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Your search keyword '"YILDIZ, MEHMET"' showing total 42 results
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42 results on '"YILDIZ, MEHMET"'

4. Assessment of the transition of care from pediatric to adult rheumatology in a tertiary center

Author

Yıldız, Amra Adrovic, Ugurlu, Serdal; Ayla, Ali Yagiz; Besiroglu, Helin Idil; Azman, Feyza Nur; Egeli, Bugra; Eren, Hatice; Durucan, Ibrahim; Alkan, Arif; Ozturk, Sila; Ergun, Sercan; Barut, Kenan; Haslak, Fatih; Sahin, Sezgin; Yildiz, Mehmet; Ozdogan, Huri; Kasapcopur, Ozgur, Koç University Hospital, Yıldız, Amra Adrovic, Ugurlu, Serdal; Ayla, Ali Yagiz; Besiroglu, Helin Idil; Azman, Feyza Nur; Egeli, Bugra; Eren, Hatice; Durucan, Ibrahim; Alkan, Arif; Ozturk, Sila; Ergun, Sercan; Barut, Kenan; Haslak, Fatih; Sahin, Sezgin; Yildiz, Mehmet; Ozdogan, Huri; Kasapcopur, Ozgur, and Koç University Hospital

Abstract

NA

Published
2023

7. Data‐Driven Magnetic Resonance Imaging Definitions for Active and Structural Sacroiliac Joint Lesions in Juvenile Spondyloarthritis Typical of Axial Disease: A Cross‐Sectional International Study

Author

Weiss, Pamela F., primary, Brandon, Timothy G., additional, Lambert, Robert G., additional, Biko, David M., additional, Chauvin, Nancy A., additional, Francavilla, Michael L., additional, Jaremko, Jacob L., additional, Herregods, Nele, additional, Kasapcopur, Ozgur, additional, Yildiz, Mehmet, additional, Hendry, Alison M., additional, and Maksymowych, Walter P., additional

Published
2023
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8. Frequency and outcomes of STEMI patients presenting between 12 and 24 h after symptom onset: Late‐presenting STEMI

Author

Griffin, Anna C. Gonzalez, primary, Yildiz, Mehmet, additional, Bradley, Steven, additional, Smith, Jenna E., additional, Garcia, Santiago, additional, Schmidt, Christian W., additional, Garberich, Ross, additional, Walser‐Kuntz, Evan, additional, Traverse, Jay, additional, Jollis, James G., additional, Sharkey, Scott W., additional, and Henry, Timothy D., additional

Published
2022
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34. Serum Cytokine Levels in Behçet's Disease

Author

Akkurt, Zeynep Meltem, primary, Bozkurt, Mehtap, additional, Uçmak, Derya, additional, Yüksel, Hatice, additional, Uçak, Haydar, additional, Sula, Bilal, additional, Gürsel Özkurt, Zeynep, additional, Yildiz, Mehmet, additional, Akdeniz, Dicle, additional, and Arica, Mustafa, additional

Published
2014
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40. Classification Criteria for Axial Disease in Youth With Juvenile Spondyloarthritis.

Author

Weiss PF, Brandon TG, Aggarwal A, Burgos-Vargas R, Colbert RA, Horneff G, Laxer RM, Minden K, Ravelli A, Ruperto N, Smith JA, Stoll ML, Tse SM, Van den Bosch F, Maksymowych WP, Lambert RG, Biko DM, Chauvin NA, Francavilla ML, Jaremko JL, Herregods N, Kasapcopur O, Yildiz M, Srinivasalu H, Lovell DJ, Nigrovic PA, Foeldvari I, Klein-Gitelman MS, Ozen S, Naden R, Hendry AM, and Joos R

Subjects
Humans, Adolescent, Male, Female, Sacroiliitis diagnostic imaging, Child, Arthritis, Juvenile classification, Arthritis, Juvenile complications, Spondylarthritis classification, Spondylarthritis complications, Axial Spondyloarthritis
Abstract

