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Summary: Statistical validation of spatial predictions of soil properties requires assessment of errors against measured values. The objective of this study was to assess the size of errors in the measurement of soil pH from different sources in the United States of America national databases and implications of the size of errors for prediction, validation and management decision making under uncertain conditions. Error sources included measurement methods, laboratory conditions, pedotransfer functions, database manipulations, location accuracy, and spatial and polygon methods of interpolation. The databases consisted of measured soil pH values from the US National Cooperative Soil Survey Characterization Database (NCSS–SCDB) and estimated values from US Soil Survey Geographic (SSURGO) and State Soil Geographic (STATSGO2) databases. The degree of agreement between measurement methods ranged from poor to substantial, with Lin's concordance correlation coefficients (ρc) varying from 0.83 (pH 1:1W against 1:5CaCl2) to 0.95 (pH 1:1W against pH 1:5W) and root mean square error (RMSE) varying from 0.27 to 0.43. The degree of agreement between pH 1:1W, 1:2CaCl2 and mid‐infrared spectroscopy (MIR) ranged from poor to moderate. The RMSE for MIR was 0.40 for pH 1:1W and 0.32 for soil pH 1:2CaCl2. The RMSE for between‐laboratory reproducibility varied from 0.50 (pH 1:1W) to 0.68 (pH 1:2CaCl2) and was greater than within‐laboratory reproducibility (pH 1:1W, 0.34; pH 1:2 CaCl2, 0.22) and repeatability (pH 1:1W, 0.19; pH 1:2CaCl2, 0.04). The RMSE for the relations for profile depth slicing (weighted mean against equal‐area spline) was 0.36. The RMSE for the relation between soil pH 1:1W for the Global Positioning System and Public Land Survey System was 0.57. Predictions based on polygon or spatial interpolation had the largest RMSEs, 0.78 and 0.62, respectively. Soil liming recommendations based on 0.1 pH increments do not reflect error measurements or the uncertainty of spatial prediction. Although it was not possible to establish consistent trends in the size of error (progressively increasing from measurement to aggregation), its assessment can improve modelling and management at various scales. Highlights: We assessed sources of errors and uncertainty for measured and spatial predictions of soil pH.The smallest error was reported for measured pH (0.06).Polygon or spatial interpolation resulted in the largest error (0.68).Differences in error size influenced rates of liming and cost. [ABSTRACT FROM AUTHOR]

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Controlled-environment studies were conducted on two Brassica crops (canola, Brassica napus; and Shanghai pak choi, B. rapa subsp. chinensis var. communis) to examine the effects of temperature on infection and subsequent development of clubroot caused by Plasmodiophora brassicae. In the first experiment, canola seedlings were grown in infested soil for 3 weeks at 14-26°C to assess the impact on primary and secondary infection and transferred to 20°C for 3 weeks to assess symptom development under uniform conditions, or started at 20°C for 3 weeks and then placed at the treatment temperatures for the final 3 weeks to assess the impact of temperature on symptom development. A second experiment examined a wider range of temperatures (10-30°C). Similar experiments were also conducted on Shanghai pak choi. The studies demonstrated that clubroot severity was affected by temperature during both infection and vegetative development of the crop. Both early and late in crop development, little or no clubroot developed at temperatures at or below 17°C, and development was slower above 26°C than at 23-26°C for both crops throughout the study. In canola, the high levels of inoculum used in the study resulted in a high incidence of clubroot irrespective of temperature, but in pak choi incidence showed the same pattern as severity. This is the first study to demonstrate under controlled conditions that temperature during vegetative growth of the crop affects symptom development of clubroot. [ABSTRACT FROM AUTHOR]

