1. Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease.
- Author
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Zinellu, Angelo, Fois, Alessandro Giuseppe, Sotgia, Salvatore, Zinellu, Elisabetta, Bifulco, Fabiana, Pintus, Gianfranco, Mangoni, Arduino A., Carru, Ciriaco, and Pirina, Pietro
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OBSTRUCTIVE lung diseases , *ASTHMA , *LUNG diseases , *OXIDATIVE stress , *LOGISTIC regression analysis , *BRONCHIAL diseases , *RESPIRATORY allergy - Abstract
Chronic obstructive pulmonary disease ( COPD) and asthma are both characterized by heterogeneous chronic airway inflammation and obstruction as well as oxidative stress ( OS). However, it is unknown whether OS occurs in early disease and how to best assess its presence. Plasma OS markers ( TBARS, PSH, taurine, GSH, ergothioneine and paraoxonase 1 activity) and lung function tests were measured in patients with mild stable asthma ( n = 24) and mild stable COPD ( n = 29) and in age- and sex-matched controls. Forced expiratory volume in 1 s ( FEV1) was associated with age both in patients and control groups. By contrast, FEV1 was positively correlated with PSH only in COPD (ρ = 0·49, P = 0·007). In multiple logistic regression analysis, lower PSH was the only OS marker independently associated with increased odds of both asthma ( OR = 0·32, 95% CI 0·13-0·78, P = 0·01) and COPD ( OR = 0·50, 95% CI 0·26-0·95, P = 0·03). These findings suggest that proteins -SH are a sensitive OS marker in early COPD and asthma. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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