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Your search keyword '"de Lange, Eduard E."' showing total 30 results
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30 results on '"de Lange, Eduard E."'

4. Rapid acquisition of helium-3 and proton three-dimensional image sets of the human lung in a single breath-hold using compressed sensing

Author

Qing, Kun, primary, Altes, Talissa A., additional, Tustison, Nicholas J., additional, Feng, Xue, additional, Chen, Xiao, additional, Mata, Jaime F., additional, Miller, G. Wilson, additional, de Lange, Eduard E., additional, Tobias, William A., additional, Cates, Gordon D., additional, Brookeman, James R., additional, and Mugler, John P., additional

Published
2014
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18. MRI of the lungs using hyperpolarized noble gases

Author

Möller, Harald E., primary, Chen, X. Josette, additional, Saam, Brian, additional, Hagspiel, Klaus D., additional, Johnson, G. Allan, additional, Altes, Talissa A., additional, de Lange, Eduard E., additional, and Kauczor, Hans-Ulrich, additional

Published
2002
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22. A multisite phase III study of the safety and efficacy of a new manganese chloride-based gastrointestinal contrast agent for MRI of the abdomen and pelvis

Author

Small, William C., primary, DeSimone-Macchi, Debra, additional, Parker, John R., additional, Sukerkar, Arun, additional, Hahn, Peter F., additional, Rubin, Daniel L., additional, Zelch, James V., additional, Kuhlman, Janet E., additional, Outwater, Eric K., additional, Weinreb, Jeffrey C., additional, Brown, Jeffrey J., additional, de Lange, Eduard E., additional, Woodward, Paula J., additional, Arildsen, Ronald, additional, Foster, Gregory S., additional, Runge, Val M., additional, Aisen, Alex M., additional, Muroff, Lawrence R., additional, Thoeni, Ruedi F., additional, Parisky, Yuri R., additional, Tanenbaum, Lawrence N., additional, Totterman, Saara, additional, Herfkens, Robert J., additional, Knudsen, John, additional, Laster, Jr., Robert E., additional, Duerinckx, Andre, additional, Stillman, Arthur E., additional, Spritzer, Charles E., additional, Saini, Sanjay, additional, Rofsky, Neil M., additional, and Bernardino, Michael E., additional

Published
1999
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23. Safety profile of ultrasmall superparamagnetic iron oxide ferumoxtran‐10: Phase II clinical trial data

Author

Sharma, Raju, primary, Saini, Sanjay, additional, Ros, Pablo R., additional, Hahn, Peter F., additional, Small, William C., additional, de Lange, Eduard E., additional, Stillman, Arthur E., additional, Edelman, Robert R., additional, Runge, Val M., additional, Outwater, Eric K., additional, Morris, Marie, additional, and Lucas, Maria, additional

Published
1999
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24. MR imaging and spectroscopy using hyperpolarized 129Xe gas: Preliminary human results

Author

Mugler, John P., primary, Driehuys, Bastiaan, additional, Brookeman, James R., additional, Cates, Gordon D., additional, Berr, Stuart S., additional, Bryant, Robert G., additional, Daniel, Thomas M., additional, De Lange, Eduard E., additional, Downs, J. Hunter, additional, Erickson, Christopher J., additional, Happer, William, additional, Hinton, Denise P., additional, Kassel, Neal F., additional, Maier, Therese, additional, Phillips, C. Douglas, additional, Saam, Brian T., additional, Sauer, Karen L., additional, and Wagshul, Mark E., additional

Published
1997
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26. Signal-to-noise ratio, T 2 , and T2* for hyperpolarized helium-3 MRI of the human lung at three magnetic field strengths.

