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5 results on '"Yoshitaka Ando"'

1. Association Between Circulating Ketone Bodies and Worse Outcomes in Hemodialysis Patients

Author

Masaru Obokata, Kazuaki Negishi, Hiroaki Sunaga, Hideki Ishida, Kyoko Ito, Tetsuya Ogawa, Tatsuya Iso, Yoshitaka Ando, and Masahiko Kurabayashi

Subjects
hemodialysis, ketone body, metabolism, prognostic factor, β‐hydroxybutyrate, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundCardiovascular disease is the leading cause of morbidity and mortality in patients receiving hemodialysis. Systemic metabolic perturbation is one of the hallmark abnormalities in patients at high cardiovascular risk. We sought to determine the relationship between circulating ketone body and clinical outcomes in patients with prevalent hemodialysis. Methods and ResultsWe retrospectively assessed the relationship between serum β‐hydroxybutyrate (βOHB), the most abundant ketone body in the circulation, and prognosis in 405 stable hemodialysis patients. During a mean follow‐up of 3.2±0.9 years, there were 54 major adverse cardiovascular events (defined as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization attributed to heart failure) and 67 all‐cause deaths. Major adverse cardiovascular events rates increased from 11.1 per 1000 person‐years in the lowest βOHB quintile (409 μmol/L). After adjusting for demographic characteristics, coronary artery disease, and atrial fibrillation, the highest βOHB quintile was associated with increased risk of major adverse cardiovascular events compared with the lowest quintile (hazard ratio, 10.2; 95% confidence interval [3.35–44.0]; P

Published
2017
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2. Maternal fructose–induced oxidative stress occurs via Tfam and Ucp5 epigenetic regulation in offspring hippocampi

Author

Hiroya Yamada, Kazuya Shiogama, Hiroaki Ishikawa, Shuji Hashimoto, Yohei Shimono, Genki Mizuno, Ryosuke Fujii, Yoshitaka Ando, Nao Sadamoto, Koji Suzuki, Eiji Munetsuna, Mirai Yamazaki, and Koji Ohashi

Subjects
0301 basic medicine, medicine.medical_specialty, Offspring, Fructose intake, Fructose, TFAM, Biology, medicine.disease_cause, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Endocrinology, chemistry, Internal medicine, DNA methylation, Genetics, medicine, High fructose, Epigenetics, Molecular Biology, 030217 neurology & neurosurgery, Oxidative stress, Biotechnology
Abstract

Fructose consumption is rising globally, but maternal high fructose intake might adversely affect offspring. Our previous report demonstrated that excess maternal fructose intake impairs hippocampa...

Published
2019

3. Simple evaluation of aortic arch calcification by chest radiography in hemodialysis patients

Author

Nami Matsuda, Kyoko Ito, Akiko Matsuda, Hideki Ishida, Yoshitaka Ando, Tetsuya Ogawa, Kosaku Nitta, and Ayuko Fujiu

Subjects
Adult, Male, Aortic arch, medicine.medical_specialty, Radiography, medicine.medical_treatment, Aortic Diseases, Aorta, Thoracic, Renal Dialysis, medicine.artery, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, Aorta, business.industry, Calcinosis, Retrospective cohort study, Hematology, Middle Aged, medicine.disease, Pulse pressure, Nephrology, Kidney Failure, Chronic, Female, Aortic arch calcification, Hemodialysis, Radiology, Tomography, X-Ray Computed, business, Calcification
Abstract

Vascular calcification is associated with a poor prognosis in dialysis patients. It can be assessed with computed tomography but simple inoffice techniques may provide useful information. We compared the results obtained with a simple noninvasive technique with those obtained using multidetector computed tomography for aortic arch calcification volume (AoACV) in chronic hemodialysis (HD) patients. The enrolled study subjects were 63 (32 men and 31 women) maintenance HD patients. Calcification of the aortic arch was semiquantitatively estimated with a AoAC score (AoACS) on plain chest radiology. The AoACV was increased, with a mean value of 6.6 ranging from 0% to 36.5%. The coefficient of intraobserver variation was less than 2.5%. Aortic arch calcification score was highly correlated with AoACV (r=0.635, P

Published
2009

4. Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array

Author

Natalia Lapteva, Yoshitaka Ando, Mie Nieda, Katsushi Tokunaga, Akiko Kikuchi, Yoshihide Ishikawa, Takeo Juji, Hirohiko Hohjoh, Miki Okai, and Grigory Dymshits

Subjects
Gene expression profiling, medicine.anatomical_structure, Growth factor receptor, Monocyte, Cellular differentiation, CD14, Gene expression, medicine, Hematology, Cell cycle, Biology, Molecular biology, Transcription factor
Abstract

Using a human cDNA expression array, we obtained expression profiles of 588 genes in CD14+ monocytes and monocyte-derived dendritic cells (DCs). Overall, 22 genes were upregulated, and nine genes were downregulated in DCs of both samples from two different individuals. Many of the genes that were upregulated in DCs encode proteins that are related to differentiation, cell structure, migration, termination of cell cycle as well as proliferation, e.g. tumour necrosis factor-α (TNF-α), tumour necrosis factor receptor II (TNFRII), thymosin β-10, epithelial discoidin domain receptor 1, replication factor C, putative transcription factor DB1, alpha catenin, transforming growth factor-β1, prohibitin, p53-regulating protein and neu differentiation factor. Among the downregulated genes in DCs were genes that encode proteins of cell cycle regulation: mitotic growth and transcription activator, platelet-derived growth factor receptor-β subunit, interleukin 2 receptor (IL-2R)-γ subunit, IL-7R-α subunit, leucocyte interferon-γ (IFN-γ) and granulocyte–macrophage colony-stimulating factor receptor (GM-CSFR). Semi-quantitative reverse transcription–polymerase chain reaction method confirmed the upregulated expression levels in DCs for TNFRII, TNF-α, alpha catenin and downregulation of IFN-γ, GM-CSFR on four different donor samples of DCs and monocytes. Moreover, our data show the presence of a ‘switch-on’ step for the TNF-α and TNFRII gene expression in immature DCs for further differentiation into mature DCs.

Published
2001

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