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Abstract Mindfulness and self‐regulation practice have shown benefits in reducing emotional disorders and improving cognitive outcomes. This study uses ecological momentary assessment (EMA) to examine time‐lagged associations of momentary mindfulness and self‐regulation on affective and cognitive outcomes within college students' natural environments. College students (n = 186) received six surveys per day for seven consecutive days in 2021, 2022, and 2023 using the Expiwell application. Each survey measured students' momentary affect, perceived cognition, mindfulness, and self‐regulation levels. Due to nested data structure, multilevel models were used for analysis. Findings from 4982 EMA surveys revealed that higher levels of momentary mindfulness and self‐regulation at one‐time point were positively associated with perceived cognition (β = 0.102, p

Abstract Covalent organic frameworks (COFs) face limited processability challenges as photoelectrodes in photoelectrochemical water reduction. Herein, sub‐10 nm benzothiazole‐based colloidal conjugated reticular oligomers (CROs) are synthesized using an aqueous nanoreactor approach, and the end‐capping molecular strategy to engineer electron‐deficient units onto the periphery of a CRO nanocrystalline lattices (named CROs‐Cg). This results in stable and processable “electronic inks” for flexible photoelectrodes. CRO‐BtzTp‐Cg and CRO‐TtzTp‐Cg expand the absorption spectrum into the infrared region and improve fluorescence lifetimes. Heterojunction device engineering is used to develop interlayer heterojunction and bulk heterojunction (BHJ) photoelectrodes with a hole transport layer, electron transport layer, and the main active layers, using a CROs/CROs‐Cg or one‐dimensional (1D) electron‐donating polymer HP18 mixed solution via spinning coating. The ITO/CuI/CRO‐TtzTp‐Cg‐HP18/SnO2/Pt photoelectrode shows a photocurrent of 94.9 µA cm‒2 at 0.4 V versus reversible hydrogen electrode (RHE), which is 47.5 times higher than that of ITO/Bulk‐TtzTp. Density functional theory calculations show reduced energy barriers for generating adsorbed H* intermediates and increased electron affinity in CROs‐Cg. Mott‐Schottky and charge density difference analyses indicate enhanced charge carrier densities and accelerated charge transfer kinetics in BHJ devices. This study lays the groundwork for large‐scale production of COF nanomembranes and heterojunction structures, offering the potential for cost‐effective, printable energy systems.

Abstract A20‐binding inhibitor of NF‐κB activation (ABIN1) is a polyubiquitin‐binding protein that regulates cell death and immune responses. Although Abin1 is located on chromosome 5q in the region commonly deleted in patients with 5q minus syndrome, the most distinct of the myelodysplastic syndromes (MDSs), the precise role of ABIN1 in MDSs remains unknown. In this study, mice with a mutation disrupting the polyubiquitin‐binding site (Abin1Q478H/Q478H) is generated. These mice develop MDS‐like diseases characterized by anemia, thrombocytopenia, and megakaryocyte dysplasia. Extramedullary hematopoiesis and bone marrow failure are also observed in Abin1Q478H/Q478H mice. Although Abin1Q478H/Q478H cells are sensitive to RIPK1 kinase–RIPK3–MLKL‐dependent necroptosis, only anemia and splenomegaly are alleviated by RIPK3 deficiency but not by MLKL deficiency or the RIPK1 kinase‐dead mutation. This indicates that the necroptosis‐independent function of RIPK3 is critical for anemia development in Abin1Q478H/Q478H mice. Notably, Abin1Q478H/Q478H mice exhibit higher levels of type I interferon (IFN‐I) expression in bone marrow cells compared towild‐type mice. Consistently, blocking type I IFN signaling through the co‐deletion of Ifnar1 greatly ameliorated anemia, thrombocytopenia, and splenomegaly in Abin1Q478H/Q478H mice. Together, these results demonstrates that ABIN1(Q478) prevents the development of hematopoietic deficiencies by regulating type I IFN expression.

Brazzein has excellent potential for use as a sweetener because of its high level of sweetening potency and stability against extreme temperature and pH. It is extracted from the tropical and difficult—to‐cultivate African plant Pentadiplandra brazzeana, which hampers its commercial viability. Here we report the mammary‐specific expression of wildtype or triple mutational (H31R/E36D/E41A) des‐pGlu brazzeins in the milk of transgenic mice. Using enzyme‐linked immunoassay (ELISA), western blot, and sweetness intensity testing, we confirmed that the triple mutation made the des‐pGlu brazzein molecule 10,000 times sweeter than sucrose in a weight base, even after 10 min of incubation at 100 °C; in addition, the triple mutant was also significantly sweeter than the wildtype des‐pGlu brazzein. This study provides new insights for producing brazzein or brazzein‐sweetened milk from animals for use in food and healthcare applications.

