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Background The Patient Journey Record system ( Pa JR) is an application of a complex adaptive chronic care model in which early detection of adverse changes in patient biopsychosocial trajectories prompts tailored care, constitute the cornerstone of the model. Aims To evaluate the Pa JR system's impact on care and the experiences of older people with chronic illness, who were at risk of repeat admissions over 12 months. Design Community-based cohort study - random assignment into intervention and usual care group, with process and outcome evaluation. Study population Adult and older patients with multiple morbidity, one or more chronic diseases with one or more overnight hospitalizations, and seven or more general practice visits in the past 6 months. Complex intervention Pa JR lay care guides/advocates call patients and their caregivers. The care guides summarize their semi-structured conversations about health concerns and well-being. Predictive modelling and rules-based algorithms trigger alerts in relation to online call summaries. Alerts are acted upon according to agreed guidelines. Analysis Descriptive and comparative statistics. Outcomes Impact on unplanned emergency ambulatory care sensitive admissions ( ACSC) with an overnight stay; sensitivity of alerts and predictions; rates of care guides-supported activities. Findings Five part-time lay care guides and a care manager monitored 153 intervention patients for 500 person months with 5050 phone calls. The 153 patients in the intervention group were comparable to the 61 controls. The intervention group reported in 50% of calls that their health limited their social activities; and one-third of calls reported immediate health concerns. Predictive analytics were highly sensitive to risk of hospitalization. ACSC admissions were reduced by 50% compared to controls across the sites. Discussion The initial implementation of a complex patient-centred adaptive chronic care model using lay care guides, supported by machine learning, appeared sensitive to risk of hospitalization and capable of stabilizing illness journeys in older patients with multi-morbidity. Conclusion Actions based on alerts produced in this study appeared to significantly reduce hospitalizations. This paves the way for further testing of the model. [ABSTRACT FROM AUTHOR]