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36 results on '"Zhang, Shuyang"'

6. Natural variation in Tiller Number 1 affects its interaction with TIF1 to regulate tillering in rice

Author

Zhang, Quan, primary, Xie, Jianyin, additional, Zhu, Xiaoyang, additional, Ma, Xiaoqian, additional, Yang, Tao, additional, Khan, Najeeb Ullah, additional, Zhang, Shuyang, additional, Liu, Miaosong, additional, Li, Lin, additional, Liang, Yuntao, additional, Pan, Yinghua, additional, Li, Danting, additional, Li, Jinjie, additional, Li, Zichao, additional, Zhang, Hongliang, additional, and Zhang, Zhanying, additional

Published
2023
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9. First‐line immunotherapy or angiogenesis inhibitor combined with chemotherapy for advanced non‐small cell lung cancer with EGFR exon 20 insertions: Real‐world evidence from China

Author

Yang, Guangjian, primary, Yang, Yaning, additional, Liu, Runze, additional, Li, Weihua, additional, Xu, Haiyan, additional, Hao, Xuezhi, additional, Li, Junling, additional, Zhang, Shuyang, additional, Xu, Fei, additional, Lei, Siyu, additional, and Wang, Yan, additional

Published
2022
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10. Application of an iPSC‐Derived Organoid Model for Localized Scleroderma Therapy (Adv. Sci. 16/2022)

Author

Ma, Jie, primary, Li, Wei, additional, Cao, Ruiyuan, additional, Gao, Dunqin, additional, Zhang, Qiyu, additional, Li, Xiao, additional, Li, Biyou, additional, Lv, Luye, additional, Li, Mansheng, additional, Jiang, Junyi, additional, Wang, Yujie, additional, Li, Jun, additional, Wu, Zhihong, additional, Zhu, Yunping, additional, Zhong, Wu, additional, Zhang, Shuyang, additional, and Leng, Ling, additional

Published
2022
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11. Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection (Adv. Sci. 7/2022)

Author

Ma, Jie, primary, liu, Jia, additional, Gao, Dunqin, additional, Li, Xiao, additional, Zhang, Qiyu, additional, Lv, Luye, additional, Wang, Yujie, additional, Li, Jun, additional, Zhu, Yunping, additional, Wu, Zhihong, additional, Hu, Hengrui, additional, Li, Yufeng, additional, Ma, Longda, additional, Liu, Qian, additional, Hu, Zhihong, additional, Zhang, Shuyang, additional, Zhou, Yiwu, additional, Wang, Manli, additional, and Leng, Ling, additional

Published
2022
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12. Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection

Author

Ma, Jie, primary, liu, Jia, additional, Gao, Dunqin, additional, Li, Xiao, additional, Zhang, Qiyu, additional, Lv, Luye, additional, Wang, Yujie, additional, Li, Jun, additional, Zhu, Yunping, additional, Wu, Zhihong, additional, Hu, Hengrui, additional, Li, Yufeng, additional, Ma, Longda, additional, Liu, Qian, additional, Hu, Zhihong, additional, Zhang, Shuyang, additional, Zhou, Yiwu, additional, Wang, Manli, additional, and Leng, Ling, additional

Published
2021
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14. Lipid goal attainment in post‐acute coronary syndrome patients in China: Results from the 6‐month real‐world dyslipidemia international study II

Author

Gong, Yanjun, primary, Li, Xuan, additional, Ma, Xiang, additional, Yu, Hongwei, additional, Li, Ying, additional, Chen, Jiyan, additional, Zhang, Guochun, additional, Wang, Bin, additional, Qi, Xiaoyong, additional, Meng, Haiyan, additional, Wang, Xiaofeng, additional, Mu, Jianjun, additional, Hu, Xitian, additional, Wang, Jingping, additional, Liu, Shaowen, additional, Liu, Gang, additional, Yang, Zhenyu, additional, Zhou, Yujie, additional, Kong, Xiangqing, additional, Yan, Yuhu, additional, Wang, Changqian, additional, Wang, Jian' An, additional, Wang, Lijun, additional, Fu, Guosheng, additional, Wei, Lin, additional, Peng, Daoquan, additional, Zhang, Shuyang, additional, Li, Ruogu, additional, Mao, Anhua, additional, Bian, Rui, additional, Tang, Wenmin, additional, Ran, Yuqin, additional, Jiang, Jie, additional, and Huo, Yong, additional

