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Background: Pretreatment controlling nutritional status (CONUT) score is a novel index which was used to predict outcomes in cancer patients. We aim to explore the prognostic significance of CONUT score in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). Patients and methods: A total of 662 UTUC patients between 2004 and 2016 were retrospectively analyzed. Patients were categorized into three groups based on CONUT score (Normal: 0‐1; Light: 2‐4; Moderate/severe: 5‐12). Associations of CONUT score with oncological outcomes were analyzed using Logistic and Cox regression analysis. Harrell concordance index was used to assess the predictive accuracy of the multivariate models. Subgroup analyses were conducted according to tumor grade and stage. Results: The median follow‐up duration was 41 months. Multivariate Logistic analysis showed that high CONUT score was independently associated with high‐grade disease, high pT stage, lymphovascular invasion, sessile carcinoma, variant histology, and positive surgical margins (each P < 0.05). Multivariate analysis demonstrated that CONUT score 5‐12 was an independent factor for worse cancer‐specific survival (CSS, hazard ratio [HR]:2.39, 95% confidence interval [CI] 1.55‐3.68, P < 0.0001), disease recurrence‐free‐survival (RFS, HR: 1.80, 95% CI 1.24‐2.60, P = 0.002), and overall survival (OS, HR: 2.26, 95% CI 1.53‐3.34, P < 0.0001). The estimated c‐index of the multivariate models for CSS, RFS, and OS increased from 0.755, 0.715 and 0.745 to 0.772, 0.723, and 0.756 when CONUT score supplemented. Subgroup analyses showed that especially in patients with high‐grade carcinoma and advanced stage (≥pT3), higher CONUT score predicts decreased CSS, RFS, and OS (all P < 0.05). Conclusion: Preoperative CONUT score is a negative independent prognostic indicator for both pathologic and survival outcomes in UTUC, especially in those with high‐grade carcinoma and advanced stage. Adding this parameter into our clinical prediction model is appropriate so as to improve its predictive accuracy. CONUT score independently predicted worse survival in UTUC patients, especially in patients with high‐grade disease and advanced stage. The addition of CONUT score would improve the predictive accuracy of the multivariate models for survival outcomes. We therefore suggest adding the CONUT score to the traditional predictive model and to the risk stratifications of patients with UTUC. [ABSTRACT FROM AUTHOR]

Purposes: To investigate the value of prognostic nutritional index (PNI) in patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy (RNU). Patients and methods: A total of 717 patients were included in our study from 2003 to 2016. PNI was calculated as 10 × serum albumin level (g/dL) + 0.005 × total lymphocyte count (per mm3). Kaplan‐Meier analysis and Cox regression models were adapted to analyze the value of PNI on survival outcomes. Results: The cutoff value of PNI was set as 46.91 and 298 patients (47.6%) had PNI <46.91. The median follow‐up was 50 months. The results suggested that low PNI was significantly associated with worse pathologic features (all P < 0.001). Multivariable Cox regression analysis revealed that PNI < 46.91 was an independent predictor of poor overall survival (Hazard ratios [HR] = 1.777, 95% CI = 1.383‐2.284, P < 0.001), cancer‐specific survival (HR = 1.850, 95% CI = 1.399‐2.445, P < 0.001), and recurrence‐free survival (HR = 1.554, 95% CI = 1.229‐1.964, P < 0.001). Conclusions: Low preoperative PNI was associated with worse survival outcomes in patients with UTUC. PNI could be an easily assessed blood‐based biomarker to predict the prognosis in patients with UTUC treated with RNU. [ABSTRACT FROM AUTHOR]