1. Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum.
- Author
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Chadie, A., Radi, S., Trestard, L., Charollais, A., Eurin, D., Verspyck, E., and Marret, S.
- Subjects
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NEURODEVELOPMENTAL treatment , *CHILDREN , *PRENATAL diagnosis , *CORPUS callosum , *BRAIN imaging , *CYSTS (Pathology) , *MAGNETIC resonance imaging , *BRAIN abnormalities - Abstract
Aim: To evaluate long-term neurodevelopmental outcomes in children with prenatally diagnosed, isolated agenesis of the corpus callosum (ACC). Methods: We retrospectively reviewed data for 20 children born between January 1991 and November 2003 in the Haute-Normandie region of France with a prenatal diagnosis of isolated ACC. We collected data on pre-and postnatal neuroimaging findings, clinical features at birth and neurodevelopmental outcomes. Results: Follow-up ranged from 3 to 16 years. ACC was complete in 11 patients (55%), partial in 2 (10%), hypoplastic in 3 (15%) and associated with an interhemispheric cyst in 4 (20%). Neurodevelopmental outcome was normal in 11 (55%) patients, including 8 with complete ACC; moderate disability was present in 5 (25%) patients and severe disability in 4 (20%) patients. In 3 of the 4 patients with severe disability, postnatal cerebral magnetic resonance imaging (MRI) showed additional major cerebral abnormalities. Conclusion: Neurodevelopmental outcome was good in most of our patients with isolated ACC, with 80% of patients having normal outcomes or moderate disabilities. A prenatal diagnosis of isolated ACC may not warrant termination of pregnancy. A carefully interpreted prenatal cerebral MRI is crucial to detect associated cerebral abnormalities; a longer follow-up is necessary to look for moderate disabilities. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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