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1. New Compounds from the Roots and Stems ofTrigonostemon liiand Their Cytotoxic Activities

Author

Yong-Qin Liu, Xiao-Jiang Hao, Xu-Jia Hu, Yue-Hu Wang, and Ying-Tong Di

Subjects
010405 organic chemistry, Stereochemistry, Chemistry, Alkaloid, Organic Chemistry, 01 natural sciences, Biochemistry, Catalysis, Terpenoid, 0104 chemical sciences, Inorganic Chemistry, 010404 medicinal & biomolecular chemistry, Drug Discovery, Ic50 values, Cytotoxic T cell, Physical and Theoretical Chemistry
Abstract

A new carboline alkaloid, Trifiline D (1) and a new degraded diterpenoid, Trigoxyphin X (4) were isolated from the roots and stems of Trigonostemonlii. Their structures were elucidated by extensive spectroscopic analyses including 1D- and 2D-NMR techniques. Compound 1 exhibited weak inhibitory activity against MCF-7, A-549, MGC-803, and COLO-205 with IC50 values ranging from 27.4 to 35.4 mu M.

Published
2016
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