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This study proposes a novel protection scheme for residual current devices (RCDs) based on the theory of skewness and the least squares‐support vector machine (LS‐SVM). The skewness of the residual current is applied to detect the electric shock fault time, and the LS‐SVM regression technique is used to perform touch current identification. The experimental test results indicate that the protection scheme can not only detect the electric shock fault time correctly and rapidly but also effectively recognise the circulation through the animal's current. Moreover, the proposed protection technique can provide valuable information for developing new generations of RCDs. [ABSTRACT FROM AUTHOR]

The aberrant accumulation of β-amyloid peptide (Aβ) in the brain is a key feature of Alzheimer's disease ( AD), and enhanced cleavage of β-amyloid precursor protein ( APP) by β-site APP-cleaving enzyme 1 ( BACE1) has a major causative role in AD. Despite their prominence in AD pathogenesis, the regulation of BACE1 and APP is incompletely understood. In this study, we report that the circular RNA circular RNA sponge for miR-7 (ciRS-7) has an important role in regulating BACE1 and APP protein levels. Previous studies have shown that ci RS-7, which is highly expressed in the human brain, is down-regulated in the brain of people with AD but the relevance of this finding was not clear. We have found that ci RS-7 is not involved in the regulation of APP and BACE1 gene expression, but instead reduces the protein levels of APP and BACE1 by promoting their degradation via the proteasome and lysosome. Consequently, overexpression of ci RS-7 reduces the generation of Aβ, indicating a potential neuroprotective role of ci RS-7. Our data also suggest that ci RS-7 modulates APP and BACE1 levels in a nuclear factor-κB (NF-κB)-dependent manner: ci RS-7 expression inhibits translation of NF-κB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation. Additionally, we demonstrated that APP reduces the level of ci RS-7, revealing a mutual regulation of ci RS-7 and APP. Taken together, our data provide a molecular mechanism implicating reduced ci RS-7 expression in AD, suggesting that ci RS-7 may represent a useful target in the development of therapeutic strategies for AD. [ABSTRACT FROM AUTHOR]