Published
2021
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18. Antiphospholipid Antibodies in Critically Ill Patients With COVID‐19

Author

Xiao, Meng, primary, Zhang, Yan, additional, Zhang, Shulan, additional, Qin, Xuzhen, additional, Xia, Peng, additional, Cao, Wei, additional, Jiang, Wei, additional, Chen, Huan, additional, Ding, Xin, additional, Zhao, Hua, additional, Zhang, Hongmin, additional, Wang, Chunyao, additional, Zhao, Jing, additional, Sun, Xuefeng, additional, Tian, Ran, additional, Wu, Wei, additional, Wu, Dong, additional, Ma, Jie, additional, Chen, Yu, additional, Zhang, Dong, additional, Xie, Jing, additional, Yan, Xiaowei, additional, Zhou, Xiang, additional, Liu, Zhengyin, additional, Wang, Jinglan, additional, Du, Bin, additional, Qin, Yan, additional, Gao, Peng, additional, Lu, Minya, additional, Hou, Xin, additional, Wu, Xian, additional, Zhu, Huadong, additional, Xu, Yingchun, additional, Zhang, Wen, additional, Li, Taisheng, additional, Zhang, Fengchun, additional, Zhao, Yongqiang, additional, Li, Yongzhe, additional, and Zhang, Shuyang, additional

Published
2020
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21. Management of heart failure patients withCOVID‐19: a joint position paper of the Chinese Heart Failure Association & National Heart Failure Committee and the Heart Failure Association of the European Society of Cardiology

Author

Zhang, Yuhui, primary, Coats, Andrew J.S., additional, Zheng, Zhe, additional, Adamo, Marianna, additional, Ambrosio, Giuseppe, additional, Anker, Stefan D., additional, Butler, Javed, additional, Xu, Dingli, additional, Mao, Jingyuan, additional, Khan, Muhammad Shahzeb, additional, Bai, Ling, additional, Mebazaa, Alexandre, additional, Ponikowski, Piotr, additional, Tang, Qizhu, additional, Ruschitzka, Frank, additional, Seferovic, Petar, additional, Tschöpe, Carsten, additional, Zhang, Shuyang, additional, Gao, Chuanyu, additional, Zhou, Shenghua, additional, Senni, Michele, additional, Zhang, Jian, additional, and Metra, Marco, additional

Published
2020
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23. A risk score to predict postdischarge bleeding among acute coronary syndrome patients undergoing percutaneous coronary intervention: BRIC‐ACS study

Author

Chen, Yundai, primary, Yin, Tong, additional, Xi, Shaozhi, additional, Zhang, Shuyang, additional, Yan, Hongbing, additional, Tang, Yida, additional, Qian, Juying, additional, Chen, Jiyan, additional, Su, Xi, additional, Du, Zhimin, additional, Wang, Lefeng, additional, Qin, Qin, additional, Gao, Chuanyu, additional, Zheng, Yang, additional, Zhao, Xianxian, additional, Cheng, Xiaoshu, additional, Li, Zhanquan, additional, Zhang, Wenqi, additional, Chen, Hui, additional, Wang, Jingping, additional, Yang, Zhiming, additional, Li, Hui, additional, Liu, Heping, additional, Zhou, Xuchen, additional, Qu, Baiming, additional, Xiang, Dingcheng, additional, Guo, Ying, additional, Wang, Lin, additional, Nie, Shaoping, additional, Fu, Guosheng, additional, Yang, Ming, additional, and Cai, Shanglang, additional

Published
2019
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33. The prevalence and prognosis of asymptomatic intracranial atherosclerosis in a community-based population: Results based on high-resolution magnetic resonance imaging.

