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The current work deals with the mixed micellization phenomena of surface active promazine hydrochloride (PMZ) drug with cationic hydrotropes (para-toluidine hydrochloride and ortho-toluidine hydrochloride) in absence and occurrence of 50 mmol kg 1 NaCl at five different temperature (293.15-313.15 K). PMZ is an amphiphilic phenothiazine drug and employed for the cure of mania and schizophrenia. Conductometry measurement was employed to gain a detailed picture of the interactions between drug and hydrotrope molecules. The experimental data were analyzed according to different mixing models within the outline of the pseudophase separation model. The evaluated values of critical micelle concentration (cmc) were found to be inferior than cmcid values signifying attractive interactions involving the both components in the solutions. NaCl further reduces the cmc of pure amphiphiles and their mixed systems as a result of screening of the electrostatic repulsion between the polar head groups. The micellar mole fractions (X1) of hydrotropes evaluated by various proposed models were constantly more than ideal values (Xid 1) signifying high involvements of hydrotrope in mixed micelles. Activity coefficients (fRub 1 and fRub 2) were always below one in all cases signifying synergism in mixed micelles. Thermodynamic parameters favor the process of micellization which is found to be entropy driven. The negative values of free energies of mixing demonstrated the stability of the mixed systems of drug and hydrotrope. [ABSTRACT FROM AUTHOR]

The electrooxidation of ethanol and acetaldehyde on Pt/C has been studied by using in situ IR spectroscopy. To identify the species formed during the electrooxidation reactions accurately, the IR spectra were collected in both HClO4/H2O and HClO4/D2O electrolytes. The results shown herein reveal that ethanol adsorbs on Pt at low potentials in a series of dehydrogenative steps that lead to η2-acetaldehyde prior to the scission of the C−C bond, which takes place at potentials higher than 150 mV. At potentials of approximately 220 mV, the Pt surface is fully covered by COad (and C1,ad) species, which thus impede further ethanol adsorption. At higher potentials, when OHad species are nucleated, COad is oxidized to CO2, which releases Pt sites for further ethanol adsorption and oxidation. However, due to the presence of OHad species, ethanol oxidation to acetic acid is the preferred reaction pathway. In contrast, the C−C bond of acetaldehyde is broken at 50 mV, which leads to the formation of a full monolayer of CO and CH x adsorbed species on Pt. The IR spectra collected in an electrolyte that contained D2O show no evidence for the formation of acetyl species prior to the scission of the C−C bond. [ABSTRACT FROM AUTHOR]

Unprotected S-acylated cysteine isopeptides containing α-, β- or γ-amino acid units have been synthesized, and their conversion to native hexapeptides by S- to the N-terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations. [ABSTRACT FROM AUTHOR]

The article demonstrates the application of graphene flakes (GFs) as supercapacitors. It discusses the preparation of electrode materials by hydrothermal synthesis. It reports that GFs synthesized through chlorosulfonic acid and hydrogen peroxide exfoliation have been successfully used to synthesize a manganese oxide/GF (MG) composite. It adds that GFs exhibit good conductivity and inhibit the aggregation of the manganese oxide nanosheets.

The article focuses on construction of graphene-based ternary organic-inorganic nanocomposites of Porphyrin which is aid by graphene oxide reduction (GO) as it is cheap and produces large-scale reduced graphene oxide (RGO). Porphyrin (P) with Tin (Sn) works as an effective photocatalyst for the reduction of graphene oxide (GO) under visible-light irradiation. It states the photoreduction of gold (Au) catalyzed by Sn-porphyrin (SnP) leads to ternary angular gold (Au) nanoparticles (AuNPs).

Nanocomposites of Ag/TiO2 nanowires with enhanced photoelectrochemical performance have been prepared by a facile solvothermal synthesis of TiO2 nanowires and subsequent photoreduction of Ag+ ions to Ag nanoparticles (AgNPs) on the TiO2 nanowires. The as-prepared nanocomposites exhibited significantly improved cathodic photocurrent responses under visible-light illumination, which is attributed to the local electric field enhancement of plasmon resonance effect near the TiO2 surface rather than by the direct transfer of charge between the two materials. The visible-light-driven photocatalytic performance of these nanocomposites in the degradation of methylene blue dye was also studied, and the observed improvement in photocatalytic activity is associated with the extended light absorption range and efficient charge separation due to surface plasmon resonance effect of AgNPs. [ABSTRACT FROM AUTHOR]

This study demonstrates the first synthesis of novel organic/inorganic ternary nanohybrids of tin(IV) prophyrin (SnPor), Ag nanoparticles (AgNPs), and reduced graphene oxide (RGO) by an environmentally friendly phtotcatalytic process using SnPor as a photocatalyst for the reduction of both GO and AgI. The nanohybrids exhibit high photocurrent generation as a result of the photosensitization effect of SnPor and surface plasmon resonance excitation in the AgNPs. Furthermore, in the activity test, the nanohybrids show good catalytic activity in the degradation of rhodamine B under the irradiation of visible light (λ>400 nm) and in the reduction of 4-nitrophenol. The detailed mechanism is discussed in the article. [ABSTRACT FROM AUTHOR]

The article focuses on fast and sensitive colorimetric detection of H[2]O[2] and glucose on the based on polyoxometalate clusters. It states that the application of colorimetric assay to glucose detection both in buffer solution and diluted serum showed that silicotungstic acid (HSiW) catalyzes the oxidation of tetramethylbenzidine (TMB) by H2O2. It also states that this detection system is simple, fast, sensitive, and selective.

In the title mol-ecule, C(12)H(12)N(2)O, the five- and six-membered rings form a dihedral angle of 68.41 (16)°. The aldehyde group is nearly coplanar with the pyrazole ring [C-C-C-O torsion angle = -0.4 (5)°]. The three-dimensional architecture is sustained by weak C-H⋯O and C-H⋯π inter-actions.

In the title compound, C(20)H(13)N(3)S, the partially saturated ring adopts a twisted half-boat conformation with the methyl-ene C atom closest to the amino-benzene ring lying 0.690 (6) Å out of the plane defined by the five remaining atoms. The dihydro-phenanthrene residue has a folded conformation [dihedral angle between the outer benzene rings = 26.27 (18)°]. The thio-phen-2-yl ring forms a dihedral angle of 63.76 (19)° with the benzene ring to which it is attached. In the crystal, inversion dimers linked by pairs of N-H⋯N hydrogen bonds generate R(2) (2)(12) loops. The dimers are linked into layers in the bc plane by weak C-H⋯π inter-actions. The thio-phen-2-yl ring is disordered over two essentially coplanar but opposite orientations in a 0.918 (4):0.082 (4) ratio.

The title mol-ecule, C(11)H(15)N(3)O(2)S, features a five-membered ring which is twisted about the middle CH(2)-CH(2) bond. The benzene ring is inclined with respect to the imine residue [C-N-N-C torsion angle = 165.4 (2)°]. Supra-molecular layers in the bc plane are formed by hydrogen bonds between the amine H atoms and sulfonamide O and imine N atoms, as well as by a weak hydrazine H-atom inter-molecular inter-action with the second sulfonamide O atom.

In the title mol-ecule, C(13)H(16)N(2)O(2)S, the nine non-H atoms comprising the indole residue are approximately coplanar (r.m.s. deviation = 0.031 Å). The partially saturated ring adopts a chair conformation. One amine H forms an inter-molecular N-H⋯O hydrogen bond to a sulfonamide O atom, while the other amine H form is connected to the indole N atom of an adjacent mol-ecule via an N-H⋯N hydrogen bond, resulting in a three-dimensional architecture.

A twist is evident in the title compound, C(21)H(21)N(3)O(2), the dihedral angle between the terminal six-membered rings being 29.46 (10)°; the linked five- and six-membered rings are coplanar [1.30 (11)°]. The carbonyl O atom accepts intra-molecular hydrogen bonds from the adjacent hy-droxy and amine groups. The three-dimensional crystal packing is achieved through C-H⋯π inter-actions.

In the title compound, C(20)H(16)N(2)O, an intra-molecular C-H⋯N forms an S(6) ring motif. In the crystal, the mol-ecules are stacked with their anthracene ring planes in sheets along [100].

In the title compound, C(21)H(16)N(2)O(2), the five-membered heterocyclic ring makes a dihedral angle of 47.06 (6)° with the attached benzene ring, whereas the indan-1,3-dione ring system and the benzene ring are oriented at a dihedral angle of 21.92 (7)°. In the crystal, inversion dimers linked by pairs of C-H⋯O hydrogen bonds generate R(2) (2)(22) loops. Aromatic π-π stacking inter-actions [centroid-centroid distances = 3.8325 (12)-3.8600 (12) Å] also occur.