Abstract Objectives To reveal the relationship between the fibulin‐2 protein and immune dysfunction after bone trauma. Methods Individuals who were admitted to the study were divided into a bone trauma group, a recovered from bone trauma group and a volunteer without bone trauma group based on the reason for admission. Fibulin‐2 levels in the three groups were compared. Fibulin‐2‐knockout (fibulin‐2−/−) mice and wild‐type (WT) mice were used to detect susceptibility to infection. Hematoxylin and eosin (HE) staining and immunohistochemical staining were employed to observe pathological changes in each organ from fibulin‐2−/− mice and WT mice. Results In total, 132 patients were enrolled in this study. The fibulin‐2 level in the bone trauma group was lower than that in the recovered bone trauma group (3.39 ± 1.41 vs. 4.30 ± 1.38 ng/mL, t = 2.948, p

Abstract Adaptive beamformers at the element level usually require a great number of training samples and the computational cost for calculating the weight vector for large phased array antennas is very high, which make it difficult for real‐time applications. To address this problem, a two‐dimensional (2‐D) adaptive beamformer applicable to large planar array antennas that have low computational complexity and low training sample requirement is proposed. In the proposed method, the weight matrix is first reconstructed as a matrix that has the same or close columns and rows by utilising the special Kronecker property of the array steering matrix. Then, the weight vector is determined by adopting a bi‐quadratic cost function and a bi‐iterative algorithm. Experimental results show that the proposed method can achieve fairly good performance even when the training samples are small.

This paper demonstrates a detailed analysis of the feasibility for compact formation system around an L2-type artificial equilibrium point by means of continuous low-thrust propulsion in the hybrid form of solar sail and Coulomb force propulsion. Firstly, in view of non-ideal solar sail, the position of L2-type artificial equilibrium point and numerical periodic orbits around L2 utilized as leader’s nominal trajectory are given. Secondly, considering the external disturbances in the deep space environment, the nonlinear dynamic model of the spacecraft formation system based on the circular restricted three-body problem (CRTBP) is derived, under the assumption that the leader covers the nominal trajectory and each follower adjusts its propulsive acceleration vector (that is, both its sail attitude and electrostatic charge) in order to track a desired relative trajectory. Thirdly, based on a new double power combination function reaching law, a fast integral terminal sliding mode control methodology (MFITSM) is ameliorated to achieve orbital tracking rapidly, which has better robustness against external disturbances and the buffeting effect during spacecraft propulsion simultaneously. To properly allocate control inputs, a novel optimal allocation scheme is designed to calculate the charge product of the spacecrafts and sail attitude angles, which can make the magnitude of the acceleration required from the Coulomb propulsion system minimum and avoid formation geometry instabilities by balancing electrostatic interaction between adjacent spacecraft. Finally, several numerical examples are conducted to validate the superiority of the proposed control algorithm.

Abstract Neoadjuvant chemotherapy (NACT) remains an attractive alternative for controlling locally advanced cervical cancer. However, approximately 15–34% of women do not respond to induction therapy. To develop a risk stratification tool, 56 patients with stage IB‐IIB cervical cancer are included in 2 research centers from the discovery cohort. Patient‐specific somatic mutations led to NACT non‐responsiveness are identified by whole‐exome sequencing. Next, CRISPR/Cas9‐based library screenings are performed based on these genes to confirm their biological contribution to drug resistance. A 15‐gene classifier is developed by generalized linear regression analysis combined with the logistic regression model. In an independent validation cohort of 102 patients, the classifier showed good predictive ability with an area under the curve of 0.80 (95% confidence interval (CI), 0.69–0.91). Furthermore, the 15‐gene classifier is significantly associated with patient responsiveness to NACT in both univariate (odds ratio, 10.8; 95% CI, 3.55–32.86; p = 2.8 × 10−5) and multivariate analysis (odds ratio, 17.34; 95% CI, 4.04–74.40; p = 1.23 × 10−4) in the validation set. In conclusion, the 15‐gene classifier can accurately predict the clinical response to NACT before treatment, representing a promising approach for guiding the selection of appropriate treatment strategies for locally advanced cervical cancer.

