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Your search keyword '"Yu, Xiaowen"' showing total 27 results
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27 results on '"Yu, Xiaowen"'

2. Featured Cover

Author

Ye, Guanchen, primary, Yu, Xiaowen, additional, Wang, Baixiang, additional, Zhou, Yu, additional, Yu, Mengfei, additional, and Wang, Huiming, additional

Published
2023
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4. Anther‐specific expression of OsRIP1 causes dominant male sterility in rice

Author

Lei, Dekun, primary, Jian, Anqi, additional, Huang, Xianbo, additional, Liu, Xi, additional, Chen, Liangming, additional, Bai, Wenting, additional, Cheng, Siqi, additional, He, Xiaodong, additional, Xiong, Yehui, additional, Yu, Xiaowen, additional, Wang, Chaolong, additional, Zheng, Hai, additional, You, Shimin, additional, Wang, Qiming, additional, Lu, Jiayu, additional, Hu, Yang, additional, Xie, Zhenwei, additional, Jiang, Ling, additional, Zhang, Xin, additional, Ren, Yulong, additional, Lei, Cailin, additional, Cheng, Zhijun, additional, Lin, Qibing, additional, Wu, Chuanyin, additional, Zhu, Shanshan, additional, Zhao, Zhigang, additional, and Wan, Jianmin, additional

Published
2023
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7. Superscalar Phase Boundaries Derived Multiple Active Sites in SnO 2 /Cu 6 Sn 5 /CuO for Tandem Electroreduction of CO 2 to Formic Acid (Adv. Energy Mater. 13/2023)

Author

Shi, Yujie, primary, Wang, Yijie, additional, Yu, Jiayuan, additional, Chen, Yuke, additional, Fang, Chaoqiong, additional, Jiang, Di, additional, Zhang, Qinghua, additional, Gu, Lin, additional, Yu, Xiaowen, additional, Li, Xiao, additional, Liu, Hong, additional, and Zhou, Weijia, additional

Published
2023
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11. Front cover

Author

Zhao, Wenquan, primary, Ye, Guanchen, additional, Li, Qi, additional, Zhou, Yu, additional, Yu, Xiaowen, additional, Li, Yining, additional, Yu, Mengfei, additional, and Wang, Huiming, additional

Published
2022
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13. Hydrogen Evolution Linked to Selective Oxidation of Glycerol over CoMoO4-A Theoretically Predicted Catalyst

Author

Yu, Xiaowen, Araujo, Rafael B., Qiu, Zhen, dos Santos, Egon Campos, Anil, Athira, Cornell, Ann, Pettersson, Lars G. M., Johnsson, Mats, Yu, Xiaowen, Araujo, Rafael B., Qiu, Zhen, dos Santos, Egon Campos, Anil, Athira, Cornell, Ann, Pettersson, Lars G. M., and Johnsson, Mats

Abstract

Electrochemical valorization of biomass waste (e.g., glycerol) for production of value-added products (such as formic acid) in parallel with hydrogen production holds great potential for developing renewable and clean energy sources. Here, a synergistic effort between theoretical calculations at the atomic level and experiments to predict and validate a promising oxide catalyst for the glycerol oxidation reaction (GOR) are reported, providing a good example of designing novel, cost-effective, and highly efficient electrocatalysts for producing value-added products at the anode and high-purity hydrogen at the cathode. The predicted CoMoO4 catalyst is experimentally validated as a suitable catalyst for GOR and found to perform best among the investigated metal (Mn, Co, Ni) molybdate counterparts. The potential required to reach 10 mA cm(-2) is 1.105 V at 60 degrees C in an electrolyte of 1.0 m KOH with 0.1 m glycerol, which is 314 mV lower than for oxygen evolution. The GOR reaction pathway and mechanism based on this CoMoO4 catalyst are revealed by high-performance liquid chromatography and in situ Raman analysis. The coupled quantitative analysis indicates that the CoMoO4 catalyst is highly active toward C-C cleavage, thus presenting a high selectivity (92%) and Faradaic efficiency (90%) for formate production.

