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31 results on '"Wu, Tiantian"'

30. Effect of curcumin on regulatory B cells in chronic colitis mice involving TLR/MyD88 signaling pathway.

Author

Huang J, Wu T, Zhong Y, Huang J, Kang Z, Zhou B, Zhao H, and Liu D

Subjects
Mice, Animals, Interleukin-1 Receptor-Associated Kinases metabolism, Interleukin-1 Receptor-Associated Kinases pharmacology, Interleukin-1 Receptor-Associated Kinases therapeutic use, Myeloid Differentiation Factor 88 metabolism, Signal Transduction, Colon, NF-kappa B metabolism, Dextran Sulfate adverse effects, Disease Models, Animal, B-Lymphocytes, Regulatory metabolism, B-Lymphocytes, Regulatory pathology, Curcumin pharmacology, Curcumin therapeutic use, Colitis chemically induced, Colitis drug therapy, Colitis, Ulcerative chemically induced, Colitis, Ulcerative drug therapy, Colitis, Ulcerative pathology
Abstract

Curcumin (Cur) is a natural active phenolic compound extracted from the root of Curcuma Longa L. It has anti-inflammatory, anti-tumor and other pharmacological activities, and is commonly used to treat ulcerative colitis (UC). However, it is not clear whether curcumin regulates the function and differentiation of Breg cells to treat UC. In this study, mice with chronic colitis were induced by dextran sulfate sodium (DSS), and treated with curcumin for 12 days. Curcumin effectively improved the body weight, colonic weight, colonic length, decreased colonic weight index and pathological injury score under colonoscopy in mice with chronic colitis, and significantly inhibited the production of IL-1β, IL-6, IL-33, CCL-2, IFN-γ, TNF-α, and promoted the secretion of IL-4, IL-10, IL-13 and IgA. Importantly, curcumin markedly upregulated CD3 - CD19 + CD1d + , CD3 - CD19 + CD25 + , CD3 - CD19 + Foxp3 + Breg cells level and significantly down-regulated CD3 - CD19 + PD-L1 + , CD3 - CD19 + tim-1 + , CD3 - CD19 + CD27 + Breg cells level. In addition, our results also showed that curcumin observably inhibited TLR2, TLR4, TLR5, MyD88, IRAK4, p-IRAK4, NF-κB P65, IRAK1, TRAF6, TAB1, TAB2, TAK1, MKK3, MKK6, p38MAPK, p-p38MAPK and CREB expression in TLR/MyD88 signaling pathway. These results suggest that curcumin can regulate the differentiation and function of Breg cell to alleviate DSS-induced colitis, which may be realized by inhibiting TLR/MyD88 pathway., (© 2022 John Wiley & Sons Ltd.)

Published
2023
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31. Dengue fever and dengue virus in the People's Republic of China.

Author

Wu T, Wu Z, and Li YP

Subjects
Animals, China epidemiology, Humans, Mosquito Vectors, Aedes, Dengue, Dengue Virus genetics, Severe Dengue
Abstract

Infection with dengue virus (DENV) leads to symptoms variable from dengue fever to severe dengue, which has posed a huge socioeconomic and disease burden to the world population, particularly in tropical and subtropical regions. To date, four serotypes of DENV (DENV-1 to DENV-4) have been identified to sustain the transmission cycle in humans. In the past decades, dengue incidences have become more frequent, and four serotypes and various genotypes have been identified in PR China. Several large-scale dengue outbreaks and frequent local endemics occurred in the southern and coastal provinces, and the imported dengue cases accounted primarily for the initiation of the epidemics. No antiviral drug exists for dengue, and no vaccine has been approved to use in PR China, however strategies including public awareness, national reporting system of infectious diseases and public health emergencies, vector mosquito control, personal protection, and improved environmental sanitation have greatly reduced dengue prevalence. Some new technologies in vector mosquito control are emerging and being applied for dengue control. China's territory spans tropical, subtropical, and temperate climates, hence understanding the dengue status in China will be of beneficial for the global prevention and control of dengue. Here, we review the dengue status in PR China for the past decades and the strategies emerging for dengue control., (© 2021 John Wiley & Sons Ltd.)

Published
2022
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