9 results on '"de Francesco, D."'
Search Results
2. Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls
- Author
-
De Francesco, D., Underwood, J., Bagkeris, E., Boffito, M., Post, F. A., Mallon, P. W. G., Vera, J. H., Williams, I., Anderson, J., Johnson, M., Sabin, C. A., Winston, A., Babalis, Daphne, Boffito, Marta, Burgess, Laura, Mallon, Paddy, Sabin, Caroline, Sachikonye, Memory, Winston, Alan, Asboe, David, Garvey, Lucy, Pozniak, Anton, Clarke, Amanda, Vera, Jaime, Bexley, Andrew, Richardson, Celia, Kirk, Sarah, Gleig, Rebecca, Bracchi, Margherita, Pagani, Nicole, Cerrone, Maddalena, Bradshaw, Daniel, Ferretti, Francesca, Higgs, Chris, Seah, Elisha, Fletcher, Stephen, Anthonipillai, Michelle, Moyes, Ashley, Deats, Katie, Syed, Irtiza, Matthews, Clive, Fernando, Peter, Chiwome, Chido, Hardwick, Shane, Anderson, Jane, Mguni, Sifiso, Clark, Rebecca, Nevin-Dolan, Rhiannon, Pelluri, Sambasivarao, Post, Frank, Campbell, Lucy, Yurdakul, Selin, Okumu, Sara, Pollard, Louise, Santana-Suarez, Beatriz, Macken, Alan, Ghavani-Kia, Bijan, Maher, Joanne, Byrne, Maria, Flaherty, Ailbhe, Babu, Sumesh, Otiko, Damilola, Phillips, Laura, Laverick, Rosanna, Beynon, Michelle, Salz, Anna-Lena, Severn, Abigail, Tembo, Lavender, Stott, Matthew, McDonald, Linda, Dransfield, Felix, Whitehouse, Andrew, Ngwu, Nnenna, Hemat, Nargis, Jones, Martin, Carroll, Anne, Kinloch, Sabine, Youle, Mike, and Madge, Sara
- Subjects
0301 basic medicine ,Adult ,Male ,Substance-Related Disorders ,HIV Infections ,Hashish ,RC0109 ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cognition ,cognitive disorder ,medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Effects of sleep deprivation on cognitive performance ,people living with HIV ,Life Style ,Depression (differential diagnoses) ,cognitive function ,Aged ,Original Research ,Depressive Disorder ,business.industry ,Health Policy ,Cognitive disorder ,HIV ,Middle Aged ,medicine.disease ,Recreational drug use ,030112 virology ,Mental health ,Patient Health Questionnaire ,Infectious Diseases ,Cross-Sectional Studies ,HIV‐associated neurocognitive disorders ,depression ,Female ,business ,medicine.drug ,Demography - Abstract
Objectives\ud We investigated whether differences in cognitive performance between people living with HIV (PLWH) and comparable HIV‐negative people were mediated or moderated by depressive symptoms and lifestyle factors.\ud \ud Methods\ud A cross‐sectional study of 637 ‘older’ PLWH aged ≥ 50 years, 340 ‘younger’ PLWH aged < 50 years and 276 demographically matched HIV‐negative controls aged ≥ 50 years enrolled in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study was performed. Cognitive function was assessed using a computerized battery (CogState). Scores were standardized into Z‐scores [mean = 0; standard deviation (SD) = 1] and averaged to obtain a global Z‐score. Depressive symptoms were evaluated via the Patient Health Questionnaire (PHQ‐9). Differences between the three groups and the effects of depression, sociodemographic factors and lifestyle factors on cognitive performance were evaluated using median regression. All analyses accounted for age, gender, ethnicity and level of education.\ud \ud Results\ud After adjustment for sociodemographic factors, older and younger PLWH had poorer overall cognitive scores than older HIV‐negative controls (P < 0.001 and P = 0.006, respectively). Moderate or severe depressive symptoms were more prevalent in both older (27%; P < 0.001) and younger (21%; P < 0.001) PLWH compared with controls (8%). Depressive symptoms (P < 0.001) and use of hashish (P = 0.01) were associated with lower cognitive function; alcohol consumption (P = 0.02) was associated with better cognitive scores. After further adjustment for these factors, the difference between older PLWH and HIV‐negative controls was no longer significant (P = 0.08), while that between younger PLWH and older HIV‐negative controls remained significant (P = 0.01).\ud \ud Conclusions\ud Poorer cognitive performances in PLWH compared with HIV‐negative individuals were, in part, mediated by the greater prevalence of depressive symptoms and recreational drug use reported by PLWH.