Abstract Background Inflammatory osteolysis is a severe infectious bone disorder that occurs during orthopaedic surgery and is caused by disruptions in the dynamic balance of bone matrix homeostasis, which makes this condition a burden on surgical procedures. Developing novel therapeutic drugs about inhibiting excessive osteoclastogenesis acts as an efficient approach to preventing inflammatory bone destruction. Methods To study this, we explored the potential effects and mechanisms of compound 17 on inflammatory osteolysis in vitro. Meanwhile, a lipopolysaccharide (LPS)‐induced calvarial osteolysis mouse model was used to evaluate the protective effect of compound 17 on inflammatory bone destruction in vivo. Results In our study, we found that compound 17 could inhibit osteoclast (OC) differentiation and bone resorption during RANKL and LPS stimulation in a time‐ and dose‐dependent manner, while compounds 5 and 13 did not have the same effects. Mechanistically, compound 17 promoted phosphatase and tensin homologue (PTEN) activity by reducing PTEN ubiquitination, thereby restraining the RANKL‐induced NF‐κB pathway, resulting in the inhibition of the expression of osteoclastogenesis‐related genes and the formation of the NLRP3 inflammasome. Additionally, we also investigated whether compound 17 could negatively modulate macrophage polarization and repolarization due to its anti‐inflammatory effects. Moreover, compound 17 also plays an important role in osteoblast differentiation and mineralization. In vivo experiments showed that compound 17 could effectively protect mice from LPS‐induced inflammatory bone destruction by inhibiting osteoclastogenesis and inflammation. Conclusions Taken together, these results show that compound 17 might play protective role in inflammatory bone destruction through inhibiting osteoclastogenesis and inflammation. These findings imply a possible role of compound 17 in inflammatory osteolysis‐related diseases.

Abstract Ternary strategy is a promising approach to broaden the photoresponse of polymer solar cells (PSCs) by adopting combinatory photoactive blends. However, it could lead to a more complicated situation in manipulating the bulk morphology. Achieving an ideal morphology that enhances the charge transport and light absorption simultaneously is an essential avenue to promote the device performance. Herein, two polymers with different lengths of side groups (P1 is based on phenyl side group and P2 is based on biphenyl side group) are adopted in the dual‐acceptor ternary systems to evaluate the relationship between conjugated side group and crystalline behavior in the ternary system. The P1 ternary system delivers a greatly improved power conversion efficiency (PCE) of 13.06%, which could be attributed to the intense and broad photoresponse and improved charge transport originating from the improved crystallinity. Inversely, the P2 ternary device only exhibits a poor PCE of 8.97%, where the decreased device performance could mainly be ascribed to the disturbed molecular stacking of the components originating from the overlong conjugated side group. The results demonstrate a conjugated side group could greatly determine the device performance by tuning the crystallinity of components in ternary systems.

A novel bi-iterative dimension-reduced space–time adaptive processing (STAP) algorithm for clutter suppression and moving target detection in airborne radar system is proposed. A dimension-reduced processing in both space and time is firstly performed. Then a bi-quadratic cost function is constructed to estimate the dimension-reduced spatiotemporal filter coefficients, which are used for suppressing the clutter and keeping the target signal. An optimal solution to the cost function can be obtained efficiently by a bi-iteration algorithm. Theoretical analysis and computer simulation results illustrate that the algorithm has fast convergence, low computation load and sampling requirements. The results of experiment by using the measured data show the validity of the proposed algorithm.

The performance of the conventional adaptive beamformer undergoes degradation in the presence of the mutual coupling between the neighbouring elements. To eliminate the sensitivity for the MC, the dummy elements are fixed around the array. Here, the authors demonstrate the optimal layers of auxiliary elements for uniform rectangular array (URA) in the case of the specific MC model and give the concrete theoretical proof. The corresponding derivation proves that only one layer of auxiliary elements is needed to tackle with the MC effect, and the output SINR and beampattern are improved by means of the proposed method for URA. Finally, the simulation results have shown the effectiveness of authors’ method.

With the imaging advantage of bistatic forward-looking synthetic aperture radar, collaborative forward-looking imaging and reconnaissance technology for manned/unmanned aerial vehicles could be performed, in which unmanned aerial vehicle can realise two-dimensional (2-D) and high-resolution imaging and further attacking targets in its straight-ahead position. However, there exists more complicated space-variance property in this special configuration than traditional mono-static SAR. Such property will lead to performance deterioration of imaging if not corrected effectively. To address this problem, 2-D frequency spectrum with high precision is first obtained based on squint minimisation method here, and then a novel-phase space-variance correction method is developed through polynomial fitting. Imaging focus performance on targets could be improved significantly with authors’ method. Several simulations for scattering targets confirm its validity.

In order to improve the angle accuracy and meet the requirement of side-lobe blanking, the fire-control radar system usually adopts sum beam, azimuth difference beam, elevation difference beam and several protecting antennas simultaneously. A ΣΔG-STAP method based on sum, difference and protecting channels is proposed to improve the performance of ground moving target detection. Moreover, the target is located on the Doppler beam sharpening image by the monopulse angle estimation technique. The effectiveness of the proposed method is verified using the simulated data and measured data.

Anisotropic picosecond photovoltaic responses were observed in lanthanum doped manganite LaxCa1-xMnO3 (x=0.67 and 0.4) thin films, which were deposited on miscut LaSrAlO4 substrates under ultraviolet pulsed laser irradiation without external bias. The 10%–90% rise time and the full width at half maximum of La0.67Ca0.33MnO3 were 470 and 585 ps, respectively, and those of La0.4Ca0.6MnO3 were 220 and 515 ps. The photovoltage sensitivities of La0.67Ca0.33MnO3 and La0.4Ca0.6MnO3, which are sensitive to the concentrations of lanthanum of the samples, are 0.28 V/mJ and 3.47 V/mJ, respectively. The photosensitivity in the films deposited on MgO is higher than that in those deposited on LaSrAlO4 substrates, for it has a big lattice mismatch. These results should open a route for the application of lanthanum doped manganite as an ultrafast photodetector material.

Abstract Distinguishing the independent contributions of tectonic denudation and climate‐driven erosion on the production and supply of clastic materials of Chinese eolian deposits is important in understanding the dynamic links between global climate changes, tectonics, and Asian dust emission. Here, multi‐proxy rock magnetic records of detrital fractions of Chinese eolian deposits since ∼6 Ma, combined with further comparison with dust accumulation rates and geochemical data, suggest that limited production and supply of clastic materials of Chinese eolian deposits were observed between 5.6 and 4.4 Ma in a warmer climate, and thereafter an increasing trend is evident during a cooler world. We propose that intense physical erosion under cooler conditions caused increasing production of fresh detrital components, exerting dominant influences on the sediment supply to Asian eolian deposits. This study provides direct evidence of dynamic coupling between intensified physical erosion and Asian dust activity under late Cenozoic global cooling.

Abstract The acquisition cycle of remote sensing images is slow, and the labelling process encounters challenges, which have become prominent with the rapid development of remote sensing image object detection research. Therefore, this article provides a way to make the model better capture the diversity and contextual relationships in the data, and solve this problem by more than just data augmentation. Specifically, this method is a few‐shot object detection method for remote sensing based on global context combined with implicit knowledge decoupled head (GC‐IKDH). This method first uses a segmentation strategy to convert high‐resolution images into low‐resolution images and expands the sample size through a generative model. Secondly, GC attention is introduced to generate a GC vector by weighting and averaging the information of each position in the input sequence, which helps the model better understand the semantics of the input sequence. Finally, an IKDH is added to improve the model head, which is used to learn specific features in the data so that the model can better handle the diversity in the data. Experimental results show that GC attention and IKDH boosting provide a good performance boost to the baseline model. Compared with other few‐shot samples, this method achieves state‐of‐the‐art performance under different shot settings and highly competitive results on two benchmark datasets (NWPU VHR‐10 and DIOR).

Abstract Mineral dust plays an important role in Earth's climate system, yet it is difficult to identify dust imprints in paleofluvial sediments, especially on orbital timescales. Here, we present high‐resolution authigenic carbonate Ca–Mg–Sr compositions in a fluvial sequence under the transport pathway of Asian dust. The Mg/Ca, Sr/Ca, and Mg/Sr ratios exhibit distinct transitions in both secular trends and orbital cycles at ∼8 Ma. Before ∼8 Ma, given similar Mg and Sr partitioning behaviors during carbonate formation, hydroclimate changes yielded strong orbital signals in the Sr/Ca and Mg/Ca ratios but no detectable signals in the Mg/Sr ratios. After ∼8 Ma, given the strengthened input of Mg‐rich dust during cold‒dry periods, the Mg/Sr and Mg/Ca ratios clearly exhibited orbital signals, but the Sr/Ca ratio did not. Such transitions in carbonate composition corroborate the dust‐induced changes in fluvial hydrochemistry, offering an innovative methodology for detecting orbital dust cycles in paleofluvial systems.

Abstract Hydrogen‐bonded organic frameworks (HOFs) are emerging porous materials that show high structural flexibility, mild synthetic conditions, good solution processability, easy healing and regeneration, and good recyclability. Although these properties give them many potential multifunctional applications, their frameworks are unstable due to the presence of only weak and reversible hydrogen bonds. In this work, the development history and synthesis methods of HOFs are reviewed, and categorize their structural design concepts and strategies to improve their stability. More importantly, due to the significant potential of the latest HOF‐related research for addressing energy and environmental issues, this work discusses the latest advances in the methods of energy storage and conversion, energy substance generation and isolation, environmental detection and isolation, degradation and transformation, and biological applications. Furthermore, a discussion of the coupling orientation of HOF in the cross‐cutting fields of energy and environment is presented for the first time. Finally, current challenges, opportunities, and strategies for the development of HOFs to advance their energy and environmental applications are discussed.