Author

Li S, Tang M, Zhang D, Han F, Zhou L, Yao M, Li M, Cui L, Zhang S, Peng B, Jin Z, Zhu Y, and Ni J

Subjects
Humans, Female, Male, Constriction, Pathologic pathology, Prevalence, Prospective Studies, Magnetic Resonance Imaging methods, Prognosis, Stroke diagnostic imaging, Stroke epidemiology, Stroke complications, Plaque, Atherosclerotic complications, Ischemic Stroke complications, Intracranial Arteriosclerosis diagnostic imaging, Intracranial Arteriosclerosis epidemiology
Abstract

Background and Purpose: Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke in China, but the prevalence and prognosis of asymptomatic ICAD detected using high-resolution magnetic resonance imaging (HR-MRI) is largely unknown. The aim of this study was to investigate the prevalence and prognosis in order to guide neurologists in interpreting ICAD detected on HR-MRI., Methods: We included stroke-free participants from a community-based prospective cohort (Shunyi study participants) who underwent HR-MRI between July 2014 and April 2016. The participants were divided into two groups: those with or without ICAD (ICAD + and ICAD - , respectively). ICAD included intracranial artery stenosis and non-stenotic plaque. The primary outcome was ischemic stroke. Cox proportional hazard models were used to evaluate the association between ICAD and event outcomes., Results: A total of 1060 stroke-free participants evaluated by HR-MRI were included from the Shunyi study. The median age at HR-MRI was 56 years and 64.7% were female. The ICAD prevalence was 36.3% (n = 385). The ICAD + group was older and had more cerebrovascular risk factors. The rates of ischemic stroke in the ICAD - and ICAD + groups were 1.3% (n = 9) and 5.2% (n = 20), respectively, with a median follow-up time of 54 months. ICAD was associated with an increased risk of ischemic stroke in the unadjusted and adjusted Cox models, with hazard ratios of 4.12 (95% confidence interval [CI] 1.87-9.05) and 2.50 (95% CI 1.05-5.94), respectively. The greatest risk of an event outcome was observed in participants with ≥70% stenosis or occlusion. The features of high-risk plaques were also identified., Conclusions: We found that ICAD detected using HR-MRI increases the long-term risk of a first-ever ischemic stroke in a stroke-free population, suggesting that the current primary prevention protocol of stroke awaits further optimization., (© 2023 European Academy of Neurology.)

Published
2023
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34. Validation of diagnostic and predictive biomarkers for hereditary angioedema via plasma N-glycomics.

Author

Zhang Z, Wang X, Gu J, Wu J, Cao Y, Xu Y, Li L, Guan K, Liu P, Yin J, Zhi Y, and Zhang S

Abstract

Background: Hereditary angioedema (HAE) is a rare disease with heterogeneous clinical symptoms. It is vitally important to predict whether an HAE patient will develop severe symptoms in clinical practice, but there are currently no predictive biomarkers for HAE stratification. Plasma N-glycomes are disease-specific and have great potential for the discovery of non-invasive biomarkers. In this study, we profiled the plasma N-glycome of HAE patients from two independent cohorts to identify candidate biomarkers., Methods: Linkage-specific sialylation derivatization combined with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry detection and automated data processing was employed to analyze the plasma N-glycome of two independent type-1 HAE cohorts., Results: HAE patients had abnormal glycan complexity, galactosylation, and α2,3- and α2,6-linked sialylation compared to healthy controls (HC). The classification models based on dysregulated glycan traits could successfully discriminate between HAE and HC with area under the curves (AUCs) being greater than 0.9. Some of the aberrant glycans showed response to therapy. Moreover, we identified a series of glycan traits with strong associations with the occurrence of laryngeal or gastrointestinal angioedema or disease severity score. Predictive models based on these traits could be used to predict disease severity (AUC > 0.9). These results were replicated in an independent cohort., Conclusions: We reported the full plasma N-glycomic signature of HAE for the first time, and identified potential biomarkers. These findings may play a critical role in predicting disease severity and guide the treatment of HAE in clinical practice. Further protein-specific and prospective studies are needed to validate our findings., (© 2021 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.)

Published
2021
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35. Correlation between total homocysteine and cerebral small vessel disease: A Mendelian randomization study.