Objective: The goal was to develop and validate classification criteria for axial juvenile spondyloarthritis (SpA; AxJSpA)., Methods: This international initiative consisted of four phases: (1) item generation, (2) item reduction, (3) criteria development, and (4) validation of the AxJSpA criteria by an independent team of experts in an internationally representative validation cohort., Results: These criteria are intended to be used on youth with a physician diagnosis of juvenile SpA and for whom axial disease is suspected. Item generation consisted of a systematic literature review and a free-listing exercise using input from international physicians, which collectively resulted in 108 items. After the item reduction exercise and expert panel input, 37 items remained for further consideration. The final AxJSpA criteria domains included the following: imaging of active inflammation, imaging of structural lesions, pain chronicity, pain pattern, pain location, stiffness, and genetics. The most heavily weighted domains were active inflammation and structural lesions on imaging. Imaging typical of sacroiliitis was deemed necessary, but not sufficient, to classify a youth with AxJSpA. The threshold for classification of AxJSpA was a score of ≥55 (out of 100). When tested in the validation data set, the final criteria had a specificity of 97.5% (95% confidence interval [CI] 91.4%-99.7%), sensitivity of 64.3% (95% CI 54.9%-73.1%), and area under the receiver operating characteristic curve of 0.81 (95% CI 0.76%-0.86%)., Conclusion: The new AxJSpA classification criteria require an entry criterion and a physician diagnosis of juvenile SpA and include seven weighted domains. The AxJSpA classification criteria are validated and designed to identify participants for research studies., (© 2024 American College of Rheumatology.)

Published
2024
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41. Achieving the balance: Biphasic effects of genistein on PC-3 cells.

Author

Terzioglu-Usak S, Yildiz MT, Goncu B, and Ozten-Kandas N

Subjects
Apoptosis drug effects, Cell Proliferation drug effects, Cell Survival drug effects, DNA Damage drug effects, Genistein chemistry, Humans, Male, PC-3 Cells, Prostatic Neoplasms genetics, Prostatic Neoplasms metabolism, Prostatic Neoplasms physiopathology, Smad Proteins genetics, Smad Proteins metabolism, Transforming Growth Factor beta genetics, Transforming Growth Factor beta metabolism, Genistein pharmacology, Prostatic Neoplasms drug therapy
Abstract

This study examined the response of PC-3 cells to physiological (0.5, 2.5, 5, 10 μM) and pharmacological (50 μM) concentrations of genistein which is a main bioactive compound in soy. Following 48 hr genistein treatment, cell-based assays and genome-wide microarray were performed. It was evidenced that maximal physiologically achievable concentrations of genistein (0.5-10 μM) lead to significant increase in cell viability (p < 0.05) and decrease in migration at 0.5 μM (p = 0.000) and 10 μM (p = 0.001). The highest percentage of apoptotic cells was obtained at 50 μM. Microarray analysis gave the most critical pathways such as cell cycle regulation and proliferation, tumorigenesis, DNA damage and repair, stress response, and apoptosis. Physiological concentrations (≤10 μM) induced activation of CDKs, MAPKs, and RPSKs, while high concentrations of genistein (>10 μM) appeared to have a novel mechanism of action, specifically down-regulating TGF-β by decreasing specifically SMAD 2/3,4 which are in the downstream TGF-β signaling cascade. PRACTICAL APPLICATIONS: This study highlights for the first time that maximal physiologically achievable concentrations of genistein (0.5-10 μM) have proliferative effects evidenced by alterations in global gene expression patterns of PC-3 cells. Our results particularly represent a closer examination of dietary genistein consumption for the prevention and/or treatment of cancer that maximal physiologically achievable concentrations of genistein could have detrimental effects on individuals with prostate cancer. Further studies as in vivo would be necessary to remove shadows on the effect of genistein on prostate cancer progression., (© 2019 Wiley Periodicals, Inc.)

Published
2019
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42. Serum Cytokine Levels in Behçet's Disease.

Author

Akkurt ZM, Bozkurt M, Uçmak D, Yüksel H, Uçak H, Sula B, Gürsel Özkurt Z, Yildiz M, Akdeniz D, and Arica M

Subjects
Adult, Female, Humans, Male, Behcet Syndrome blood, Cytokines blood
Abstract

Background: The aim of this study is to investigate and compare the serum levels of various cytokines in patients with Behçet's Disease and healthy controls., Methods: Thirty-five patients with Behçet's disease and 29 age and sex-matched healthy controls were included in the study. The patients were separated into groups with active and inactive disease. Serum IL-2, IL-6, IL-8, IL-10, IL-17A, and IFN-γ levels were determined using the enzyme-linked immunosorbent assay method. Cytokine levels of the two patient groups and healthy controls were compared using SPSS 15.0., Results: Ten patients with active disease and 25 patients with inactive disease were present. Serum IL-8 levels of active BD patients were higher compared to inactive patients (P = 0.048) and healthy controls (P = 0.02). IL-8 levels were correlated with the duration of symptoms (r = 0.490, P = 0.003) and time passed since diagnosis (r = 0.579, P ˂ 0.001)., Conclusion: Behçet's disease involves complex interactions of cells of the immune system, mainly T lymphocytes and neutrophils. Further studies on the cytokine profile in Behçet's disease will aid in elucidation of its pathogenesis., (© 2014 Wiley Periodicals, Inc.)

Published
2015
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