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2. Vaccines as Monotherapy and in Combination Therapy for Prostate Cancer.

Author

Rotow, Julia, Gameiro, Sofia R., Madan, Ravi A., Gulley, James L., Schlom, Jeffrey, and Hodge, James W.

Subjects
PROSTATE cancer, CANCER vaccines, DRUG therapy, PREVENTIVE medicine
Abstract

Prostate cancer is the second leading cause of cancer death among men in the United States. Standard-of-care chemotherapy for metastatic castration-resistant prostate cancer is associated with significant but modest survival benefit, indicating a need for alternative and/or additional approaches. The use of therapeutic cancer vaccines for the treatment of prostate cancer represents a novel targeted therapeutic approach. Whereas vaccine strategies are being developed for the treatment of various stages of prostate cancer, this article focuses on novel vaccine strategies for castration-resistant prostate cancer that have been translated into late-stage clinical studies. [ABSTRACT FROM AUTHOR]

Published
2010
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