Author

Cao Y, Su N, Zhang D, Zhou L, Yao M, Zhang S, Cui L, Zhu Y, and Ni J

Subjects
Cohort Studies, Genetic Predisposition to Disease, Genotype, Humans, Mendelian Randomization Analysis, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Cerebral Small Vessel Diseases diagnostic imaging, Cerebral Small Vessel Diseases genetics, Homocysteine
Abstract

Background and Purpose: Cerebral small vessel disease (CSVD) is a clinical imaging syndrome with diverse etiology. Total homocysteine (HCY) level might increase the risk of myocardial and cerebral infarction by damaging the vascular endothelium. We aimed to explore the correlation between total HCY and CSVD imaging burden, based on Mendelian randomization methods., Methods: A total of 1,023 participants of the Shunyi study, a population-based cohort study, were included. Vascular risk factors, total HCY levels and methylenetetrahydrofolate reductase (MTHFR) gene mutations (C677T and A1298C) were examined. CSVD imaging markers, including lacunes, cerebral microbleeds, white matter hyperintensity, enlarged perivascular space and brain parenchymal fraction (BPF) were also assessed., Results: Mutations of C677T were significantly correlated with increased total HCY levels (CC→TT: β = 0.28, p < 0.0001), while mutations of A1298C were correlated with decreased total HCY levels (AA→AC: β = -0.13, p < 0.0001; AA→CC: β = -0.25, p = 0.004). In the Mendelian randomization study, the C677T genotype was significantly associated with lacunes (CC→CT: odds ratio [OR] 2.76, p = 0.008; CC→TT: OR 2.50, p = 0.018), and the A1298C genotype was significantly correlated with BPF (AA→CC: β = 1.32, p = 0.015). Similarly, in multivariate regression analysis, total HCY levels were significantly correlated with lacunes (OR 2.14, p < 0.0001) and negatively correlated with BPF (β = -0.55, p = 0.004). Age, sex and vascular risk factors were adjusted for., Conclusions: Total HCY level was correlated with imaging burden of CSVD, especially with lacunes and brain volume loss. For individuals with risk genetic predisposition, enhanced homocysteine-lowering strategies might be necessary to reduce the risk and progress of CSVD., (© 2020 European Academy of Neurology.)

Published
2021
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36. Management of heart failure patients with COVID-19: a joint position paper of the Chinese Heart Failure Association & National Heart Failure Committee and the Heart Failure Association of the European Society of Cardiology.

Author

Zhang Y, Coats AJS, Zheng Z, Adamo M, Ambrosio G, Anker SD, Butler J, Xu D, Mao J, Khan MS, Bai L, Mebazaa A, Ponikowski P, Tang Q, Ruschitzka F, Seferovic P, Tschöpe C, Zhang S, Gao C, Zhou S, Senni M, Zhang J, and Metra M

Subjects
COVID-19, China, Comorbidity, Coronavirus Infections therapy, Europe, Heart Failure epidemiology, Humans, Pneumonia, Viral therapy, SARS-CoV-2, Betacoronavirus, Cardiology, Coronavirus Infections epidemiology, Disease Management, Heart Failure therapy, Pandemics, Pneumonia, Viral epidemiology, Societies, Medical
Abstract

The coronavirus disease 2019 (COVID-19) pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is causing considerable morbidity and mortality worldwide. Multiple reports have suggested that patients with heart failure (HF) are at a higher risk of severe disease and mortality with COVID-19. Moreover, evaluating and treating HF patients with comorbid COVID-19 represents a formidable clinical challenge as symptoms of both conditions may overlap and they may potentiate each other. Limited data exist regarding comprehensive management of HF patients with concomitant COVID-19. Since these issues pose serious new challenges for clinicians worldwide, HF specialists must develop a structured approach to the care of patients with COVID-19 and be included early in the care of these patients. Therefore, the Heart Failure Association of the European Society of Cardiology and the Chinese Heart Failure Association & National Heart Failure Committee conducted web-based meetings to discuss these unique clinical challenges and reach a consensus opinion to help providers worldwide deliver better patient care. The main objective of this position paper is to outline the management of HF patients with concomitant COVID-19 based on the available data and personal experiences of physicians from Asia, Europe and the United States., (© 2020 European Society of Cardiology.)

Published
2020
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