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Introduction: Adult acute myeloid leukaemia (AML) patients with complex karyotype (CK) generally have unfavourable outcomes. CK commonly co‐exists with characteristic chromosomal and genetic abnormalities such as monosomal karyotype (MK), −17 or 17p‐ [abn(17p)] and TP53 mutations. Their individual prognostic significance needs to be clarified. Methods: Seventy‐three adult CK‐AML patients and eleven adult non‐CK‐AML patients with TP53 mutations (non‐CK/TP53mu) who were diagnosed and received therapy at our institute were enrolled. One hundred and fifty‐seven AML cases retrieved from the cancer genome atlas (TCGA) for validation. Results: Among CK‐AML patients, those with TP53 mutations (CK/TP53mu) had significantly lower rates of 1‐course induction complete remission (CR), 2‐year relapse‐free survival (RFS) and 2‐year overall survival (OS) than those without TP53 mutations (CK/TP53wt); whereas, abn(17p) did not have the above impacts; MK was significantly associated with a lower 2‐year OS rate but was not related to the rates of CR and RFS. Multivariate analysis showed that it were TP53 mutations and treating with chemotherapy alone but not MK and abn(17p) that independently predicted the adverse prognosis for RFS and OS in CK‐AML. Furthermore, non‐CK/TP53mu patients showed similar rates of CR, RFS and OS to CK/TP53mu patients. Validation using the TCGA cohort showed that CK/TP53mu patients had a significantly lower 2‐year OS rate than CK/TP53wt patients, whereas abn(17p) and MK did not impact OS; the 2‐year OS rate of patients with CK/TP53wt was similar to that of patients with intermediate‐risk cytogenetics. Conclusion: Adult CK‐AML patients have varied risks and TP53 mutations seem to be an independent adverse prognostic factor. [ABSTRACT FROM AUTHOR]

Understanding the changes in microbial community composition in wetlands affected by different types of degradation can help enrich theoretical knowledge about wetland degradation. However, studies of the relative role of microorganisms under different types of degradation of wetlands are rare in wetland ecology. Because of agricultural development, a large volume of groundwater has been extracted from the Sanjiang Plain over the last few decades, which has caused wetland degradation. To provide information for the development and protection of this wetland ecosystem, investigations into the processes of wetland degradation are important. The aim of the present work was to assess the impacts of wetland degradation on soil microbial communities under four different types of wetlands degradation in the Sanjiang Plain: swamp meadow (SW), meadow wetland (MW), paddy farmland (PF), and cropland (CL). Both 16S and ITS rRNA gene amplicon sequencing were used to evaluate the diversity and composition of bacteria and fungi. A total of 638,758 effective 16S rRNA and 916,211 valid internal transcribed spacer rRNA gene sequences were obtained, which were classified into 11 fungal and 40 bacterial phyla. The dominant fungal and bacterial phyla were Ascomycota and Proteobacteria, respectively. In addition, wetland degradation increased the relative abundances of Chloroflexi and Gemmatimonadetes, but the relative abundances of Proteobacteria and Verrucomicrobia significantly decreased. The bacterial Shannon index of SW was lower than those of the other investigated sites. Fungal diversity showed no significant differences for different types of degraded wetlands. In addition to wetland degradation, different reactions of the dominant microbial phyla and their diversity were clearly coorelated with total phosphorus (TP), total potassium (TK), available potassium (AK), and soil organic matter (SOM), which formed essential criteria that influenced the soil microbial communities. Wetland degradation resulted in the decrease of soil nutrient and the decline of the abundance of dominant phylum in soil bacterial and fungal communities. These changes can be used as an early warning signal for the degrading wetland of the Sanjiang Plain. [ABSTRACT FROM AUTHOR]

Mesozoic magmatism and lithospheric destruction in East China exerted significant control on gold metallogeny. Here, we investigate the mineralogy, geochemistry, geochronology, and isotopic systematics of the Dongyang gold deposit in southeast China to constrain its origin and geodynamics. This is a newly discovered epithermal gold deposit along the Circum–Pacific metallogenic belt and is characterized by intense silicification and sericitization. The C–H–O isotope data suggest deep magmatic sources of the ores and indicate that the ore‐forming fluids comprised a mixture of magmatic water and meteoric water. The S–Pb values of the pyrite indicate magmatic origin for the sulfur, and deposit was derived mostly from crustal sources, mixed with mantle materials. The Rb–Sr dating of the pyrite from the ore deposit shows an age of 164.2 ± 9.9 Ma, whereas the zircon U–Pb SHRIMP ages of the rhyolite porphyry is 160.9 ± 0.5 Ma, suggesting that the timing of mineralization is close to that of the crystallization of the dykes. In conjunction with previous studies on similar deposits, we suggest that the gold mineralization was the response of continental lithospheric thinning in southeast China triggered by the subduction of the Palaeo‐Pacific Ocean Plate. [ABSTRACT FROM AUTHOR]