Author

Komlosi P, Altes TA, Qing K, Mooney KE, Miller GW, Mata JF, de Lange EE, Tobias WA, Cates GD Jr, and Mugler JP 3rd

Subjects
Administration, Inhalation, Adult, Helium administration & dosage, Humans, Isotopes administration & dosage, Magnetic Fields, Signal-To-Noise Ratio, Young Adult, Helium chemistry, Image Processing, Computer-Assisted methods, Isotopes chemistry, Lung diagnostic imaging, Magnetic Resonance Imaging methods, Signal Processing, Computer-Assisted
Abstract

Purpose: To evaluate T 2 , T2*, and signal-to-noise ratio (SNR) for hyperpolarized helium-3 ( 3 He) MRI of the human lung at three magnetic field strengths ranging from 0.43T to 1.5T., Methods: Sixteen healthy volunteers were imaged using a commercial whole body scanner at 0.43T, 0.79T, and 1.5T. Whole-lung T 2 values were calculated from a Carr-Purcell-Meiboom-Gill spin-echo-train acquisition. T2* maps and SNR were determined from dual-echo and single-echo gradient-echo images, respectively. Mean whole-lung SNR values were normalized by ventilated lung volume and administered 3 He dose., Results: As expected, T 2 and T2* values demonstrated a significant inverse relationship to field strength. Hyperpolarized 3 He images acquired at all three field strengths had comparable SNR values and thus appeared visually very similar. Nonetheless, the relatively small SNR differences among field strengths were statistically significant., Conclusions: Hyperpolarized 3 He images of the human lung with similar image quality were obtained at three field strengths ranging from 0.43T and 1.5T. The decrease in susceptibility effects at lower fields that are reflected in longer T 2 and T2* values may be advantageous for optimizing pulse sequences inherently sensitive to such effects. The three-fold increase in T2* at lower field strength would allow lower receiver bandwidths, providing a concomitant decrease in noise and relative increase in SNR. Magn Reson Med 78:1458-1463, 2017. © 2016 International Society for Magnetic Resonance in Medicine., (© 2016 International Society for Magnetic Resonance in Medicine.)

Published
2017
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27. Rapid acquisition of helium-3 and proton three-dimensional image sets of the human lung in a single breath-hold using compressed sensing.

Author

Qing K, Altes TA, Tustison NJ, Feng X, Chen X, Mata JF, Miller GW, de Lange EE, Tobias WA, Cates GD Jr, Brookeman JR, and Mugler JP 3rd

Subjects
Adult, Cystic Fibrosis, Female, Helium administration & dosage, Helium chemistry, Humans, Male, Young Adult, Breath Holding, Imaging, Three-Dimensional methods, Lung physiology, Magnetic Resonance Imaging methods, Protons
Abstract

Purpose: To develop and validate a method for acquiring helium-3 ((3) He) and proton ((1) H) three-dimensional (3D) image sets of the human lung with isotropic spatial resolution within a 10-s breath-hold by using compressed sensing (CS) acceleration, and to assess the fidelity of undersampled images compared with fully sampled images., Methods: The undersampling scheme for CS acceleration was optimized and tested using (3) He ventilation data. Rapid 3D acquisition of both (3) He and (1) H data during one breath-hold was then implemented, based on a balanced steady-state free-precession pulse sequence, by random undersampling of k-space with reconstruction by means of minimizing the L1 norm and total variance. CS-reconstruction fidelity was evaluated quantitatively by comparing fully sampled and retrospectively undersampled image sets., Results: Helium-3 and (1) H 3D image sets of the lung with isotropic 3.9-mm resolution were acquired during a single breath-hold in 12 s and 8 s using acceleration factors of 2 and 3, respectively. Comparison of fully sampled and retrospectively undersampled (3) He and (1) H images yielded mean absolute errors <10% and structural similarity indices >0.9., Conclusion: By randomly undersampling k-space and using CS reconstruction, high-quality (3) He and (1) H 3D image sets with isotropic 3.9-mm resolution can be acquired within an 8-s breath-hold., (© 2014 Wiley Periodicals, Inc.)

Published
2015
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28. A short-breath-hold technique for lung pO2 mapping with 3He MRI.

