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Your search keyword '"Ziemer, Mirjana"' showing total 136 results
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136 results on '"Ziemer, Mirjana"'

1. S1‐Leitlinie Talgdrüsenkarzinom

Author

Utikal, Jochen, primary, Nagel, Pia, additional, Müller, Verena, additional, Becker, Jürgen C., additional, Dippel, Edgar, additional, Frisman, Alexander, additional, Gschnell, Martin, additional, Griewank, Klaus, additional, Hadaschik, Eva, additional, Helbig, Doris, additional, Hillen, Uwe, additional, Leiter, Ulrike, additional, Pföhler, Claudia, additional, Krönig, Lisa, additional, Ziemer, Mirjana, additional, and Ugurel, Selma, additional

Published
2024
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2. Atypisches Fibroxanthom und pleomorphes dermales Sarkom – Genexpressionsanalyse im Vergleich zum entdifferenzierten Plattenepithelkarzinom der Haut

Author

Anders, Iris Marie, Schimmelpfennig, Carolin, Wiedemann, Karolin, Löffler, Dennis, Kämpf, Christoph, Blumert, Conny, Reiche, Kristin, Kunz, Manfred, Anderegg, Ulf, Simon, Jan-Christoph, Ziemer, Mirjana, and Publica

Subjects
Entdifferenziertes Plattenepithelkarzinom der Haut, Atypisches Fibroanthom, Dermatology, Pleomorphes dermales Sarkom
Abstract

Hintergrund: Der histogenetische Ursprung des atypischen Fibroxanthoms (AFX) und pleomorphen dermalen Sarkoms (PDS) ist nicht abschließend geklärt. Neben einem fibroblastären Ursprung wird aufgrund starker klinischer, histomorphologischer und molekulargenetischer Ähnlichkeiten zum entdifferenzierten Plattenepithelkarzinom der Haut (cutaneous squamous cell carcinoma, cSCC) eine keratinozytäre Differenzierung diskutiert. Patienten und Methodik: 56 Fälle (36 AFX, 8 PDS, 12 entdifferenzierte cSCC) wurden hinsichtlich ihrer klinischen, histomorphologischen und immunhistochemischen Charakteristika untersucht. An 18 Fällen (6 AFX/PDS, 6 entdifferenzierte cSCC, 6 differenzierte cSCC) wurde eine RNA-Transkriptomanalyse durchgeführt. Ergebnisse: Klinisch bestätigten sich starke Gemeinsamkeiten hinsichtlich Alter, Geschlecht und Lokalisation der Tumoren. Histomorphologisch ist es häufig ohne weiterführende immunhistochemische Färbungen nicht möglich AFX/PDS und entdifferenzierte cSCC voneinander abzugrenzen. In der Hauptkomponentenanalyse der RNA-Transkriptomanalyse konnte gezeigt werden, dass AFX/PDS und differenzierte cSCC jeweils ein eigenes Cluster bildeten, während sich die entdifferenzierten cSCC dazwischen einordneten, ohne ein eigenes Cluster zu bilden. Bei der Betrachtung differenziell exprimierter Gene (DEG) verdeutlichten die Heat Maps, dass es innerhalb der entdifferenzierten cSCC-Fälle gab, welche vom Expressionsprofil eher den AFX/PDS als den differenzierten cSCC zuzuordnen waren. Schlussfolgerungen: Die Ergebnisse der Gesamtuntersuchungen geben Hinweise auf molekulare Ähnlichkeiten zwischen AFX/PDS und entdifferenzierten cSCC und lassen einen gemeinsamen histogenetischen Ursprung vermuten.

