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Start Over Author "Wu, Zi-Cong" Publisher wiley
2 results on '"Wu, Zi-Cong"'

2. Mesenchymal stromal cells‐derived small extracellular vesicles modulate DC function to suppress Th2 responses via IL‐10 in patients with allergic rhinitis

Author

Peng, Ya‐Qi, Wu, Zi‐Cong, Xu, Zhi‐Bin, Fang, Shu‐Bin, Chen, De‐Hua, Zhang, Hong‐Yu, Liu, Xiao‐Qing, He, Bi‐Xin, Chen, Dong, Akdis, Cezmi A, Fu, Qing‐Ling, University of Zurich, and Fu, Qing‐Ling

Subjects
2403 Immunology, Immunology, Cell Differentiation, Mesenchymal Stem Cells, 610 Medicine & health, Dendritic Cells, Rhinitis, Allergic, Extracellular Vesicles, 10183 Swiss Institute of Allergy and Asthma Research, Leukocytes, Mononuclear, 2723 Immunology and Allergy, Humans, Immunology and Allergy, Cells, Cultured
Abstract

Mesenchymal stromal cells (MSCs) are well known for their immunoregulatory roles on allergic inflammation particularly by acting on T cells, B cells, and dendritic cells (DCs). MSC-derived small extracellular vesicles (MSC-sEV) are increasingly considered as one of the main factors for the effects of MSCs on immune responses. However, the effects of MSC-sEV on DCs in allergic diseases remain unclear. MSC-sEV were prepared from the induced pluripotent stem cells (iPSC)-MSCs by anion-exchange chromatography, and were characterized with the size, morphology, and specific markers. Human monocyte-derived DCs were generated and cultured in the presence of MSC-sEV to differentiate the so-called sEV-immature DCs (sEV-iDCs) and sEV-mature DCs (sEV-mDCs), respectively. The phenotypes and the phagocytic ability of sEV-iDCs were analyzed by flow cytometry. sEV-mDCs were co-cultured with isolated CD4

Published
2022

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