Author

Miller GW, Mugler JP 3rd, Altes TA, Cai J, Mata JF, de Lange EE, Tobias WA, Cates GD, and Brookeman JR

Subjects
Adolescent, Algorithms, Female, Humans, Isotopes, Radiopharmaceuticals, Tissue Distribution, Young Adult, Helium, Image Interpretation, Computer-Assisted methods, Lung metabolism, Magnetic Resonance Imaging methods, Oxygen metabolism, Oxygen Consumption physiology, Respiratory Mechanics
Abstract

A pulse-sequence strategy was developed for generating regional maps of alveolar oxygen partial pressure (pO2) in a single 6-sec breath hold, for use in human subjects with impaired lung function. Like previously described methods, pO2 values are obtained by measuring the oxygen-induced T1 relaxation of inhaled hyperpolarized 3He. Unlike other methods, only two 3He images are acquired: one with reverse-centric and the other with centric phase-encoding order. This phase-encoding arrangement minimizes the effects of regional flip-angle variations, so that an accurate map of instantaneous pO2 can be calculated from two images acquired a few seconds apart. By combining this phase-encoding strategy with variable flip angles, the vast majority of the hyperpolarized magnetization goes directly into the T1 measurement, minimizing noise in the resulting pO2 map. The short-breath-hold pulse sequence was tested in phantoms containing known O2 concentrations. The mean difference between measured and prepared pO2 values was 1 mm Hg. The method was also tested in four healthy volunteers and three lung-transplant patients. Maps of healthy subjects were largely uniform, whereas focal regions of abnormal pO2 were observed in diseased subjects. Mean pO2 values varied with inhaled O2 concentration. Mean pO2 was consistent with normal steady-state values in subjects who inhaled 3He diluted only with room air., (Copyright (c) 2009 Wiley-Liss, Inc.)

Published
2010
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29. Extending the range of diffusion times for regional measurement of the 3He ADC in human lungs.

Author

Wang C, Miller GW, Altes TA, de Lange EE, Cates GD Jr, Mata JF, Brookeman JR, and Mugler JP 3rd

Subjects
Humans, Image Processing, Computer-Assisted, Isotopes, Male, Phantoms, Imaging, Asthma pathology, Diffusion Magnetic Resonance Imaging methods, Helium, Lung anatomy & histology
Abstract

A stimulated-echo-based technique was developed to measure the regional apparent diffusion coefficient (ADC) of hyperpolarized 3He during a single breathhold for diffusion times of 25 ms or greater. Compared to previous methods, a substantially shorter minimum diffusion time was achieved by decoupling diffusion sensitization from image acquisition. A hyperpolarized-gas phantom was used to validate the method, which was then tested in four healthy subjects in whom regional ADC maps were acquired with diffusion times of 50, 200, and 1500 ms and a tag wavelength of 5 or 10 mm. ADC values from healthy subjects were in good agreement with reported literature values and decreased with increasing diffusion time. Mean ADC values were approximately 0.07, 0.03, and 0.015 cm2/s for diffusion times of 50, 200, and 1500 ms, respectively. ADC maps were generally homogeneous, with similar mean values when measured with the same parameters in different subjects., ((c) 2008 Wiley-Liss, Inc.)

Published
2008
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30. Hyperpolarized 3He lung imaging at 0.5 and 1.5 Tesla: a study of susceptibility-induced effects.

Author

Salerno M, Brookeman JR, de Lange EE, and Mugler JP 3rd

Subjects
Echo-Planar Imaging, Helium, Humans, Isotopes, Lung anatomy & histology, Magnetic Resonance Imaging methods
Abstract

Hyperpolarized (3)He MRI of the human lung was performed at 0.54 and 1.5 T using identical software and hardware (except for RF coils) at both field strengths. The T(*) (2) of (3)He gas in the lung was measured, and the effects of magnetic-susceptibility-induced field inhomogeneities on the appearance of interleaved-spiral and interleaved-echo-planar lung images at 1.5 T were compared to those at 0.54 T. Mean T(*) (2) values for (3)He gas in the healthy human lung were 26.8 +/- 1.5 ms and 67.9 +/- 1.3 ms at 1.5 and 0.54 T, respectively. At 0.54 T, interleaved-spiral images showed markedly less blurring due to susceptibility effects compared to images acquired at 1.5 T. At both 0.54 and 1.5 T, interleaved-echo-planar images appeared essentially identical to corresponding GRE images, even though the data-sampling period per echo and echo time were substantially longer for the interleaved-echo-planar images acquired at 0.54 T., (Copyright 2004 Wiley-Liss, Inc.)

Published
2005
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