Clubroot caused by Plasmodiophora brassicae is an emerging threat to canola ( Brassica napus) production in western Canada, and a serious disease on crucifer vegetable crops in eastern Canada. In this study, seven biological control agents and two fungicides were evaluated as soil drenches or seed treatments for control of clubroot. Under growth cabinet conditions, a soil-drench application of formulated biocontrol agents Bacillus subtilis and Gliocladium catenulatum reduced clubroot severity by more than 80% relative to pathogen-inoculated controls on a highly susceptible canola cultivar. This efficacy was similar to that of the fungicides fluazinam and cyazofamid. Under high disease pressure in greenhouse conditions, the biocontrol agents were less effective than the fungicides. Additionally, all of the treatments delivered as a seed coating were less effective than the soil drench. In field trials conducted in 2009, different treatments consisting of a commercial formulation of B. subtilis, G. catenulatum, fluazinam or cyazofamid were applied as an in-furrow drench at 500 L ha water volume to one susceptible and one resistant cultivar at two sites seeded to canola in Alberta and one site of Chinese cabbage in Ontario. There was no substantial impact on the susceptible canola cultivar, but all of the treatments reduced clubroot on the susceptible cultivar of Chinese cabbage, lowering disease severity by 54-84%. There was a period of 4 weeks without rain after the canola was seeded, which likely contributed to the low treatment efficacy on canola. Under growth cabinet conditions, fluazinam and B. subtilis products became substantially less effective after 2 weeks in a dry soil, but cyazofamid retained its efficacy for at least 4 weeks. [ABSTRACT FROM AUTHOR]

We review the evidence on computer-aided detection (CAD) as an adjunct to mammography interpretation, and discuss the complexity of its impact on decision-making and potential medico-legal aspects. CAD prompts the reader to review lesions on the mammogram and re-evaluate the decision on whether to recall CAD-prompted findings. Studies show that CAD can improve the sensitivity of a single reader, with an incremental cancer detection rate (from adding CAD to a single read) ranging between 1 and 19%. However, CAD will also substantially increase the recall rate (decrease the reader's specificity) causing additional recall in approximately 6-35% of women. Evidence indicates that CAD does not perform as well as double (human) reading in the context of organized breast screening where double reading is the standard of care. Although CAD can identify and prompt readers to missed cancers, the high number of false-positive prompts (1.5-4 false prompts per case) can have an adverse effect on clinical decision-making, and detracts from CAD's application in screening practice. Refinement in CAD algorithms, in combination with increasing implementation of digital mammography, may improve the potential use of CAD in mammography reading, but will require prospective evaluation. [ABSTRACT FROM AUTHOR]

The effect of precooking by extrusion processing on the dietary fiber profile of wheat flour substituted with 0%, 10%, 20%, and 30% wheat bran was evaluated. Depending on the level of bran, total dietary fiber (TDF) and soluble dietary fiber (SDF) in uncooked flours ranged from 4.2% to 17.2% and 1.5% to 2.4%, respectively. Precooking by extrusion significantly increased SDF in flours (by 22% to 73%); although in most cases it also led to a significant decrease in TDF. Cookies and tortillas produced from uncooked and precooked flours with 0% and 20% substituted bran were evaluated for consumer acceptability using a 9-point hedonic scale. With a few exceptions, all cookies had scores ranging from 6 to 7 (“like slightly” to “like moderately”) for each attribute, including overall acceptability, appearance, texture, crumbliness, and flavor. Tortillas were rated for the same attributes except for crumbliness, which was replaced with chewiness. In most cases, tortilla scores ranged from 5 to 7 (“neither like nor dislike” to “like moderately”). Consumer acceptability scores of cookies from uncooked flour did not change significantly with increase in bran substitution from 0% to 20%. However, consumer scores for tortillas did decrease significantly with increase in bran level. Extrusion precooking of the flours did not improve the consumer acceptability of cookies and tortillas; however, it did improve their dietary fiber profile by increasing the SDF significantly. [ABSTRACT FROM AUTHOR]

Maize (Zea mays L.) is the most important cereal crop in the hills of Nepal, where the grain is used for human consumption and the stover for animal fodder. Maize farms are small, and population pressure necessitates the intensification of existing farming systems. Maize research directed at developing technologies for maize production began in Nepal in 1965. In 2000, a survey was carried out in two districts to determine the current level of adoption of improved maize production practices. In each of these districts, remote and accessible village development committees (VDCs) were surveyed. Questionnaires were administered to 54 randomly selected households in each VDC. A Tobit analysis was used to determine socio-economic, physical and technology factors that influence the use of improved varieties by farmers. All households use composted farmyard manure, and in the more accessible areas, urea as part of their soil fertility management strategy. Use of improved varieties was less than 60% for all VDCs and only 15% in the most remote VDC. In three of the four VDCs, adoption of improved varieties primarily occurred during the past 5 years. Based on a Tobit analysis, Khet land area, ethnic group, years of fertiliser use, off-farm income, and contact with extension significantly and positively affected adoption of improved varieties. Farmers in VDCs in central Nepal reported lack of seed to be the major constraint to the adoption of improved varieties, while lack of knowledge of new varieties was the major constraint for farmers in the western VDCs. The results from this survey suggest that the strategy for improving the adoption of new varieties will differ depending on infrastructure and the socio-economic conditions of the farmers in a given area. [Copyright &y& Elsevier]

