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47. Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis.

Author

Chang KC, Su MJ, Peng YI, Shao CC, Wu YC, and Tseng YZ

Subjects
Analysis of Variance, Animals, Anti-Arrhythmia Agents pharmacology, Blood Pressure drug effects, Cardiac Output drug effects, Dose-Response Relationship, Drug, Heart Rate drug effects, Male, Quinidine pharmacology, Rats, Rats, Inbred WKY, Stroke Volume drug effects, Aporphines pharmacology, Ventricular Function, Left drug effects
Abstract

1. In a recent in vivo study, liriodenine, an aporphine alkaloid, has been identified as a prominent anti-arrhythmic agent that can prevent rats' sudden deaths, even at the dose as low as 10(-7) g kg(-1). The aim of this study was to determine whether liriodenine at its effective anti-arrhythmic dose of 10(-7) g kg(-1) had effects on the left ventricular (LV)-arterial coupling in Wistar rats. 2. LV pressure and ascending aortic flow signals were recorded to construct the ventricular and arterial end-systolic pressure-stroke volume relationships to calculate LV end-systolic elastance (E(es)) and effective arterial volume elastance (E(a)), respectively. The optimal afterload (Q(load)) determined by the ratio of E(a) to E(es) was used to measure the optimality of energy transmission from the left ventricle to the arterial system. 3. Liriodenine at the dose of 10(-7) g kg(-1) showed no significant changes in basal heart rate (HR), cardiac output (CO), LV end-systolic pressure (P(es)), E(a), E(es), and Q(load). 4. By contrast, liriodenine at the dose of 10(-6) g kg(-1) produced a significant fall of 2.0% in HR and a significant rise of 5.8% in CO, but no significant change in P(es). Moreover, liriodenine administration of 10(-6) g kg(-1) to rats significantly decreased E(es) by 8.5% and E(a) by 10.6%, but did not change Q(load). 5. We conclude that liriodenine at the dose of 10(-7) g kg(-1) has no effects on the mechanical properties of the heart and the vasculature and the matching condition for the left ventricle coupled to its vasculature in rats. Even at 10 times the effective anti-arrhythmic dose, liriodenine shows no effects on the efficiency of energy transferred from the left ventricle to the arterial system.

Published
2001
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48. Prenatal diagnosis of anophthalmos with limb-body wall complex.

Author

Wu YC, Yang ML, and Yuan CC

Subjects
Adult, Amniocentesis, Amniotic Band Syndrome diagnosis, Amniotic Band Syndrome pathology, Female, Fetal Death etiology, Fetal Death pathology, Gestational Age, Humans, Infant, Newborn, Karyotyping, Abnormalities, Multiple diagnostic imaging, Anophthalmos diagnostic imaging, Limb Deformities, Congenital diagnostic imaging, Ultrasonography, Prenatal
Published
2000

49. Successful management of malignant hyperthermia susceptibility during cesarean hysterectomy for postpartum hemorrhage.

Author

Wu YC, Ho CM, Tsou MY, Hung JH, Yuan CC, Lee TY, and Ng HT

Subjects
Adult, Anesthesia, Obstetrical adverse effects, Diagnosis, Differential, Disease Susceptibility, Female, Humans, Malignant Hyperthermia diagnosis, Malignant Hyperthermia etiology, Monitoring, Intraoperative, Postpartum Hemorrhage complications, Pregnancy, Anesthesia, Obstetrical methods, Cesarean Section, Hysterectomy, Malignant Hyperthermia prevention & control, Postpartum Hemorrhage surgery
Published
1999

50. Mixed-valence compound-based biosensor.

Author

Lin MS, Wu YC, and Jan BI

Subjects
Biotechnology, Cobalt, Electrochemistry, Electron Transport, Ferrocyanides, Glucose analysis, Kinetics, Biosensing Techniques
Abstract

A cobalt(II)hexacyanoferrate-based biosensor has been prepared simply by codeposition of an enzyme, together with the electrochemical formation of a cobalt (II)hexacyanoferrate compound electrochemically. The compound can be generated at a constant potential of -0.05 V (vs. Ag/AgCl). This compound possesses the catalytic property of reducing hydrogen peroxide to water at the operating potential of 0.0 V vs. Ag/AgCl. The mixed-valence compound-based biosensor possesses an unique interference-independent feature, which is important for biomedical application; this feature is attributed to the low overvoltage characteristic of cobalt (II)hexacyanoferrate. The electrochemical glucose biosensor responds to a series of glucose injections with linearity up to 5 mM (with correlation coefficient R = 0.9999) and the sensitivity of the linear portion is 733 nA/(cm2 x mM). The detection limit is 2 x 10(-6)M (S/N = 3). Both the potential-dependent electron transfer rate constant and the apparent Michaelis-Menten constant were studied in rotating disk experiments. The apparent Michaelis-Menten constant, Km' calculated from the slope of the "Lineweaver-Burke" type reciprocal plot is 28 mM. A fast-response characteristic is observed in the rotating disk experiment and the 95% response time is 14.5 sec. No response was observed from the addition of either 2 x 10(-4)M galactose, acetaminophen, ascorbic acid, uric acid, cysteine, tyrosine, dopamine, or 1,4-dihydroxyquinone in the absence and/or in the presence of 5 x 10(-4)M glucose., (Copyright 1999 John Wiley & Sons, Inc.)

Published
1999
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