Published
2023
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3. Atypical fibroxanthoma and pleomorphic dermal sarcoma – gene expression analysis compared with undifferentiated cutaneous squamous cell carcinoma

Author

Anders, Iris Marie, Schimmelpfennig, Carolin, Wiedemann, Karolin, Löffler, Dennis, Kämpf, Christoph, Blumert, Conny, Reiche, Kristin, Kunz, Manfred, Anderegg, Ulf, Simon, Jan-Christoph, Ziemer, Mirjana, and Publica

Subjects
Atypical fibroxanthoma, Pleomorphic dermal sarcoma, Dermatology, Undifferentiated cutaneous squamous cell carinoma
Abstract

Background: The histogenetic origin of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) has not been definitively elucidated. In addition to a fibroblastic origin, a keratinocytic differentiation is discussed due to strong clinical, histomorphological and molecular genetic similarities with undifferentiated cutaneous squamous cell carcinoma (cSCC). Patients and Methods: 56 cases (36 AFXs, 8 PDSs, 12 undifferentiated cSCCs) were evaluated for their clinical, histomorphological, and immunohistochemical characteristics. RNA transcriptome analysis was performed on 18 cases (6 AFXs/PDSs, 6 undifferentiated cSCCs, 6 differentiated cSCCs). Results: Clinically, the strong similarities in age, gender and tumor location were confirmed. Without further immunohistochemical staining, histomorphological differentiation between AFX/PDS and undifferentiated cSCC is often impossible. Principal component analysis of the RNA transcriptome analysis showed that AFX/PDS and differentiated cSCC each formed their own cluster, while the undifferentiated cSCCs fall in between these two groups, but without forming a cluster of their own. When examining differentially expressed genes (DEGs), the heat maps showed that there were cases within the undifferentiated cSCC that were more likely to be AFX/PDS than differentiated cSCC based on their expression profile. Conclusions: The results provide evidence of molecular similarities between AFX/PDS and undifferentiated cSCC and suggest a common histogenetic origin.

Published
2023
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4. S1‐Leitlinie dermales und subkutanes Leiomyosarkom

Author

Helbig, Doris, primary, Dippel, Edgar, additional, Erdmann, Michael, additional, Frisman, Alexander, additional, Kage, Paula, additional, Leiter, Ulrike, additional, Mentzel, Thomas, additional, Seidel, Clemens, additional, Weishaupt, Carsten, additional, Ziemer, Mirjana, additional, and Ugurel, Selma, additional

Published
2023
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5. Immune checkpoint inhibition and targeted therapy for melanoma: A patient‐oriented cross‐sectional comparative multicentre study

Author

Thiem, Alexander, primary, Mashhadiakbar, Pegah, additional, Cussigh, Christiane, additional, Hassel, Jessica C., additional, Grimmelmann, Imke, additional, Gutzmer, Ralf, additional, Schlaak, Max, additional, Heppt, Markus V., additional, Dücker, Pia, additional, Hüning, Svea, additional, Schulmeyer, Lena, additional, Schilling, Bastian, additional, Haferkamp, Sebastian, additional, Ziemer, Mirjana, additional, Moritz, Rose K. C., additional, Hagelstein, Victoria, additional, Terheyden, Patrick, additional, Posch, Christian, additional, Gaiser, Maria R., additional, Kropp, Peter, additional, Emmert, Steffen, additional, Müller, Britta, additional, and Tietze, Julia K., additional

Published
2022
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8. S1 Guidelines for the Kaposi Sarcoma

Author

Esser, Stefan, primary, Schöfer, Helmut, additional, Hoffmann, Christian, additional, Claßen, Johannes, additional, Kreuter, Alexander, additional, Leiter, Ulrike, additional, Oette, Mark, additional, Becker, Jürgen C., additional, Ziemer, Mirjana, additional, Mosthaf, Franz, additional, Sirokay, Judith, additional, Ugurel, Selma, additional, Potthoff, Anja, additional, Helbig, Doris, additional, Bierhoff, Erhard, additional, Schulz, Thomas F., additional, Brockmeyer, Norbert H., additional, and Grabbe, Stephan, additional

Published
2022
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9. S1‐Leitlinie: Kaposi‐Sarkom

