1. Surgical histopathologic findings of 232 Chinese children cases with drug‐resistant seizures
- Author
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Yao Kun, Duan Zejun, Zhou Jian, Zhai Feng, Liu Changqing, and Qi Xueling
- Subjects
drug‐resistant seizures ,focal cortical dysplasia ,histopathologic findings ,seizure outcome ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Objectives The drug‐resistant seizures are characterized by frequent and severe onset of seizures in childhood. There is only little literature had extensively explored the types of pathological brain damage in Chinese children cases. The present study aims to investigate the histopathologic findings and seizure outcomes of drug‐resistant seizures in cases of 0–14‐year‐old children. Materials and Methods About 232 children cases were retrospectively who underwent epilepsy surgery. The medical records, onset age, age of surgery, disease course, seizure type, pathological reports, and seizure outcomes of these patients were retrospectively analyzed. Results The most common categories were malformations of cortical development (focal cortical dysplasia (FCD) was the most common type (94.36%, 67/71), found in 30.60% of the patients, tumors in 18.11%, glial scar in 12.50%, and encephalitis in 11.63%). It was found that the effective seizure outcome of FCD cases with shorter duration of epilepsy (
- Published
- 2020
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