Published
2022
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18. Synergistic combination of DT‐13 and Topotecan inhibits aerobic glycolysis in human gastric carcinoma BGC‐823 cells via NM IIA/EGFR/HK II axis

Author

Shengtao Yuan, Yu Xiaowen, Ruiming Li, Ying-sheng Gao, Jun-Song Wang, Xue-Jun Luo, Dandan Wei, Boyang Yu, Chang-Min Qian, Hongzhi Du, and Li Sun

Subjects
0301 basic medicine, Magnetic Resonance Spectroscopy, Mitochondrion, Small hairpin RNA, Mice, 0302 clinical medicine, Hexokinase, Antineoplastic Combined Chemotherapy Protocols, Epidermal growth factor receptor, RNA, Small Interfering, Cyclic AMP Response Element-Binding Protein, Mice, Inbred BALB C, biology, Chemistry, Nonmuscle Myosin Type IIA, Drug Synergism, Endocytosis, Mitochondria, ErbB Receptors, 030220 oncology & carcinogenesis, NM IIA, Molecular Medicine, Original Article, Female, Glycolysis, medicine.drug, Combination therapy, EGFR, Mice, Nude, TPT, 03 medical and health sciences, Stomach Neoplasms, In vivo, Cell Line, Tumor, medicine, Animals, Humans, aerobic glycolysis, gastric cancer, Carcinoma, Original Articles, Cell Biology, Saponins, Xenograft Model Antitumor Assays, In vitro, 030104 developmental biology, DT‐13, Anaerobic glycolysis, Cancer research, biology.protein, Topotecan
Abstract

DT‐13 combined with topotecan (TPT) showed stronger antitumour effects in mice subcutaneous xenograft model compared with their individual effects in our previous research. Here, we further observed the synergistically effect in mice orthotopic xenograft model. Metabolomics analysis showed DT‐13 combined with TPT alleviated metabolic disorders induced by tumour and synergistically inhibited the activity of the aerobic glycolysis‐related enzymes in vivo and in vitro. Mechanistic studies revealed that the combination treatment promoted epidermal growth factor receptor (EGFR) degradation through non‐muscle myosin IIA (NM IIA)‐induced endocytosis of EGFR, further inhibited the activity of hexokinase II (HK II), and eventually promoted the aerobic glycolysis inhibition activity more efficiently compared with TPT or DT‐13 monotherapy. The combination therapy also inhibited the specific binding of HK II to mitochondria. When using the NM II inhibitor (‐)002Dblebbistatin or MYH‐9 shRNA, the synergistic inhibition effect of DT‐13 and TPT on aerobic glycolysis was eliminated in BGC‐823 cells. Immunohistochemical analysis revealed selective up‐regulation of NM IIA while specific down‐regulation of p‐CREB, EGFR, and HK II by the combination therapy. Collectively, these findings suggested that this regimen has significant clinical implications, warranted further investigation.

Published
2019
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19. 4D Printing of Multi‐Responsive Membrane for Accelerated In Vivo Bone Healing Via Remote Regulation of Stem Cell Fate

Author

You, Dongqi, primary, Chen, Guancong, additional, Liu, Chao, additional, Ye, Xin, additional, Wang, Shaolong, additional, Dong, Minyi, additional, Sun, Mouyuan, additional, He, Jianxiang, additional, Yu, Xiaowen, additional, Ye, Guanchen, additional, Li, Qi, additional, Wu, Junjie, additional, Wu, Jingjun, additional, Zhao, Qian, additional, Xie, Tao, additional, Yu, Mengfei, additional, and Wang, Huiming, additional

Published
2021
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26. Effects of different natural products in patients with non-alcoholic fatty liver disease-A network meta-analysis of randomized controlled trials.

