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Your search keyword '"Yang, Huilan"' showing total 8 results
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8 results on '"Yang, Huilan"'

1. Clinical guideline for the diagnosis and treatment of cutaneous warts (2022)

Author

Zhu, Peiyao, primary, Qi, Rui‐Qun, additional, Yang, Yang, additional, Huo, Wei, additional, Zhang, Yuqing, additional, He, Li, additional, Wang, Gang, additional, Xu, Jinhua, additional, Zhang, Furen, additional, Yang, Rongya, additional, Tu, Ping, additional, Ma, Lin, additional, Liu, Quanzhong, additional, Li, Yuzhen, additional, Gu, Heng, additional, Cheng, Bo, additional, Chen, Xiang, additional, Chen, Aijun, additional, Xiao, Shengxiang, additional, Jin, Hongzhong, additional, Zhang, Junling, additional, Li, Shanshan, additional, Yao, Zhirong, additional, Pan, Weihua, additional, Yang, Huilan, additional, Shen, Zhu, additional, Cheng, Hao, additional, Song, Ping, additional, Fu, Lingyu, additional, Chen, Hongxiang, additional, Geng, Songmei, additional, Zeng, Kang, additional, Wang, Jianjian, additional, Tao, Juan, additional, Chen, Yaolong, additional, Wang, Xiuli, additional, and Gao, Xing‐Hua, additional

Published
2022
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5. Combination of 308-nm Excimer Laser With Topical Pimecrolimus For the Treatment of Childhood Vitiligo

Author

Yang HuiLan, Huang Xiao-Yan, Fan JianYong, and Liu Zong-Rong

Subjects
Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Vitiligo, Skin Pigmentation, Dermatology, Administration, Cutaneous, Tacrolimus, Group B, law.invention, Pimecrolimus, Randomized controlled trial, law, 308 nm excimer laser, Humans, Medicine, Combined Modality Therapy, Single-Blind Method, Low-Level Light Therapy, Child, Excimer laser, business.industry, Significant difference, medicine.disease, Pediatrics, Perinatology and Child Health, Female, Lasers, Excimer, Dermatologic Agents, business, medicine.drug
Abstract

Forty-nine patients enrolled in a single-blinded, randomized, comparing 308-nm excimer laser therapy together with topical 1% pimecrolimus cream twice daily (group A) with excimer laser therapy twice per week (group B). Of 48 patients evaluated after 30 weeks of treatment, 71% of patients from group A achieved Grade 3 or 4 repigmentation compared with 50% in group B. Significant difference was found between group A and B at the end of 30 weeks of treatment (p = 0.001).

Published
2009

8. Stepwise identification of HLA-A*0201-restricted CD8+ T-cell epitope peptides from herpes simplex virus type 1 genome boosted by a StepRank scheme.

Author

Bi J, Song R, Yang H, Li B, Fan J, Liu Z, and Long C

Subjects
Epitopes, T-Lymphocyte genetics, Genome, Viral genetics, Genome-Wide Association Study, HLA-A Antigens genetics, HLA-A2 Antigen, Herpesvirus 1, Human genetics, Humans, Peptides genetics, Peptides immunology, Viral Envelope Proteins genetics, Viral Envelope Proteins immunology, Viral Proteins genetics, Viral Proteins immunology, CD8-Positive T-Lymphocytes immunology, Epitopes, T-Lymphocyte immunology, Genome, Viral immunology, HLA-A Antigens immunology, Herpesvirus 1, Human immunology
Abstract

Identification of immunodominant epitopes is the first step in the rational design of peptide vaccines aimed at T-cell immunity. To date, however, it is yet a great challenge for accurately predicting the potent epitope peptides from a pool of large-scale candidates with an efficient manner. In this study, a method that we named StepRank has been developed for the reliable and rapid prediction of binding capabilities/affinities between proteins and genome-wide peptides. In this procedure, instead of single strategy used in most traditional epitope identification algorithms, four steps with different purposes and thus different computational demands are employed in turn to screen the large-scale peptide candidates that are normally generated from, for example, pathogenic genome. The steps 1 and 2 aim at qualitative exclusion of typical nonbinders by using empirical rule and linear statistical approach, while the steps 3 and 4 focus on quantitative examination and prediction of the interaction energy profile and binding affinity of peptide to target protein via quantitative structure-activity relationship (QSAR) and structure-based free energy analysis. We exemplify this method through its application to binding predictions of the peptide segments derived from the 76 known open-reading frames (ORFs) of herpes simplex virus type 1 (HSV-1) genome with or without affinity to human major histocompatibility complex class I (MHC I) molecule HLA-A*0201, and find that the predictive results are well compatible with the classical anchor residue theory and perfectly match for the extended motif pattern of MHC I-binding peptides. The putative epitopes are further confirmed by comparisons with 11 experimentally measured HLA-A*0201-restrcited peptides from the HSV-1 glycoproteins D and K. We expect that this well-designed scheme can be applied in the computational screening of other viral genomes as well.

Published
2011
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