Search

Enantiomeric excess (ee) is an essential indicator of chiral drug purification in the pharmaceutical industry. However, to date the ee determination of unknown concentration enantiomers generally involves two separate techniques for chirality and concentration measurement. Here, a whispering‐gallery mode (WGM) based optofluidic microlaser near exceptional point to achieve the ee determination under unknown concentration with a single technique is proposed. Exceptional point induces the unidirectional WGM lasing, providing the optofluidic microlaser with the novel capability to measure chirality by polarization, in addition to wavelength‐based concentration detection. The dual‐parameters detection of optofluidic microlaser empowers it to achieve ee determination of various unknown enantiomers without additional concentration measurements, a feat that is challenging to accomplish with other methods. Featuring the sensitivity enhancement and miniature structure of the WGM sensors, the obtained chiroptical response of the present approach is ≈30‐fold higher than that of the conventional optical rotation‐based polarimeter, and the reagent consumption is reduced by three orders of magnitude. [ABSTRACT FROM AUTHOR]

Oncogene E6 plays a critical role in the development and progression of esophageal cancer caused by human papillomavirus (HPV) infection. Alpha‐ketoglutarate (AKG) is a key metabolite in the tricarboxylic acid cycle and has been widely used as a dietary and anti‐ageing supplement. In this study, we found that treating esophageal squamous carcinoma cells with a high dose of AKG can induce cell pyroptosis. Furthermore, our research confirms that HPV18 E6 inhibits AKG‐induced pyroptosis of esophageal squamous carcinoma cells by lowering P53 expression. P53 downregulates malate dehydrogenase 1 (MDH1) expression; however, MDH1 downregulates L‐2‐hydroxyglutarate (L‐2HG) expression, which inhibits a rise in reactive oxygen species (ROS) levels—as L‐2HG is responsible for excessive ROS. This study reveals the actuating mechanism behind cell pyroptosis of esophageal squamous carcinoma cells induced by high concentrations of AKG, and we posit the molecular pathway via which the HPV E6 oncoprotein inhibits cell pyroptosis. [ABSTRACT FROM AUTHOR]

In the quest for economic and social prosperity, countries all over the world are constantly engaged in energy consumption to propel development. The utilization of energy emits dangerous greenhouse gases which have adverse impact on human health and the entire ecosystem. Finding the trade‐off that exists between economic growth and environmental protection is essential nowadays. Previous energy efficiency studies in Africa have focused on static efficiency and ignoring dynamic implications of crossover factors in productivity. Those studies in Africa have also failed to capture energy efficiency trends and patterns over time. Therefore, the current study applies the dynamic slack‐based measure (DSBM) in a data envelopment analysis (DEA) framework to assess the dynamic energy efficiency of 25 sampled African economies from 2007 to 2014 by adopting energy stock as carryover factors. Further, the study investigates the inputs, output, and carryover factors inefficiency in the model to identify the potential areas where inefficiencies occurred. The empirical results suggest that these selected African countries are far from being energy efficient (0.519). Therefore, both adjustments and projections on the inputs, output, and carryover variables should be taken into account, to improve efficiency. Finally, useful suggestions for energy efficiency improvement are further discussed based on the empirical results. [ABSTRACT FROM AUTHOR]

Environmental regulation has been recognized as an important way to directly improve environmental performance or indirectly impact environmental performance through increasing environmental innovation. The present paper constructs an energy and carbon emission total factor productivity index using the Malmquist–Luenberger productivity index and data envelopment analysis. The proposed technique is used to measure the environmental performance of 30 Chinese provinces during the period 2010–2015. The energy and carbon emission total factor productivity measure is divided into a pure technical efficiency index and a technical progress index to provide detailed environmental performance information. Then an ordinary least squares model is adopted to analyse the impact of environmental regulation on environmental innovation operation and environmental performance by hypothesis testing. The empirical results show that environmental regulation and environmental innovation have positive direct effects on environmental performance and that market‐based environmental regulation has a positive indirect effect on environmental performance by increasing environmental innovation. [ABSTRACT FROM AUTHOR]