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Background: After the low quality of Chinese clinical practice guidelines (CPGs) for respiratory diseases published from 1979 to 2013 was reported, some handbooks were published to standardize guidelines' development recently. There was a great increase in the production and dissemination of CPGs annually in China, whose quality and potential impact were unknown. Methods: A systematic search of four literature databases was performed for the period January 2013 to December 2018 to identify Chinese CPGs for respiratory diseases. Eligible CPGs were evaluated using the appraisal of guidelines for research and evaluation II (AGREE II) instrument. Results: A total of 197 CPGs were identified for review. Compared with the result of previous study, the increased scores of the six AGREE II domains were screened: Scope and purpose (57.3% vs. 57.8%), Stakeholder involvement (17.6% vs. 25.0%), Rigor of development (10.2% vs. 13.2%), Clarity and presentation (55.2% vs. 58.4%), Applicability (9.3% vs. 25.9%), and Editorial independence (1.1% vs. 6.3%). The improved overall assessment for included CPGs were: Recommended (4, 2.0% vs. 0, 0%) and Recommended with modifications (26, 13.2% vs. 3, 2.8%). The improved level of evidence used to make recommendations were 59, 11.9% versus 168, 22.4% and 88, 17.7% versus 195, 26.0%, A and B, respectively. Conclusions: The overall quality of CPGs for respiratory diseases published from 2013 to 2018 in China was slightly improved, but had a big gap with the optimum level, especially in Rigor of development and Editorial independence. Increased efforts are required to enable the development of high‐quality evidence‐based CPGs for respiratory diseases. [ABSTRACT FROM AUTHOR]

In the present day, when centralized energy storage technology is becoming increasingly mature, the cooperative energy sharing framework between the combined cooling, heating, and power (CCHP) systems and a shared energy storage provider (SESP) can effectively promote the local consumption of renewable energy and reduce the social energy cost. In this study, the optimal operation models of CCHP and SESP are first developed by considering the electric energy trading of the CCHP and the SESP. Then the CCHP–SESP cooperative operation model is established based on Nash bargaining theory, followed by equating it into two subproblems of coalition social energy cost minimization and electric energy trading payment negotiation. The alternating direction method of multipliers approach is introduced to solve the energy‐sharing problems in a distributed way. Numerical simulation results show the effectiveness of the proposed energy‐sharing framework. Simulation results show that the proposed bargaining‐based energy‐sharing framework can significantly reduce the social energy cost and improve the utilization rate of energy storage resources. [ABSTRACT FROM AUTHOR]

We fitted 75 pulses from 44 gamma‐ray burst (GRB) prompt emission lightcurves, including four short ones and 40 long ones. Each pulse is fitted by a fast‐rising exponential‐decay (FRED) model. The statistical properties of these pulses are analyzed and compared with previous works. We found that the FRED model is almost suitable to describe all the pulses. We reconfirmed that there is a linear correlation between the full width at half maximum FWHM$$ \mathrm{FWHM} $$ and the pulse rising time Trise$$ {T}_{\mathrm{rise}} $$, which supports the idea that the individual pulse is emitted at once within one explosion. Moreover, we found that several pulses do not obey the FWHM−Trise$$ \mathrm{FWHM}-{T}_{\mathrm{rise}} $$ correlation, this implies that the radiation process of the prompt emission especially in the multi‐pulse GRBs might involve more than one type and even possibly change with time. The innovation of this work lies in examining the statistical characteristics of lightcurves of both long and short‐duration GRBs and re‐evaluating the applicability of empirical relationships discovered by predecessors to both types of GRBs while paying special attention to the existence of outlier pulses. This work has positive implications for further exploring the diversity of GRB prompt radiation mechanisms. [ABSTRACT FROM AUTHOR]

Abstract: The hepatocyte growth factor (HGF) receptor, Met, is frequently overexpressed in nasopharyngeal cancer (NPC). Here, we showed for the first time that human NPC cells with high Met expression were more sensitive to the cell motility and invasion effect of HGF. The downregulation of Met by small interfering RNA decreased tumor cell invasion/migration. HGF significantly increased matrix metalloproteinase-9 production. This was inhibited by blocking phosphatidylinositide 3-kinase (PI3K) and c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling pathways. We also demonstrated that PI3K induced activation of JNK, with Akt as a potential point of this cross-talk. These results provide new insights into the molecular mechanism responsible for NPC progression and metastasis. [Copyright &y& Elsevier]