BSTRACT: Live cells of Bifidobacterium longum, microencapsulated in K-carrageenan, were added to stirred yogurt after fermentation (pH 4.6) and stored at 4.4 °C for 30 d. Cell enumeration indicated no decline of encapsulated cell number in yogurt samples, while there was significant reduction in nonencapsulated cell population (89.3% for B. longum B6 and 91.8% for B. longum ATCC 15708). Ion-exchange high-performance liquid chromatography showed comparable amounts of lactic and acetic acids in all samples, indicating little metabolic activity by bifidobacteria in experimental yogurts. Consumer sensory analysis of blackberry-flavored yogurts revealed that samples containing encapsulated bifidobacteria had a grainy texture. Results suggested that microencapsulation protected bifidobacteria from the low pH of yogurt. [ABSTRACT FROM AUTHOR]

A bandpass filter (BPF) with a central frequency of 2.31 GHz for future worldwide interoperability for microwave access (WiMax) applications using integrated passive device technology is presented. To realise the BPF, an interdigital capacitor is integrated between the two divisions of a square-shaped spiral inductor. To achieve a compact size, the capacitor is fully embedded inside the inductor. Additionally, the coils of the inductor are intertwined to utilise enhanced mutual inductance for minimising the loss of signal transmission. The strong electromagnetic coupling between the source and load through the interdigital capacitor results in excellent bandpass skirt selectivity with a measured return loss of 26.1 dB. Moreover, it provides an improved stopband response due to the presence of a transmission zero at 5.94 GHz. [ABSTRACT FROM AUTHOR]

We describe a case of mucus plug in the right main bronchus with ipsilateral obstructive emphysema and contralateral opaque hemithorax in an 18-month-old girl who presented with respiratory distress. The role of multi-detector CT scan with multi-planar reconstructions and virtual bronchoscopy is highlighted. [ABSTRACT FROM AUTHOR]

BSTRACT: Eight cooked chuck muscles were subjected to Warner-Bratzler shear (WBS) force analysis in phase I of the study to choose the cooking methods and temperature combinations suitable for descriptive sensory analysis in phase II. WBS force analysis was unable to discriminate ( P > 0.05) cooking and temperature combinations among various muscles. Nine chuck muscles were then subjected to cooking by grilling, roasting, and braising to an internal temperature of 63°C and 77°C. A panel of 10 trained judges performed the descriptive analysis of the cooked chuck muscle steaks. Grilling, under medium rare conditions, was most suitable for the chuck muscles because it yielded more juiciness and roasted flavor than any other cooking method/temperature combinations. [ABSTRACT FROM AUTHOR]

Bariatric surgery induces significant and sustained weight loss and subsequently reduces obesity-related comorbidities. However, only a small percentage of patients with severe obesity undergo bariatric surgery in Denmark. There is limited knowledge about the experiences with and possible reservations to bariatric surgery among secondary healthcare providers. The aim of this cross-sectional study was to investigate referral patterns and knowledge regarding the criteria for bariatric surgery among Danish secondary healthcare providers, treating obesity-related diseases. A questionnaire regarding experiences with and reservations to referring patients for consideration for bariatric surgery, along with thoughts to specific patient cases were sent to several specialists: endocrinologists, obstetricians and gynaecologists, orthopaedic surgeons and otorhinolaryngologists. Most questions required responses on a 5-point Likert scale and frequency distributions were calculated. A total of 345 (44%) specialists responded to the questionnaires. Good knowledge of the criteria for referral to bariatric surgery varied among the specialist from 6% to 68%. One of the main issues was a concern about the medical and surgical postoperative complications, which was a barrier to and influenced referral decisions. Furthermore, specialists were more likely to refer patients to bariatric surgery when patients requested this. Except for endocrinologists, the Danish secondary healthcare specialists interviewed have limited knowledge about bariatric surgery, which results in a reluctance in referring patients. Our results indicate that there is a need to improve knowledge among specialists, regarding the indications, criteria and outcomes for bariatric surgery to establish a more pro-active, specialist led approach to referrals., (© 2020 World Obesity Federation.)

