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Your search keyword '"pancreatic α-cells"' showing total 2 results
Start Over Descriptor "pancreatic α-cells" Publisher wiley
2 results on '"pancreatic α-cells"'

1. Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells

Author

Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attayeb Mohsen, Tomomitsu Iida, Yamato Miura, Akira Sugawara, and Kazuhiko Yanai

Subjects
Histamine H3 receptor, Glucagon secretion, Pancreatic α-cells, αTC1.6 cells, Biology (General), QH301-705.5
Abstract

Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α‐cells and αTC1.6 cells, a mouse pancreatic α‐cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α‐cells.

Published
2015
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2. Role of histamine H 3 receptor in glucagon‐secreting αTC1.6 cells

Author

Tomomitsu Iida, Tadaho Nakamura, Akira Sugawara, Attayeb Mohsen, Fumito Naganuma, Yamato Miura, Takeo Yoshikawa, and Kazuhiko Yanai

Subjects
endocrine system, Pancreatic α-cells, medicine.medical_specialty, QH301-705.5, Histamine H1 receptor, H3KO, histamine H3 receptor-gene knockout, Biology, CNS, central nervous system, Article, General Biochemistry, Genetics and Molecular Biology, Histamine H3 receptor, Histamine receptor, chemistry.chemical_compound, H3R, histamine H3 receptor, Histamine H2 receptor, Internal medicine, medicine, Histamine H4 receptor, Biology (General), VDCCs, voltage-dependent Ca2+ channels, Glucagon secretion, GLP, glucagon-like peptide, αTC1.6 cells, Immepip, Endocrinology, chemistry, KRB, Krebs–Ringer bicarbonate buffer, Glucagon receptor family, hormones, hormone substitutes, and hormone antagonists
Abstract

Highlights • Histamine H3 receptor is expressed in pancreatic α-cells. • Histamine H3 receptor negatively regulates glucagon secretion from αTC1.6 cells. • Immepip, a selective H3 receptor agonist, decreases serum glucagon concentration in rats., Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca2+ concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α-cells.

Published
2014
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