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Gastric cancer represents a diffuse and aggressive neoplasm, whose mortality index is among the highest in the world. Predisposing factors are E-cadherin mutations, Helicobacter pylori infection, and a diet rich in salted and smoked food, with a low intake of fresh fruits and vegetables. Here, we analyzed the effect of total lipophilic extracts of two Southern Italy tomato varieties, San Marzano and Corbarino, on an in vitro model of gastric cancer, YCC-1, YCC-2 and YCC-3 cell lines, characterized by different aggressiveness. Our results showed a possible role of these two varieties of tomatoes against typical neoplastic features. The treatment with tomato extracts affected cancer cell ability to grow both in adherence and in semisolid medium, reducing also cell migration ability. No toxic effects were observed on non-tumoral cells. We found, on gastric cancer cell lines, effects on both cell cycle progression and apoptosis modulation. The extent of antineoplastic effects, however, did not seem to correlate with the carotenoid content and antioxidant activity of the two tomato varieties. Our data indicate that San Marzano and Corbarino intake might be further considered as nutritional support not only in cancer prevention, but also for cancer patient diet. [ABSTRACT FROM AUTHOR]

The enzyme-mediated synthesis of enantiomerically enriched 1,3-dioxane odorants analogous to Floropal® is here described. The complete olfactory evaluation of each sample is also reported. The addition of a single methyl group at C5 of the dioxane ring of Floropal® modifies the elicited odour sensation, still preserving a pleasant character. The substitution of the methyl group at C6 with just an ethyl moiety completely changes the odour profile of the molecule. Even subtler are the odour differences generated by configurational variations. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The enzyme-mediated synthesis of enantiomerically enriched 1,3-dioxane odorants analogous to Floropal® is here described. The complete olfactory evaluation of each sample is also reported. The addition of a single methyl group at C5 of the dioxane ring of Floropal® modifies the elicited odour sensation, still preserving a pleasant character. The substitution of the methyl group at C6 with just an ethyl moiety completely changes the odour profile of the molecule. Even subtler are the odour differences generated by configurational variations. Copyright © 2004 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]