Author

Esser, Stefan, primary, Schöfer, Helmut, additional, Hoffmann, Christian, additional, Claßen, Johannes, additional, Kreuter, Alexander, additional, Leiter, Ulrike, additional, Oette, Mark, additional, Becker, Jürgen C., additional, Ziemer, Mirjana, additional, Mosthaf, Franz, additional, Sirokay, Judith, additional, Ugurel, Selma, additional, Potthoff, Anja, additional, Helbig, Doris, additional, Bierhoff, Erhard, additional, Schulz, Thomas F., additional, Brockmeyer, Norbert H., additional, and Grabbe, Stephan, additional

Published
2022
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12. S1 Guidelines for the Kaposi Sarcoma

Author

Esser, Stefan, Schoefer, Helmut, Hoffmann, Christian, Classen, Johannes, Kreuter, Alexander, Leiter, Ulrike, Oette, Mark, Becker, Juergen C., Ziemer, Mirjana, Mosthaf, Franz, Sirokay, Judith, Ugurel, Selma, Potthoff, Anja, Helbig, Doris, Bierhoff, Erhard, Schulz, Thomas F., Brockmeyer, Norbert H., Grabbe, Stephan, Esser, Stefan, Schoefer, Helmut, Hoffmann, Christian, Classen, Johannes, Kreuter, Alexander, Leiter, Ulrike, Oette, Mark, Becker, Juergen C., Ziemer, Mirjana, Mosthaf, Franz, Sirokay, Judith, Ugurel, Selma, Potthoff, Anja, Helbig, Doris, Bierhoff, Erhard, Schulz, Thomas F., Brockmeyer, Norbert H., and Grabbe, Stephan

Abstract

Kaposi's sarcoma (KS) is a rare, malignant, multilocular vascular disease originating from lymphatic endothelial cells that can primarily affect the skin and mucous membranes, but also the lymphatic system and internal organs such as the gastrointestinal tract, lungs or liver. Five epidemiological subtypes of KS with variable clinical course and prognosis are distinguished, with increased incidence in specific populations: (1) Classical KS, (2) Iatrogenic KS in immunosuppression, (3) Endemic (African) lymphadenopathic KS, (4) Epidemic, HIV-associated KS and KS associated with immune reconstitution inflammatory syndrome (IRIS), and (5) KS in men who have sex with men (MSM) without HIV infection. This interdisciplinary guideline summarizes current practice-relevant recommendations on diangostics and therapy of the different forms of KS. The recommendations mentioned in this short guideline are elaborated in more detail in the extended version of the guideline (online format of the JDDG).

Published
2022

13. S1-guideline atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS)

Author

Helbig, Doris, Ziemer, Mirjana, Dippel, Edgar, Erdmann, Michael, Hillen, Uwe, Leiter, Ulrike, Mentzel, Thomas, Osterhoff, Georg, Ugurel, Selma, Utikal, Jochen, von Bubnoff, Dagmar, Weishaupt, Carsten, Grabbe, Stephan, Helbig, Doris, Ziemer, Mirjana, Dippel, Edgar, Erdmann, Michael, Hillen, Uwe, Leiter, Ulrike, Mentzel, Thomas, Osterhoff, Georg, Ugurel, Selma, Utikal, Jochen, von Bubnoff, Dagmar, Weishaupt, Carsten, and Grabbe, Stephan