Author

Liu H, Li Y, Jin Y, Li X, Wang D, Yu X, Jiang Z, Yin G, Chen S, Zhang X, Meng D, Yu W, Jiang W, and Zhang F

Subjects
Humans, Biological Products therapeutic use, Biological Products pharmacology, Aspartate Aminotransferases blood, Alanine Transaminase blood, Cynara scolymus chemistry, Cholesterol, LDL blood, Plant Leaves chemistry, Non-alcoholic Fatty Liver Disease drug therapy, Randomized Controlled Trials as Topic, Network Meta-Analysis, Plant Extracts pharmacology, Plant Extracts therapeutic use
Abstract

Due to a scarcity of appropriate therapeutic approaches capable of ameliorating or eliminating non-alcoholic fatty liver disease (NAFLD), many researchers have come to focus on natural products based on traditional medicine that can be utilized to successfully treat NAFLD. In this study, we aimed to evaluate the effects exerted by seven natural products (curcumin, silymarin, resveratrol, artichoke leaf extract, berberine, catechins, and naringenin) on patients with NAFLD. For this purpose, PubMed, Embase, Cochrane Library, and Web of Science, were searched for randomized controlled trials (RCTs) exclusively. The selected studies were evaluated for methodological quality via the Cochrane bias risk assessment tool, and data analysis software was used to analyze the data accordingly. The RCTs from the earliest available date until September 2022 were collected. This process resulted in 37 RCTs with a total sample size of 2509 patients being included. The results of the network meta-analysis showed that artichoke leaf extract confers a relative advantage in reducing the aspartate aminotransferase (AST) levels (SUCRA: 99.1%), alanine aminotransferase (ALT) levels (SUCRA: 88.2%) and low-density lipoprotein cholesterol (LDL-C) levels (SUCRA: 88.9%). Naringenin conferred an advantage in reducing triglyceride (TG) levels (SUCRA: 97.3%), total cholesterol (TC) levels (SUCRA: 73.9%), and improving high-density lipoprotein cholesterol (HDL-C) levels (SUCRA: 74.9%). High-density catechins significantly reduced body mass index (BMI) levels (SUCRA: 98.5%) compared with the placebo. The Ranking Plot of the Network indicated that artichoke leaf extract and naringenin performed better than the other natural products in facilitating patient recovery. Therefore, we propose that artichoke leaf extract and naringenin may exert a better therapeutic effect on NAFLD. This study may help guide clinicians and lead to further detailed studies., (© 2024 John Wiley & Sons Ltd.)

Published
2024
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27. miRNA-211-5p inhibition enhances the protective effect of hucMSC-derived exosome in Aβ 1-40 -induced SH-SY5Y cells by increasing NEP expression.

Author

Chen H, Huang Z, Lei A, Yu X, Shen M, and Wu D

Subjects
Humans, Umbilical Cord metabolism, Exosomes metabolism, Neuroblastoma metabolism, MicroRNAs genetics, MicroRNAs metabolism, Mesenchymal Stem Cells metabolism, Alzheimer Disease therapy, Alzheimer Disease metabolism
Abstract

Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) could alleviate Alzheimer's disease (AD) defects. Additionally, engineered exosomes are more effective in treating diseases. In this study, we established an in vitro model of AD by treating SH-SY5Y cells with Aβ 1-40 . We observed that incubation with hucMSC-derived exosomes effectively protected SH-S5Y5 cells from Aβ 1-40 -induced damage. Since NEP plays a central role in suppressing AD development, we screened NEP-targeting miRNAs that are differentially expressed in control and AD patients. We identified miR-211-5p as a potent repressor of NEP expression. Exosomes purified from hucMSCs overexpressing miR-211-5p inhibitor exhibited significantly greater efficiency than control exosomes in mitigating the injury caused by Aβ 1-40 treatment. However, this enhanced protective effect was nullified by the knockdown of NEP. These observations demonstrate that inhibition of miR-211-5p has the potential to improve the efficacy of hucMSC-derived exosomes in AD treatment by increasing NEP expression., (© 2023 The Authors. Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.)

Published
2024
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