In the title compound, C(15)H(13)NO(3)S, the benzene ring and the five-membered heterocyclic ring are oriented at a dihedral angle of 12.00 (6)°. In the crystal, C-H⋯O inter-actions generate two types of cyclic motifs, R(2) (2)(14) and R(2) (2)(26), connecting the mol-ecules into tapes extending along [101]. In addition, there are π-π stacking inter-actions between the benzene and thio-phene rings with centroid-centroid distances of 3.7263 (14) and 3.7487 (14) Å.

The asymmetric unit of the 1:19 title co-crystal of 2-amino-4-(3,4-dimeth-oxy-phen-yl)-5,6-dihydro-benzo[h]quinoline-3-carbo-nitrile and 3-amino-1-(3,4-dimeth-oxy-phen-yl)-9,10-dihydro-phenanthrene-2,4-dicarbonitrile, 0.05C(22)H(19)N(3)O(2)·0.95C(24)H(19)N(3)O(2), has the atoms of the fused-ring system and those of the amino, cyano and dimeth-oxy-phenyl substitutents overlapped. The fused-ring system is buckled owing to the ethyl-ene linkage in the central ring with the two flanking aromatic rings being twisted by 31.9 (1)°. The ring of the dimeth-oxy-phenyl substituent is twisted by 72.4 (1)° relative to the amino- and cyano-bearing aromatic ring. In the crystal, mol-ecules are linked by duplex amine N-H⋯O(meth-oxy) hydrogen bonds in a cyclic association [graph-set R(2) (2)(7)], generating a helical chain structure extending along [201].

The asymmetric unit of the 1:4 title co-crystal of 2-amino-4-(4-chloro-phen-yl)-5,6-dihydro-benzo[h]quinoline-3-carbonitrile and 3-amino-1-(4-chloro-phen-yl)-9,10-dihydro-phenanthrene-2,4-dicarbonitrile, 0.2C(20)H(14)ClN(3)·0.8C(22)H(14)ClN(3), has the atoms of the fused-ring system and those of the amino, cyano and chloro-phenyl substitutents overlapped. The fused-ring system is buckled owing to the ethyl-ene linkage in the central ring. There are two independent overlapped mol-ecules in the asymmetric unit. In one independent mol-ecule, the two flanking aromatic rings are twisted by 24.4 (1)° and the ring of the chloro-phenyl substituent is twisted by 87.3 (1)° relative to the amino- and cyano-bearing aromatic ring. In the second mol-ecule, the respective dihedral angles are 26.1 (1) and 57.8 (1)°. The two independent mol-ecules are linked by N-H⋯N hydrogen bonds into dimers.

The asymmetric unit of the 5:3 title co-crystal of 2-amino-4-phenyl-5,6-dihydro-benzo[h]quinoline-3-carbonitrile and 3-amino-1-phenyl-9,10-dihydro-phenanthrene-2,4-dicarbonitrile, 0.625C(20)H(15)N(3).0.375C(22)H(15)N(3), has the atoms of the fused-ring system and those of the amino, cyano and phenyl substitutents overlapped. The fused-ring system is buckled owing to the ethyl-ene linkage in the central ring, the two flanking aromatic rings being twisted by 20.1 (1)°. This ethyl-ene portion is disordered over two positions in a 1:1 ratio. The phenyl ring is twisted by 69.5 (1)° relative to the amino- and cyano-bearing aromatic ring. In the crystal, two mol-ecules are linked by an N-H⋯N hydrogen bond, generating a a helical chain along [010].

The six-membered N-heterocyclic ring of title compound, C(17)H(17)ClN(2)O, is fused with a methyl-substituted cyclo-hexene ring. The nitro-gen-bearing ring has an envelope conformation with the benzene ring-bearing C atom lying 0.432 (6) Å out of the plane defined by the other five atoms (r.m.s. deviation 0.011 Å); its benzene substituent is aligned at 84.7 (1)° to the latter plane. The cyclo-hexene ring adopts a half-chair conformation. In the crystal, two mol-ecules are linked about a center of inversion by pairs of N-H⋯O hydrogen bonds, generating dimers. An ethyl-ene portion is disordered over two orientations in a 1:1 ratio. The crystal studied was a non-merohedral twin with a 15.3 (1)% minor component.