- Published
- 2019
3. CHEMOTHERAPY IN HIV-POSITIVE PATIENTS WITH NON-HODGKIN LYMPHOMA: A SINGLE INSTITUTION RETROSPECTIVE STUDY
- Author
-
Dalu, D., primary, Fasola, C., additional, Bombonati, G., additional, and De Francesco, D., additional
- Published
- 2019
- Full Text
- View/download PDF
4. Medicalising normality? Using a simulated dataset to assess the performance of different diagnostic criteria of cognitive impairment
- Author
-
Underwood, J, Leech, R, Winston, A, Sabin, C, and De Francesco, D
- Subjects
Science & Technology ,Infectious Diseases ,Virology ,1103 Clinical Sciences ,Life Sciences & Biomedicine - Published
- 2017
5. Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV
- Author
-
Underwood, J, De Francesco, D, Post, FA, Vera, JH, Williams, I, Boffito, M, Mallon, PW, Anderson, J, Sachikonye, M, Sabin, C, Winston, A, and Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study group
- Subjects
Gerontology ,Male ,Activities of daily living ,HIV Infections ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Acquired immunodeficiency syndrome (AIDS) ,Surveys and Questionnaires ,Virology ,Medicine ,Dementia ,Humans ,Pharmacology (medical) ,Cognitive Dysfunction ,030212 general & internal medicine ,Prospective Studies ,VALIDITY ,Depression (differential diagnoses) ,Aged ,cognitive impairment ,Aged, 80 and over ,Science & Technology ,business.industry ,Health Policy ,HIV ,1103 Clinical Sciences ,Middle Aged ,medicine.disease ,Mental health ,3. Good health ,NEUROPSYCHOLOGICAL IMPAIRMENT ,Sexual desire ,Infectious Diseases ,patient-reported outcomes ,Normative ,Female ,business ,activities of daily living ,Life Sciences & Biomedicine ,030217 neurology & neurosurgery - Abstract
Objectives: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear.\ud \ud Methods: We tested cognitive function using a computerized battery (CogState™) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 years participating in the Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study. Participants completed questionnaires detailing physical and mental health [Short Form Health Survey (SF-36)], cognitive function [European AIDS Clinical Society (EACS) questions], activities of daily living [Lawton Instrumental Activities of Daily Living (IADL)], depression [Patient Depression Questionnaire (PHQ-9) and Centres for Epidemiologic Studies Depression scale (CES-D)], falls and sexual desire. Cognitive impairment was defined using the Frascati criteria, global deficit score (GDS) and multivariate normative comparison (MNC). In the HIV-positive group, the classification performances of the different definitions of cognitive impairment and dichotomized questionnaire results were calculated.\ud \ud Results: The prevalence of cognitive impairment in the HIV-positive group was 34.5% (GDS), 30.0% (Frascati) and 22.1% (MNC), with only 2% diagnosed with HIV-associated dementia. In general, the associations between cognitive impairment and PROMs were weak regardless of the definition used: mean c-statistics were 0.543 (GDS), 0.530 (MNC) and 0.519 (Frascati). Associations were similar using the global T-score to define cognitive impairment. Summary health scores (SF-36) were lower, but only significantly so for those with cognitive impairment identified using MNC, for both mental health (61.4 vs. 75.8; P = 0.03) and physical health (60.9 vs. 75.0; P = 0.03).\ud \ud Conclusions: The associations between cognitive impairment and PROMs were weak, possibly because impairment was mild and therefore largely asymptomatic. Further work is needed to elucidate the clinical implications of cognitive impairment in HIV-disease.
- Published
- 2016
6. Brain MRI changes associated with poorer cognitive function despite suppressive antiretroviral therapy
- Author
-
Underwood, J, Cole, JH, Sharp, D, Winston, A, Leech, R, Majoie, C, Caan, M, De Francesco, D, Van Zoest, R, Geurtsen, G, Schmand, B, Wit, F, Reiss, P, Sabin, C, and Commission of the European Communities
- Subjects
Science & Technology ,Infectious Diseases ,Virology ,1103 Clinical Sciences ,Life Sciences & Biomedicine - Published
- 2016
7. Antiretroviral central nervous system toxicity
- Author
-
Underwood, J., De Francesco, D., Cole, J., Wit, F., Sharp, D., Sabin, C., Reiss, P., Winston, A., Underwood, J., De Francesco, D., Cole, J., Wit, F., Sharp, D., Sabin, C., Reiss, P., and Winston, A.
8. Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls.
- Author
-
De Francesco D, Underwood J, Bagkeris E, Boffito M, Post FA, Mallon P, Vera JH, Williams I, Anderson J, Johnson M, Sabin CA, and Winston A
- Subjects
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Substance-Related Disorders psychology, Young Adult, Cognition, Depressive Disorder psychology, HIV Infections psychology, Life Style
- Abstract
Objectives: We investigated whether differences in cognitive performance between people living with HIV (PLWH) and comparable HIV-negative people were mediated or moderated by depressive symptoms and lifestyle factors., Methods: A cross-sectional study of 637 'older' PLWH aged ≥ 50 years, 340 'younger' PLWH aged < 50 years and 276 demographically matched HIV-negative controls aged ≥ 50 years enrolled in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study was performed. Cognitive function was assessed using a computerized battery (CogState). Scores were standardized into Z-scores [mean = 0; standard deviation (SD) = 1] and averaged to obtain a global Z-score. Depressive symptoms were evaluated via the Patient Health Questionnaire (PHQ-9). Differences between the three groups and the effects of depression, sociodemographic factors and lifestyle factors on cognitive performance were evaluated using median regression. All analyses accounted for age, gender, ethnicity and level of education., Results: After adjustment for sociodemographic factors, older and younger PLWH had poorer overall cognitive scores than older HIV-negative controls (P < 0.001 and P = 0.006, respectively). Moderate or severe depressive symptoms were more prevalent in both older (27%; P < 0.001) and younger (21%; P < 0.001) PLWH compared with controls (8%). Depressive symptoms (P < 0.001) and use of hashish (P = 0.01) were associated with lower cognitive function; alcohol consumption (P = 0.02) was associated with better cognitive scores. After further adjustment for these factors, the difference between older PLWH and HIV-negative controls was no longer significant (P = 0.08), while that between younger PLWH and older HIV-negative controls remained significant (P = 0.01)., Conclusions: Poorer cognitive performances in PLWH compared with HIV-negative individuals were, in part, mediated by the greater prevalence of depressive symptoms and recreational drug use reported by PLWH., (© 2019 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.)
- Published
- 2019
- Full Text
- View/download PDF
9. Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV.
- Author
-
Underwood J, De Francesco D, Post FA, Vera JH, Williams I, Boffito M, Mallon PW, Anderson J, Sachikonye M, Sabin C, and Winston A
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Activities of Daily Living, Cognition, Cognitive Dysfunction diagnosis, HIV Infections complications
- Abstract
Objectives: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear., Methods: We tested cognitive function using a computerized battery (CogState
™ ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 years participating in the Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study. Participants completed questionnaires detailing physical and mental health [Short Form Health Survey (SF-36)], cognitive function [European AIDS Clinical Society (EACS) questions], activities of daily living [Lawton Instrumental Activities of Daily Living (IADL)], depression [Patient Depression Questionnaire (PHQ-9) and Centres for Epidemiologic Studies Depression scale (CES-D)], falls and sexual desire. Cognitive impairment was defined using the Frascati criteria, global deficit score (GDS) and multivariate normative comparison (MNC). In the HIV-positive group, the classification performances of the different definitions of cognitive impairment and dichotomized questionnaire results were calculated., Results: The prevalence of cognitive impairment in the HIV-positive group was 34.5% (GDS), 30.0% (Frascati) and 22.1% (MNC), with only 2% diagnosed with HIV-associated dementia. In general, the associations between cognitive impairment and PROMs were weak regardless of the definition used: mean c-statistics were 0.543 (GDS), 0.530 (MNC) and 0.519 (Frascati). Associations were similar using the global T-score to define cognitive impairment. Summary health scores (SF-36) were lower, but only significantly so for those with cognitive impairment identified using MNC, for both mental health (61.4 vs. 75.8; P = 0.03) and physical health (60.9 vs. 75.0; P = 0.03)., Conclusions: The associations between cognitive impairment and PROMs were weak, possibly because impairment was mild and therefore largely asymptomatic. Further work is needed to elucidate the clinical implications of cognitive impairment in HIV-disease., (© 2016 British HIV Association.)- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.