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Your search keyword '"Yousefzadeh, Matthew J"' showing total 8 results
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8 results on '"Yousefzadeh, Matthew J"'

1. Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy

Author

Henpita, Chathurika, primary, Vyas, Rajesh, additional, Healy, Chastity L., additional, Kieu, Tra L., additional, Gurkar, Aditi U., additional, Yousefzadeh, Matthew J., additional, Cui, Yuxiang, additional, Lu, Aiping, additional, Angelini, Luise A., additional, O'Kelly, Ryan D., additional, McGowan, Sara J., additional, Chandrasekhar, Sanjay, additional, Vanderpool, Rebecca R., additional, Hennessy‐Wack, Danielle, additional, Ross, Mark A., additional, Bachman, Timothy N., additional, McTiernan, Charles, additional, Pillai, Smitha P. S., additional, Ladiges, Warren, additional, Lavasani, Mitra, additional, Huard, Johnny, additional, Beer‐Stolz, Donna, additional, St. Croix, Claudette M., additional, Watkins, Simon C., additional, Robbins, Paul D., additional, Mora, Ana L., additional, Kelley, Eric E., additional, Wang, Yinsheng, additional, O'Connell, Timothy D., additional, and Niedernhofer, Laura J., additional

Published
2023
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2. Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Author

Zhang, Lei, primary, Zhao, Jing, additional, Mu, Xiaodong, additional, McGowan, Sara J., additional, Angelini, Luise, additional, O'Kelly, Ryan D., additional, Yousefzadeh, Matthew J., additional, Sakamoto, Ayumi, additional, Aversa, Zaira, additional, LeBrasseur, Nathan K., additional, Suh, Yousin, additional, Huard, Johnny, additional, Kamenecka, Theodore M., additional, Niedernhofer, Laura J., additional, and Robbins, Paul D., additional

Published
2021
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3. Exercise reduces circulating biomarkers of cellular senescence in humans

Author

Englund, Davis A., primary, Sakamoto, Ayumi E., additional, Fritsche, Chad M., additional, Heeren, Amanda A., additional, Zhang, Xu, additional, Kotajarvi, Brian R., additional, Lecy, Denise R., additional, Yousefzadeh, Matthew J., additional, Schafer, Marissa J., additional, White, Thomas A., additional, Atkinson, Elizabeth J., additional, and LeBrasseur, Nathan K., additional

Published
2021
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5. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Author

Yousefzadeh, Matthew J., primary, Zhao, Jing, additional, Bukata, Christina, additional, Wade, Erin A., additional, McGowan, Sara J., additional, Angelini, Luise A., additional, Bank, Michael P., additional, Gurkar, Aditi U., additional, McGuckian, Collin A., additional, Calubag, Mariah F., additional, Kato, Jonathan I., additional, Burd, Christin E., additional, Robbins, Paul D., additional, and Niedernhofer, Laura J., additional

Published
2020
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6. Adenoviral gene transfer of a single‐chain IL‐23 induces psoriatic arthritis–like symptoms in NOD mice

Author

Flores, Rafael R., primary, Carbo, Lana, additional, Kim, Eun, additional, Van Meter, Montina, additional, De Padilla, Consuelo M. Lopez, additional, Zhao, Jing, additional, Colangelo, Debora, additional, Yousefzadeh, Matthew J., additional, Angelini, Luise A., additional, Zhang, Lei, additional, Pola, Enrico, additional, Vo, Nam, additional, Evans, Christopher H., additional, Gambotto, Andrea, additional, Niedernhofer, Laura J., additional, and Robbins, Paul D., additional

Published
2019
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7. Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans

Author

Yousefzadeh, Matthew J., primary, Schafer, Marissa J., additional, Noren Hooten, Nicole, additional, Atkinson, Elizabeth J., additional, Evans, Michele K., additional, Baker, Darren J., additional, Quarles, Ellen K., additional, Robbins, Paul D., additional, Ladiges, Warren C., additional, LeBrasseur, Nathan K., additional, and Niedernhofer, Laura J., additional

Published
2017
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8. Adenoviral gene transfer of a single‐chain IL‐23 induces psoriatic arthritis–like symptoms in NOD mice

Author

Christopher H. Evans, Jing Zhao, Consuelo M. Lopez De Padilla, Matthew J. Yousefzadeh, Montina Van Meter, Nam Vo, Lei Zhang, Lana Carbo, Andrea Gambotto, Enrico Pola, Luise A. Angelini, Laura J. Niedernhofer, Eun Kim, Debora Colangelo, Paul D. Robbins, Rafael Flores, Flores, Rafael R, Carbo, Lana, Kim, Eun, Van Meter, Montina, De Padilla, Consuelo M Lopez, Zhao, Jing, Colangelo, Debora, Yousefzadeh, Matthew J, Angelini, Luise A, Zhang, Lei, Pola, Enrico, Vo, Nam, Evans, Christopher H, Gambotto, Andrea, Niedernhofer, Laura J, and Robbins, Paul D

Subjects
0301 basic medicine, Erythema, adenoviru, type 1 diabetes, Enzyme-Linked Immunosorbent Assay, adenovirus, interleukin-17, interleukin-23, psoriasis, Biochemistry, Adenoviridae, Viral vector, Mice, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Settore MED/04 - PATOLOGIA GENERALE, Mice, Inbred NOD, Psoriasis, Genetics, medicine, Interleukin 23, Animals, Molecular Biology, Skin, psoriasi, NOD mice, Inflammation, biology, business.industry, Research, Arthritis, Psoriatic, Flow Cytometry, medicine.disease, Immunohistochemistry, 030104 developmental biology, Immunology, biology.protein, Female, Lymph Nodes, Interleukin 17, medicine.symptom, Antibody, business, 030217 neurology & neurosurgery, Biotechnology
Abstract

Previously, we demonstrated that intratumoral delivery of adenoviral vector encoding single-chain (sc)IL-23 (Ad.scIL-23) was able to induce systemic antitumor immunity. Here, we examined the role of IL-23 in diabetes in nonobese diabetic mice. Intravenous delivery of Ad.scIL-23 did not accelerate the onset of hyperglycemia but instead resulted in the development of psoriatic arthritis. Ad.scIL-23-treated mice developed erythema, scales, and thickening of the skin, as well as intervertebral disc degeneration and extensive synovial hypertrophy and loss of articular cartilage in the knees. Immunological analysis revealed activation of conventional T helper type 17 cells and IL-17-producing gamma delta T cells along with a significant depletion and suppression of T cells in the pancreatic lymph nodes. Furthermore, treatment with anti-IL-17 antibody reduced joint and skin psoriatic arthritis pathologies. Thus, these Ad.scIL-23-treated mice represent a physiologically relevant model of psoriatic arthritis for understanding disease progression and for testing therapeutic approaches.-Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J., Robbins, P. D. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.

Published
2019
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