Abstract

Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous neoplasms representing histomorphological, genetic as well as epigenetic variants of a disease spectrum. Both tumors typically manifest as nonspecific, often ulcerated, skin- to flesh-colored nodules in chronically sun-damaged skin of elderly male patients. AFX is a rather well demarcated, often rapidly growing tumor. PDS tumors are poorly circumscribed and are characterized by aggressive infiltrative growth. Fast as well as slow growth behavior has been reported for both tumors. Histologically, both are composed of spindle-shaped and epithelioid tumor cells with pleomorphic nuclei as well as atypical multinucleated giant cells. Atypical mitoses are common. In contrast to AFX, PDS involves relevant parts of the subcutis and shows areas of tumor necrosis and/or perineural infiltration. Due to the poorly differentiated nature of AFX/ PDS (Grade 3), histopathologically similar cutaneous sarcomas, undifferentiated carcinomas, melanomas and other diseases have to be excluded by immunohistochemical analysis. The treatment of choice is micrographically controlled surgery. In cases of AFX, a cure can be assumed after complete excision. Local recurrence rates are low as long as PDS tumors are surgically removed with a safety margin of 2 cm. Metastasis is rare and mostly associated with very thick or incompletely excised tumors; it mainly affects the skin and lymph nodes. Distant metastasis is even more rare. No approved and effective systemic therapy has been established.

Published
2022

14. S1‐Leitlinie Atypisches Fibroxanthom (AFX) und pleomorphes dermales Sarkom (PDS)

Author

Helbig, Doris, primary, Ziemer, Mirjana, additional, Dippel, Edgar, additional, Erdmann, Michael, additional, Hillen, Uwe, additional, Leiter, Ulrike, additional, Mentzel, Thomas, additional, Osterhoff, Georg, additional, Ugurel, Selma, additional, Utikal, Jochen, additional, Bubnoff, Dagmar, additional, Weishaupt, Carsten, additional, and Grabbe, Stephan, additional

Published
2022
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15. S1‐guideline atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS)

Author

Helbig, Doris, primary, Ziemer, Mirjana, additional, Dippel, Edgar, additional, Erdmann, Michael, additional, Hillen, Uwe, additional, Leiter, Ulrike, additional, Mentzel, Thomas, additional, Osterhoff, Georg, additional, Ugurel, Selma, additional, Utikal, Jochen, additional, Bubnoff, Dagmar, additional, Weishaupt, Carsten, additional, and Grabbe, Stephan, additional

Published
2022
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21. Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft-versus-host disease

Author

Wegner, Joanna, Weidenthaler-Barth, Beate, Engelbert, Julia, Knothe, Max, Braun, Claudia, Helbig, Doris, Sacher, Christopher, Kreft, Andreas, Wagner, Eva M., Ziemer, Mirjana, Meyer, Ralf G., von Stebut, Esther, Wegner, Joanna, Weidenthaler-Barth, Beate, Engelbert, Julia, Knothe, Max, Braun, Claudia, Helbig, Doris, Sacher, Christopher, Kreft, Andreas, Wagner, Eva M., Ziemer, Mirjana, Meyer, Ralf G., and von Stebut, Esther

Abstract

Graft-versus-host disease (GvHD) is a major complication following stem-cell or solid-organ transplantation. Accurate diagnosis of cutaneous GvHD is challenging, given that drug eruptions and viral rashes may present with similar clinical/histological manifestations. Specific markers are not available. We performed the histological examination of biopsy samples from acute GvHD (aGvHD; n = 54), Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN; n = 27), maculopapular drug eruption (MDE; n = 26) and healthy controls (n = 26). Samples of aGvHD showed a decrease in Langerhans cells (LC, p = 0.0001) and an increase in macrophages (M phi, p = 0.0001) compared to healthy skin. Compared to SJS/TEN, MDE and healthy skin, aGvHD biopsies contained greater numbers of CD4(+) and CD8(+) T cells. The majority of CD4(+) T-helper cells were localized in the upper dermis, whereas cytotoxic CD8(+) T cells were found in the epidermis. Increased numbers of CD56(+) natural killer (NK) cells in the upper dermis of aGvHD skin (p = 0.007) were not observed in controls or SJS/TEN and MDE. There were no differences in elafin staining between aGvHD and the latter two conditions. Acute GvHD appears to have a distinct inflammatory cell profile (T cells/NK cells) that may aid establishing in a more accurate diagnosis, especially when used to rule out differential diagnoses such as SJS/TEN or MDE.

Published
2021

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