The asymmetric unit of the diamine compound, C(18)H(14)F(3)N(2)O(2)S(2), consists of two mol-ecules; the C=C double bond has a Z configuration in the C(4)H(3)S-C=C-C(=O)-C segment. The -NH-CH(2)-CH(2)-NH chain adopts a twisted U-shape. The amino group is an intra-molecular hydrogen-bond donor to the carbonyl group; the intra-molecular hydrogen bond generates a six-membered ring. In both mol-ecules, the thienyl rings are disordered over two positions; the occupancies of the major components are 0.817 (4) and 0.778 (4) in one mol-ecule and 0.960 (4) and 0.665 (4) in the other. One of the trifluoro-methyl groups is disordered over two positions with the major component having 0.637 (8) occupancy.

The asymmetric unit of the title compound, C(17)H(13)N(3), contains two independent mol-ecules, which are non-planar as they are buckled owing to the ethyl-ene portion. The dihedral angle between the benzene rings is 26.4 (1)° in one mol-ecule and 32.9 (1)° in the other. In the crystal, the mol-ecules are disposed about a false inversion center, and are linked by two N-H⋯N hydrogen bonds, generating a dimer. The dimers are linked by further N-H⋯N hydrogen bonds, resulting in a chain that runs along the longest axis of the ortho-rhom-bic unit cell.

In the title mol-ecule, C(22)H(16)N(2)O, the phenyl ring is twisted slightly with respect to the plane of the central pyrazole ring [dihedral angle = 14.8 (2)°]; the central ring is connected to the naphthyl ring through a -CH=CH-C(=O)- fragment, whose C=C double bond has an E configuration. The pyrazole ring and naphthalene ring system are twisted by 46.3 (1)°. Weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules, forming supra-molecular chains running along the a axis. The crystal studied was a non-merohedral twin with a component ratio of 0.544 (2):0.456 (2).

In the title compound, C(22)H(14)BrN(3), the fused-ring system is buckled owing to the ethyl-ene linkage in the central ring; the two flanking aromatic rings are twisted by 25.9 (1) ° with respect to each other. The phenyl ring is twisted by 77.0 (1)° relative to the amino- and cyano-bearing aromatic ring. In the crystal, adjacent mol-ecules are linked by two N-H⋯N hydrogen bonds, generating a zigzag chain along [101].

The six-membered N-heterocyclic ring of the title compound, C(17)H(15)ClN(2)O, is fused with a methyl-substituted cyclo-hexene ring. The approximately planar nitro-gen-bearing ring (r.m.s. deviation 0.019 Å) is aromatic, and the N atom shows a trigonal-planar coordination; its benzene substituent is aligned at 77.1 (1) °. The cyclo-hexene ring adopts a half-chair conformation. In the crystal, inversion-related mol-ecules are linked by pairs of N-H⋯O hydrogen bonds, generating dimers.

In the mol-ecule of the title compound, C(20)H(13)BrN(2)O, the tetra-hydro-benzo[h]quinoline fused-ring system is buckled owing to the ethyl-ene -CH(2)CH(2)- fragment, the benzene ring and the pyridine ring being twisted by 17.7 (1)°. The 4-substituted aromatic ring is bent away from the pyridine ring by 82.3 (1)° in order to avoid crowding the cyanide substituent. Two mol-ecules are linked by a pair of N-H⋯O hydrogen bonds to form a centrosymmetric dimer.

The exocyclic C=C double-bond in the title compound, C(11)H(12)OS, has an E configuration. The methyl-bearing C atom in the cyclo-pentane ring is disordered over two positions with a site-occupation factor of 0.899 (8) for the major occupied site.

The central residue in the title compound, C(21)H(21)N(3)O(3), is close to planar (r.m.s. deviation = 0.0753 Å for all non-H atoms from OH to NH inclusive): the hy-droxy, amino and carbonyl groups all lie to the same side of the mol-ecule (the conformation about the ethene bond is Z), facilitating the formation of intra-molecular O-H⋯O and N-H⋯O hydrogen bonds that close S(6) rings. However, overall the mol-ecule is twisted as the terminal aromatic rings are not coplanar with the central plane [dihedral angles = 20.55 (5) and 80.90 (4)° for the N-bound phenyl ring and the meth-oxy-benzene ring, respectively]. The dihedral angle between the rings is 82.14 (7)°. Supra-molecular layers in the ac plane mediated by C-H⋯π inter-actions are found in the crystal.

