additional, Syroeshkin, Mikhail A., additional, Wu, Yu Jun, additional, Gao, Jia Ying, additional, Gordillo, Floria M., additional, Mok, Simon, additional, Wong, Vincent Kam Wai, additional, Uthaipibull, Chairat, additional, and Terent'ev, Alexander O., additional

Published
2018
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8. Innenrücktitelbild: Selective Inhibition of Lysine‐Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple‐Negative Breast Cancer Therapy (Angew. Chem. 40/2018)

Author

Yang, Guan‐Jun, primary, Wang, Wanhe, additional, Mok, Simon Wing Fai, additional, Wu, Chun, additional, Law, Betty Yuen Kwan, additional, Miao, Xiang‐Min, additional, Wu, Ke‐Jia, additional, Zhong, Hai‐Jing, additional, Wong, Chun‐Yuen, additional, Wong, Vincent Kam Wai, additional, Ma, Dik‐Lung, additional, and Leung, Chung‐Hang, additional

Published
2018
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9. Inside Back Cover: Selective Inhibition of Lysine‐Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple‐Negative Breast Cancer Therapy (Angew. Chem. Int. Ed. 40/2018)

Author

Yang, Guan‐Jun, primary, Wang, Wanhe, additional, Mok, Simon Wing Fai, additional, Wu, Chun, additional, Law, Betty Yuen Kwan, additional, Miao, Xiang‐Min, additional, Wu, Ke‐Jia, additional, Zhong, Hai‐Jing, additional, Wong, Chun‐Yuen, additional, Wong, Vincent Kam Wai, additional, Ma, Dik‐Lung, additional, and Leung, Chung‐Hang, additional

Published
2018
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10. Selective Inhibition of Lysine‐Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple‐Negative Breast Cancer Therapy

Author

Yang, Guan‐Jun, primary, Wang, Wanhe, additional, Mok, Simon Wing Fai, additional, Wu, Chun, additional, Law, Betty Yuen Kwan, additional, Miao, Xiang‐Min, additional, Wu, Ke‐Jia, additional, Zhong, Hai‐Jing, additional, Wong, Chun‐Yuen, additional, Wong, Vincent Kam Wai, additional, Ma, Dik‐Lung, additional, and Leung, Chung‐Hang, additional

Published
2018
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11. Front Cover: Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity (ChemMedChem 9/2018)

Author

Coghi, Paolo, primary, Yaremenko, Ivan A., additional, Prommana, Parichat, additional, Radulov, Peter S., additional, Syroeshkin, Mikhail A., additional, Wu, Yu Jun, additional, Gao, Jia Ying, additional, Gordillo, Floria M., additional, Mok, Simon, additional, Wong, Vincent Kam Wai, additional, Uthaipibull, Chairat, additional, and Terent'ev, Alexander O., additional

Published
2018
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12. Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity

Author

Coghi, Paolo, primary, Yaremenko, Ivan A., additional, Prommana, Parichat, additional, Radulov, Peter S., additional, Syroeshkin, Mikhail A., additional, Wu, Yu Jun, additional, Gao, Jia Ying, additional, Gordillo, Floria M., additional, Mok, Simon, additional, Wong, Vincent Kam Wai, additional, Uthaipibull, Chairat, additional, and Terent'ev, Alexander O., additional

Published
2018
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16. Thonningianin A from Penthorum chinense Pursh as a targeted inhibitor of Alzheimer's disease-related β-amyloid and Tau proteins.

Author

Yu L, Wang H, Yao Q, Li K, Qu L, Tang B, Zeng W, Qiao G, Tang Y, Hu G, Hu G, Wong VK, Wang Q, Qin D, Wu J, Zhou X, Sun X, Law BY, and Wu A

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by complex pathogenesis mechanisms. Among these, β-amyloid plaques and hyperphosphorylated Tau protein tangles have been identified as significant contributors to neuronal damage. This study investigates thonningianin A (TA) from Penthorum chinense Pursh (PCP) as a potential inhibitor targeting these pivotal proteins in AD progression. The inhibitory potential of PCP and TA on Aβ fibrillization was initially investigated. Subsequently, ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry and biolayer interferometry were employed to determine TA's affinity for both Aβ and Tau. The inhibitory effects of TA on the levels and cytotoxicity of AD-related proteins were then assessed. In 3xTg-AD mice, the therapeutic potential of TA was evaluated. Additionally, the molecular interactions between TA and either Aβ or Tau were explored using molecular docking. We found that PCP-total ethanol extract and TA significantly inhibited Aβ fibrillization. Additionally, TA demonstrated strong affinity to Aβ and Tau, reduced levels of amyloid precursor protein and Tau, and alleviated mitochondrial distress in PC-12 cells. In 3xTg-AD mice, TA improved cognition, reduced Aβ and Tau pathology, and strengthened neurons. Moreover, molecular analyses revealed efficient binding of TA to Aβ and Tau. In conclusion, TA, derived from PCP, shows significant neuroprotection against AD proteins, highlighting its potential as an anti-AD drug candidate., (© 2023 John Wiley & Sons Ltd.)

Published
2024
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