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The asymmetric synthesis of dragmacidin D ( 1) was completed in 10 steps. Its sole stereocenter was set by using direct asymmetric alkylation enabled by a C2-symmetric tetramine and lithium N-(trimethylsilyl)- tert-butylamide as the enolization reagent. A central Larock indole synthesis was employed in a convergent assembly of the heterocyclic subunits. The stereochemical evidence from this work strongly supports the predicted S configuration at the 6′′′ position, which is consistent with other members of the dragmacidin family of natural products. [ABSTRACT FROM AUTHOR]

An abstract of the study "Synthesis of 2-Aminoazoles from Thioesters via α-Heterosubstituted Ketones by Copper-Mediated Cross-Coupling" by H. Kobayashi and colleagues is presented.

An abstract of the article "10-step asymmetric total synthesis and stereochemical elucidation of (+)-dragmacidin D," by J.J. Jackson and colleagues is presented.