Background: There are differences in the efficacy and safety profiles of medications used to treat IBD that may impact a woman's perceived risk of medication exposure during pregnancy, potentially leading to medication non-adherence, poor disease-control and adverse pregnancy outcomes., Aim: To assess whether medication adherence patterns differ by drug class during pregnancy and influence birth outcomes for women with IBD., Methods: Of 143 491 women, a validated case definition was used to identify 370 women with IBD in five administrative health databases in Alberta, Canada (2012-2015). Women who had ≥2 consecutive medications prescription for maintenance therapy for IBD in the year prior to pregnancy were included (n = 230). Prescription-based medication possession ratio ≥0.8 defined adherence. Chi-squared tests were used to compare adherence patterns by drug class and outcomes., Results: Of the 159/230 women who were adherent during the year prior to pregnancy, 20 (12.6%; 95% CI: 8.2%, 18.8%) were not adherent and 21 (13.2%; 95% CI: 8.7%, 19.5%) discontinued their medications during pregnancy. Medication adherence during pregnancy differed significantly by drug class. A greater proportion of women on biologics (41.5%; 95% CI 32.9%, 50.7%) were adherent during pregnancy than women on thiopurines (22.9%; 95% CI 16.1%, 31.5%; P = 0.006); adherence was not significantly different for 5-aminosalicylates (35.6%; 95% CI 27.4%, 44.8%; P = 0.204). Women were more likely to be adherent to biologics (49.3%, 95% CI 37.3%, 61.3%) than thiopurines (20.9%; 95% CI 12.6%, 32.6%; P = 0.014) and 5-aminosalicylates (29.9%; 95% CI 19.9%, 42.1%; P = 0.030) in the first trimester. This was similar in the third trimester. In the second trimester, adherence pattern did not significantly differ by drug class (biologics vs thiopurines: P = 0.348; biologics vs 5-aminosalicylate: P = 0.999). Infants born to women with IBD (adherent: RR 1.58. 95% CI 1.02, 2.27; non-adherent: RR 1.32, 95% CI 0.97, 1.81) were more likely to be admitted into the neonatal intensive care unit than the general obstetric population, but this was not significantly different between women who were adherent or not adherent to their IBD medication (P = 0.711)., Conclusion: Almost a quarter of women with IBD who were previously adherent to medical therapy were not adherent during pregnancy. Adherence pattern differed by drug class., (© 2019 John Wiley & Sons Ltd.)

Objectives: This article aims to assess the contribution of genomic ancestry and socioeconomic status to obesity in a sample of admixed Latin Americans., Methods: The study comprised 6776 adult volunteers from Brazil, Chile, Colombia, Mexico, and Peru. Each volunteer completed a questionnaire about socioeconomic variables. Anthropometric variables such as weight, height, waist, and hip circumference were measured to calculate body indices: body mass index, waist-to-hip ratio and waist-to-height ratio (WHtR). Genetic data were extracted from blood samples, and ancestry was estimated using chip genotypes. Multiple linear regression was used to evaluate the relationship between the indices and ancestry, educational level, and economic well-being. The body indices were dichotomized to obesity indices by using appropriate thresholds. Odds ratios were calculated for each obesity index., Results: The sample showed high percentages of obesity by all measurements. However, indices did not overlap consistently when classifying obesity. WHtR resulted in the highest prevalence of obesity. Overall, women with low education level and men with high economic wellness were more likely to be obese. American ancestry was statistically associated with obesity indices, although to a lesser extent than socioeconomic variables., Conclusions: The proportion of obesity was heavily dependent on the index and the population. Genomic ancestry has a significant influence on the anthropometric measurements, especially on central adiposity. As a whole, we detected a large interpopulation variation that suggests that better approaches to overweight and obesity phenotypes are needed in order to obtain more precise reference values., (© 2019 Wiley Periodicals, Inc.)

