Search

Your search keyword '"Zuccato, Cristina"' showing total 7 results
Start Over Author "Zuccato, Cristina" Publisher wiley
7 results on '"Zuccato, Cristina"'

1. Effects of Sirolimus treatment on patients with β‐Thalassemia : Lymphocyte immunophenotype and biological activity of memory CD4 + and CD8 + T cells

Author

Zurlo, Matteo, primary, Nicoli, Francesco, additional, Proietto, Davide, additional, Dallan, Beatrice, additional, Zuccato, Cristina, additional, Cosenza, Lucia Carmela, additional, Gasparello, Jessica, additional, Papi, Chiara, additional, d'Aversa, Elisabetta, additional, Borgatti, Monica, additional, Scapoli, Chiara, additional, Finotti, Alessia, additional, and Gambari, Roberto, additional

Published
2023
Full Text
View/download PDF

2. Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV-A Irradiation of 5-Methoxypsoralen

Author

Salvador, Alessia, primary, Dall'Acqua, Stefano, additional, Sardo, Manlio Sutera, additional, Caffieri, Sergio, additional, Vedaldi, Daniela, additional, Dall'Acqua, Francesco, additional, Borgatti, Monica, additional, Zuccato, Cristina, additional, Bianchi, Nicoletta, additional, and Gambari, Roberto, additional

Published
2010
Full Text
View/download PDF

3. Production of β‐globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous β039 thalassemia patients

Author

Salvatori, Francesca, primary, Breveglieri, Giulia, additional, Zuccato, Cristina, additional, Finotti, Alessia, additional, Bianchi, Nicoletta, additional, Borgatti, Monica, additional, Feriotto, Giordana, additional, Destro, Federica, additional, Canella, Alessandro, additional, Brognara, Eleonora, additional, Lampronti, Ilaria, additional, Breda, Laura, additional, Rivella, Stefano, additional, and Gambari, Roberto, additional

Published
2009
Full Text
View/download PDF

5. Development of K562 cell clones expressing β-globin mRNA carrying the β039 thalassaemia mutation for the screening of correctors of stop-codon mutations

Author

Salvatori, Francesca, primary, Cantale, Vera, additional, Breveglieri, Giulia, additional, Zuccato, Cristina, additional, Finotti, Alessia, additional, Bianchi, Nicoletta, additional, Borgatti, Monica, additional, Feriotto, Giordana, additional, Destro, Federica, additional, Canella, Alessandro, additional, Breda, Laura, additional, Rivella, Stefano, additional, and Gambari, Roberto, additional

Published
2009
Full Text
View/download PDF

7. Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

Author

Breveglieri G, Mancini I, Bianchi N, Lampronti I, Salvatori F, Fabbri E, Zuccato C, Cosenza LC, Montagner G, Borgatti M, Altruda F, Fagoonee S, Carandina G, Rubini M, Aiello V, Breda L, Rivella S, Gambari R, and Finotti A

Subjects
Animals, Base Sequence, Greece, Hemoglobins genetics, Humans, Italy, Mice, Phenotype, Point Mutation, RNA Splicing, beta-Thalassemia pathology, Mice, Transgenic, beta-Globins genetics, beta-Thalassemia genetics
Abstract

Mouse models that carry mutations causing thalassemia represent a suitable tool to test in vivo new mutation-specific therapeutic approaches. Transgenic mice carrying the β-globin IVSI-6 mutation (the most frequent in Middle-Eastern regions and recurrent in Italy and Greece) are, at present, not available. We report the production and characterization of a transgenic mouse line (TG-β-IVSI-6) carrying the IVSI-6 thalassemia point mutation within the human β-globin gene. In the TG-β-IVSI-6 mouse (a) the transgenic integration region is located in mouse chromosome 7; (b) the expression of the transgene is tissue specific; (c) as expected, normally spliced human β-globin mRNA is produced, giving rise to β-globin production and formation of a human-mouse tetrameric chimeric hemoglobin (mu) α-globin2/(hu) β-globin2 and, more importantly, (d) the aberrant β-globin-IVSI-6 RNAs are present in blood cells. The TG-β-IVSI-6 mouse reproduces the molecular features of IVSI-6 β-thalassemia and might be used as an in vivo model to characterize the effects of antisense oligodeoxynucleotides targeting the cryptic sites responsible for the generation of aberrantly spliced β-globin RNA sequences, caused by the IVSI-6 mutation. These experiments are expected to be crucial for the development of a personalized therapy for β-thalassemia.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results