The title compound, C(21)H(20)N(3)O(3)S(2)·CH(3)CH(2)OH, comprises two independent organic mol-ecules and two ethanol solvent mol-ecules. The mol-ecules are related by pseudo-mirror symmetry. In both mol-ecules, the N-bound benzene ring is twisted out of the plane of the pyrazole ring [the dihedral angles are 51.4 (3) and 44.1 (3)°, respectively]. Similarly, the benzene ring of the 1,2-dihydro-naphthalene residue is inclined with respect to the five-membered ring [dihedral angles 18.3 (3) and 22.2 (3)°]. Overall, each mol-ecule has a flattened U shape. Dimeric aggregates mediated by O-H⋯N(pyrazole) and amide-N-H⋯O hydrogen bonds feature in the crystal packing, whereby the ethanol mol-ecules link the independent organic mol-ecules, leading to four-mol-ecule aggregates.

Mol-ecules of the title compound, C(14)H(16)N(2)S(2), have a centre of inversion in the middle of the -CH(2)-CH(2)- bond; the (C(4)H(3)S)(CH(3))C=N-CH(2)- moiety is almost planar (r.m.s. deviation for non-H atoms 0.027 Å).

In the title compound, C(23)H(17)N(3)O, significant deviations from planarity are evidenced. This is quanti-fied in the dihedral angles formed between the central amino-benzene ring and the benzene rings of the meth-oxy-benzene [67.93 (8)°] and 1,2-dihydro-naphthalene [28.27 (8)°] residues. In the crystal the amino-H atoms form hydrogen bonds to the meth-oxy-O atom and to one of the cyano-N atoms to generate a two-dimensional array with a zigzag topology that stacks along the ([Formula: see text][Formula: see text] 1) plane.

In the mol-ecule of the title compound, C(21)H(16)N(2)O(2), the tetra-hydro-benzo[h]quinoline fused-ring system is buckled owing to the ethyl-ene -CH(2)CH(2)- fragment, the benzene ring and the pyridine ring being twisted by 19.7 (1)°. The 4-substituted aromatic ring is bent away from the pyridine ring by 50.3 (1)° in order to avoid crowding the cyanide substituent. In the crystal, two mol-ecules are linked by a pair of N-H⋯O hydrogen bonds to form a centrosymmetric dimer.

In the mol-ecule of the title compound, C(21)H(14)N(2)O(3), the tetra-hydro-benzo[h]quinoline fused-ring system is buckled owing to the ethyl-ene -CH(2)CH(2)- fragment, the benzene ring and the pyridine ring being twisted by 24.3 (1)°. The ring of the benzodioxol system is bent away from the pyridine ring by 61.4 (1)° in order to avoid crowding the cyanide substituent. Two mol-ecules are linked by a pair of N-H⋯O hydrogen bonds to form a centrosymmetric dimer.

The 15 non-H atoms of the title compound, C(11)H(12)N(2)O(2), are approximately coplanar, the r.m.s. deviation being 0.145 Å. The major deviation from coplanarity is seen in a twist between the ethene (E configuration) and pyrrole rings [C-C-N-C torsion angle = -8.26 (18)°]. The carbonyl O and cyano N atoms are syn to each other. In the crystal, supra-molecular linear tapes linked by C-H⋯O and C-H⋯N inter-actions are further connected by C-H⋯π(pyrrole) inter-actions.

The nine-membered fused-ring system of the title pyridazine derivative, C(13)H(12)N(4)O(4)S, is approximately planar (r.m.s. deviation 0.027 Å), and the benzene ring of the phenyl-sulfamide substituent is aligned at 43.5 (1)° to the fused-ring system. The amine group of the sulfonamide substituent forms an N-H⋯O hydrogen bond to the ketonic O atom of two neigboring mol-ecules to generate a chain running along the c axis.

The two aromatic rings of the title compound, C(11)H(13)N(3)O(2)S, are inclined at an angle of 47.81 (4)°. The N atom of the amino unit is pyramidally coordinated; one H atom inter-acts with the sulfamyl O atom of an adjacent mol-ecule, forming a centrosymmetric hydrogen-bonded dimer. The dimers are linked by N-H⋯N hydrogen bonds, generating a three-dimensional network.

