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Despite widespread use of the deuterium isotope effect, selective deuterium labeling of chemical molecules remains a major challenge. Herein, a facile and general electrochemically driven, organic mediator enabled deuteration of styrenes with deuterium oxide (D2O) as the economical deuterium source was reported. Importantly, this transformation could be suitable for various electron rich styrenes mediated by triphenylphosphine (TPP). The reaction proceeded under mild conditions without transition‐metal catalysts, affording the desired products in good yields with excellent D‐incorporation (D‐inc, up to >99 %). Mechanistic investigations by means of isotope labeling experiments and cyclic voltammetry tests provided sufficient support for this transformation. Notably, this method proved to be a powerful tool for late‐stage deuteration of biorelevant compounds. [ABSTRACT FROM AUTHOR]

Herein, an electrochemically driven NiH‐catalyzed reductive coupling of alkyl halides and alkyl alkenes for the construction of Csp3−Csp3 bonds is firstly reported. Notably, alkyl halides serve dual function as coupling substrates and as hydrogen sources to generate NiH species under electrochemical conditions. The tunable nature of this reaction is realized by introducing an intramolecular coordinating group to the substrate, where the product can be easily adjusted to give the desired branched products. The method proceeds under mild conditions, exhibits a broad substrate scope, and affords moderate to excellent yields with over 70 examples, including late‐stage modification of natural products and drug derivatives. Mechanistic insights offer evidence for an electrochemically driven coupling process. The sp3‐carbon‐halogen bonds can be activated through single electron transfer (SET) by the nickel catalyst in its low valence state, generated by cathodic reduction, and the generation of NiH species from alkyl halides is pivotal to this transformation. [ABSTRACT FROM AUTHOR]

Carbon dioxide (CO2) is an abundant, inexpensive, renewable C1 resource and the main component of greenhouse gas, thereby the research for its sustainable and efficient conversion has received notable attention in recent years. Electrochemical organic synthesis, as a green and efficient synthetic method, is convinced to be an ideal approach for CO2 utilization. In this review, recent advances in electrocarboxylation with CO2 were summarized through different reaction types, which would disclose the great potential of electrocarboxylation in green organic synthesis. [ABSTRACT FROM AUTHOR]

Carbon dioxide (CO2) is an abundant, inexpensive, renewable C1 resource and the main component of greenhouse gas, thereby the research for its sustainable and efficient conversion has received notable attention in recent years. Electrochemical organic synthesis, as a green and efficient synthetic method, is convinced to be an ideal approach for CO2 utilization. In this review, recent advances in electrocarboxylation with CO2 were summarized through different reaction types, which would disclose the great potential of electrocarboxylation in green organic synthesis. [ABSTRACT FROM AUTHOR]