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Arsenic trioxide suppresses acute graft-versus-host disease by activating the Nrf2/HO-1 pathway in mice To further confirm that ATO alleviates GVHD symptoms mainly through activating the Nrf2/HO-1 pathway, we established the GVHD+PBS+ATO and GVHD+ML835+ATO groups. The GVHD+ML835+ATO mice showed shorter survival (Fig C) and increased levels of GVHD, as shown by the skin defects (Fig D) than the GVHD+PBS+ATO group. The peripheral blood CD4+ T/CD8+ T ratio (Fig F) and serum concentration of TNF-a and IFN- (Fig G), which were reduced by ATO, were also decreased in the GVHD+ ML835+ATO group. [Extracted from the article]