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In this paper we describe the first in vitro response to the liver alloantigen F. The anti-F response serves as a valuable model for autoimmune phenomena since priming appropriate strains of mice (responders) with allogeneic but not syngeneic type F leads to autoantibody production. The in vitro system is based on the proliferation of T cells, from mice primed in vivo with F, when coincubated with splenic adherent cells (SAC) prepulsed with F in vivo. The system displays two important correlates of the in vivo antibody response to F:1.T cells from mice primed with syngeneic F do not proliferate when incubated with SAC prepulsed with syngeneic F and 2. Mice that do not make antibody responses to allo F in vivo (DBA/2) do not show in vitro proliferative responses. These findings indicate that the proliferative assay is a good in vitro model for the F response. [ABSTRACT FROM AUTHOR]

The article presents abstracts of research papers about myelin genes and autoimmunity. They include "A role for myelin and nonmyelin autoantibodies in the pathogenesis of demyelinating disease," "Autoimmune T cell response to myelin antigens: building better animal models for MS," "Tolerance induction of MBP-specific T cells," and "Golli protein negatively regulates store-depletion-induced calcium influx in T cells."