1. Meta‐analysis of associations between <italic>XRCC1</italic> gene polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis.
- Author
-
Zhang, Ming‐yue, Yang, Xiao‐ke, Lv, Tian‐tian, Wu, Jun, Xu, Shu‐zhen, Wang, Jie‐bing, Pan, Hai‐feng, and Ye, Dong‐qing
- Subjects
META-analysis ,GENETIC polymorphisms ,SYSTEMIC lupus erythematosus ,RHEUMATOID arthritis ,TRP channels ,CAUCASIAN race - Abstract
Abstract: Objective: To determine whether X‐ray repair cross‐complementing group 1 (
XRCC1 ) gene polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A meta‐analysis was conducted to determine the associations betweenXRCC1 gene polymorphisms and susceptibility to SLE and RA. Methods: A systematic literature search was conducted to identify all relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Results: A total of nine case‐control articles, consisting of five SLE and four RA articles, involving 1138 patients and 1399 healthy controls, were included in the meta‐analysis. This meta‐analysis showed no significant association of the Arg399Gln and Arg194Trp polymorphisms with SLE were found in all models when all study subjects were considered together. Stratification by ethnicity indicated the variant Arg399 (A) allele carriers increased the risk of SLE in Asians (Avs . G: OR = 1.402, 95% CI = 1.139–1.726,P = 0.001) and decreased the risk of SLE in Caucasians (Avs . G: OR = 0.769, 95% CI = 0.630–0.937,P = 0.009; AAvs . AG+GG: OR = 0.727, 95% CI = 0.554–0.953,P = 0.021). However, we failed to reveal any association betweenXRCC1 gene polymorphisms (Arg399Gln, Arg280His and Arg194Trp) and RA risk under all analysis models. Similar results were obtained in the subgroup analysis based on ethnicity. Conclusions: The present study suggests that theXRCC1 Arg399Gln polymorphism might be associated with genetic susceptibility to SLE in Asians and Caucasians, and there is no significant association betweenXRCC1 gene polymorphisms (Arg399Gln, Arg280His and Arg194Trp) and RA risk. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF