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9 results on '"Wu, Yiting"'

4. Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy (Adv. Mater. 37/2021)

Author

Liu, Chuang, primary, Sun, Shan, additional, Feng, Qiang, additional, Wu, Gongwei, additional, Wu, Yiting, additional, Kong, Na, additional, Yu, Zhangsen, additional, Yao, Junlie, additional, Zhang, Xingcai, additional, Chen, Wei, additional, Tang, Zhongmin, additional, Xiao, Yufen, additional, Huang, Xiangang, additional, Lv, Aman, additional, Yao, Chenyang, additional, Cheng, Haibo, additional, Wu, Aiguo, additional, Xie, Tian, additional, and Tao, Wei, additional

Published
2021
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5. Zn 2+ Doped Ultrasmall Prussian Blue Nanotheranostic Agent for Breast Cancer Photothermal Therapy under MR Imaging Guidance

Author

Shou, Pingbo, primary, Yu, Zhangsen, additional, Wu, Yiting, additional, Feng, Qiang, additional, Zhou, Bangyi, additional, Xing, Jie, additional, Liu, Chuang, additional, Tu, Jinqing, additional, Akakuru, Ozioma Udochukwu, additional, Ye, Zhiqiu, additional, Zhang, Xiaojuan, additional, Lu, Zhenbo, additional, Zhang, Luyun, additional, and Wu, Aiguo, additional

Published
2019
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6. Zn 2+ Doped Ultrasmall Prussian Blue Nanotheranostic Agent for Breast Cancer Photothermal Therapy under MR Imaging Guidance

Author

Ye Zhiqiu, Feng Qiang, Aiguo Wu, Jinqing Tu, Chuang Liu, Bangyi Zhou, Luyun Zhang, Ozioma Udochukwu Akakuru, Wu Yiting, Yu Zhangsen, Shou Pingbo, Zhenbo Lu, Xiaojuan Zhang, and Jie Xing

Subjects
Prussian blue, Biodistribution, Chemistry, Doping, Biomedical Engineering, Pharmaceutical Science, 02 engineering and technology, Photothermal therapy, 010402 general chemistry, 021001 nanoscience & nanotechnology, medicine.disease, 01 natural sciences, Mr imaging, 0104 chemical sciences, Biomaterials, chemistry.chemical_compound, Breast cancer, Nuclear magnetic resonance, Killing rate, In vivo, medicine, 0210 nano-technology
Abstract

Prussian blue nanoprobes are widely studied and applied in tumor photothermal therapy (PTT) and magnetic resonance imaging (MRI), due to their low toxicity and excellent in vivo performance. However, the sizes of hitherto reported Prussian blue nanoprobes are generally larger than 50 nm, which greatly influence cell phagocytosis, in vivo circulation, and biodistribution. In this work, a novel method of doping zinc ions is used to control the size of Prussian blue nanoprobes. Consequently, the performances of the nanoprobes in PTT and MRI are both significantly improved. The results show that the minimum size of Prussian blue nanoprobes achieved by doping 10% zinc ions (abbreviated as SPBZn(10%)) is 3.8 ± 0.90 nm, and the maximum specific absorption coefficient, photothermal conversion efficiency, and longitudinal relaxation rates are 1.78 L g-1 cm-1 , 47.33%, and 18.40 mm-1 s-1 , respectively. In addition, the SPBZn(10%) nanoprobes provide excellent PTT efficacy on 4T1 tumor cells (killing rate: 90.3%) and breast cancer model (tumor inhibition rate: 69.4%). Toxicological experiment results show that the SPBZn(n%) nanoprobes exhibit no obvious in vitro cytotoxicity and they can be used safely in mice at doses below 100 mg kg-1 . Therefore, SPBZn(10%) nanoprobes can potentially be used for effective cancer theranostics.

Published
2019

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