The nine-membered fused-ring system of the title pyridazine derivative, C(7)H(7)N(3)OS, is almost planar (r.m.s. deviation 0.012 Å). In the crystal, the amino H atom forms a hydrogen bond to the ketonic O atom of a neighboring mol-ecule to generate a centrosymmetric dimer.

In the mol-ecule of the title compound, C(20)H(14)N(2)O, the tetra-hydro-benzo[h]quinoline fused-ring system is buckled owing to the ethyl-ene -CH(2)CH(2)- fragment, the benzene ring and the pyridine ring being twisted by 19.7 (1)°. The 4-substituted aromatic ring is bent away from the pyridine ring by 62.9 (1)° in order to avoid crowding the cyanide substituent. In the crystal, two mol-ecules are linked by a pair of N-H⋯O hydrogen bonds to form a centrosymmetric dimer.

In the title compound, C(18)H(17)N(3)O(2)S, the aromatic ring bearing the sulfamide unit is aligned at 61.65 (1)° with respect to the pyrrole ring; its amino group forms N-H⋯N and N-H⋯O hydrogen bonds to neighboring mol-ecules, generating sheets in the ac plane.

The complete mol-ecule of the title compound, C(18)H(22)N(4)O(6), is generated by the application of a twofold axis of symmetry. Twists are evident in the mol-ecule, i.e. between each -C=N-N group and the adjacent oxazole ring [dihedral angle = 46.08 (12) °] and between the latter and attached ester group [excluding the terminal methyl group; dihedral angle = 24.4 (7) °]. In the crystal, C-H⋯O and π-π [3.5990 (11) Å] contacts connect mol-ecules into supra-molecular arrays in the ac plane. These stack along the b axis, being connected by weak π-π [3.3903 (11) Å] inter-actions.

The five-membered dihydro-pyrazole ring in the title compound, C(10)H(9)F(3)N(2)O, is approximately planar (r.m.s. deviation 0.111 Å for all non-H atoms) and its phenyl substituent is aligned at an angle of 14.7 (2)°. Adjacent mol-ecules are linked by N-H⋯O and O-H⋯N hydrogen bonds, generating ribbons running along the b axis of the monoclinic unit cell.

In the title compound, C(20)H(19)N(5)O(3)S·H(2)O, the pyrazole ring is connected to a pyrazolone ring, and the two five-membered rings are aligned at 45.0 (1)°. The pyrazole ring is connected to a phenyl ring and the two are twisted by 42.7 (1)°. Finally, the pyrazolone ring is connected to a benzene ring and the two are twisted by 19.5 (1)°. The N-H and -NH(2) portions and the solvent water mol-ecules are engaged in N-H⋯N, N-H⋯O and O-H⋯O hydrogen-bonding inter-actions to generate a three-dimensional network.

The five-membed ring of the title compound, C(11)H(13)NO, that is fused with the aromatic ring is approximately planar (r.m.s. deviation = 0.037 Å) despite the presence of the sp(3)-hybrid-ized ethyl-ene linkage. The hy-droxy group of the N-bound hy-droxy-ethyl chain serves as hydrogen-bond donor to the azomethine N atom of an adjacent mol-ecule, generating a hydrogen-bonded C(2)-symmetric dimer.

The mol-ecule of the title compound, C(8)H(6)N(2)OS(2), has a V shape with two five-membered rings attached to a methyl-ene C atom. All non-H atoms are approximately coplanar (r.m.s. deviation = 0.096 Å). In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds into layers. The thio-phene ring is disordered over two positions; the major orientation has an occupancy of 0.683 (3). is there an intramolecular N---H...S bond?

In the mol-ecule of the title compound, C(18)H(12)N(2)OS, the tetra-hydro-benzo[h]quinoline fused-ring system is buckled owing to the ethyl-ene -CH(2)CH(2)- fragment, the benzene ring and the pyridine ring being twisted by 16.0 (1)°. The 4-substituted aromatic ring is bent away from the pyridine ring by 59.5 (2)° (for the major disordered thienyl component) in order to avoid crowding the cyanide substituent. In the crystal, two mol-ecules are linked by a pair of N-H⋯O hydrogen bonds to form a centrosymmetric dimer. The thienyl ring is disordered over two sites in a 72.7 (2):27.3 ratio.