Objectives: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans., Materials and Methods: We characterized a sample from Colombia (N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome-wide SNP data. We tested for correlation between dental traits, genetic ancestry, age, and sex. We carried out a biodistance analysis between the Colombian sample and reference continental population samples using the mean measure of divergence statistic calculated from dental trait frequencies. We evaluated the inference of genetic ancestry from dental traits using a regression approach (with 10-fold cross-validation) as well as by testing the correlation between estimates of ancestry obtained from genetic and dental data., Results: Latin Americans show intermediate dental trait frequencies when compared to Native Americans, Europeans, and Africans. Significant correlations were observed for several dental traits, genetic ancestry, age, and sex. The biodistance analysis displayed a closer relationship of Colombians to Europeans than to Native Americans and Africans. Mean ancestry estimates obtained from the dental data are similar to the genetic estimates (Native American: 32% vs. 28%, European: 59% vs. 63%, and African: 9% vs. 9%, respectively). However, dental features provided low predictive power for genetic ancestry of individuals in both approaches tested (R 2  < 5% for all genetic ancestries across methods)., Discussion: The frequency of dental traits in Latin Americans reflects their admixed Native American, European and African ancestry and can provide reasonable average estimates of genetic ancestry. However, the accuracy of individual genetic ancestry estimates is relatively low, probably influenced by the continental differentiation of dental traits, their genetic architecture, and the distribution of genetic ancestry in the individuals examined., (© 2018 Wiley Periodicals, Inc.)

The genetic trait of lactase persistence (LP) evolved as an adaptation to milking pastoralism in the Old World and is a well-known example of positive natural selection in humans. However, the specific mechanisms conferring this selective advantage are unknown. To understand the relationship between milk drinking, LP, growth, reproduction, and survival, communities of the Coquimbo Region in Chile, with recent adoption of milking agropastoralism, were used as a model population. DNA samples and data on stature, reproduction, and diet were collected from 451 participants. Lactose tolerance tests were done on 41 of them. The European -13,910*T (rs4988235) was the only LP causative variant found, showing strong association (99.6%) with LP phenotype. Models of associations of inferred LP status and milk consumption, with fertility, mortality, height, and weight were adjusted with measures of ancestry and relatedness to control for population structure. Although we found no statistically significant effect of LP on fertility, a significant effect (P = 0.002) was observed of LP on body mass index (BMI) in males and of BMI on fertility (P = 0.003). These results fail to support a causal relationship between LP and fertility yet suggest the idea of a nutritional advantage of LP. Furthermore, the proportion of European ancestry around the genetic region of -13,910*T is significantly higher (P = 0.008) than the proportion of European ancestry genome-wide, providing evidence of recent positive selection since European-Amerindian admixture. This signature was absent in nonpastoralist Latin American populations, supporting the hypothesis of specific adaptation to milking agropastoralism in the Coquimbo communities., (© 2018 The Authors. Annals of Human Genetics published by University College London (UCL) and John Wiley & Sons Ltd.)

Objectives: The scoring and analysis of dental nonmetric traits are predominantly accomplished by using the Arizona State University Dental Anthropology System (ASUDAS), a standard protocol based on strict definitions and three-dimensional dental plaques. However, visual scoring, even when controlled by strict definitions of features, visual reference, and the experience of the observer, includes an unavoidable part of subjectivity. In this methodological contribution, we propose a new quantitative geometric morphometric approach to quickly and efficiently assess the variation of shoveling in modern human maxillary central incisors (UI1)., Materials and Methods: We analyzed 87 modern human UI1s by means of virtual imaging and the ASU-UI1 dental plaque grades using geometric morphometrics by placing semilandmarks on the labial crown aspect. The modern human sample was composed of individuals from Europe, Africa, and Asia and included representatives of all seven grades defined by the ASUDAS method., Results: Our results highlighted some limitations in the use of the current UI1 ASUDAS plaque, indicating that it did not necessarily represent an objective gradient of expression of a nonmetric tooth feature. Rating of shoveling tended to be more prone to intra- and interobserver bias for the highest grades. In addition, our analyses suggest that the observers were strongly influenced by the depth of the lingual crown aspect when assessing the shoveling., Discussion: In this context, our results provide a reliable and reproducible framework reinforced by statistical results supporting the fact that open scale numerical measurements can complement the ASUDAS method., (© 2018 Wiley Periodicals, Inc.)

Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise., (© 2015 Wiley Periodicals, Inc.)