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Lung cancer is the leading global cause of cancer‐related death, however, resistance to chemotherapy drugs remains a huge barrier to effective treatment. The elevated recruitment of myeloid derived suppressor cells (MDSCs) to tumour after chemotherapy has been linked to resistance of chemotherapy drugs. Nevertheless, the specific mechanism remains unclear. oxPAPC is a bioactive principal component of minimally modified low‐density lipoproteins and regulates inflammatory response. In this work, we found that cisplatin, oxaliplatin and ADM all increased oxPAPC release in tumour. Treating macrophages with oxPAPC in vitro stimulated the secretion of MCP‐1 and LTB4, which strongly induced monocytes and neutrophils chemotaxis, respectively. Injection of oxPAPC in vivo significantly upregulated the percentage of MDSCs in tumour microenvironment (TME) of wild‐type LL2 tumour‐bearing mice, but not CCL2−/− mice and LTB4R−/− mice. Critically, oxPAPC acted as a pro‐tumor factor in LL2 tumour model. Indeed, cisplatin increased oxPAPC level in tumour tissues of WT mice, CCL2−/− and LTB4R−/− mice, but caused increased infiltration of Ly6Chigh monocytes and neutrophils only in WT LL2‐bearing mice. Collectively, our work demonstrates cisplatin treatment induces an overproduction of oxPAPC and thus recruits MDSCs infiltration to promote the tumour growth through the MCP‐1/CCL2 and LTB4/LTB4R pathways, which may restrict the effect of multiple chemotherapy. This provides evidence for a potential strategy to enhance the efficacy of multiple chemotherapeutic drugs in the treatment of lung cancer by targeting oxPAPC. [ABSTRACT FROM AUTHOR]

This study analyses and evaluates the feasibility of a harmonic filtering distribution transformer (HFDT) for a harmonic reduction in low‐voltage distribution networks. With this new‐type transformer, power quality of the distribution systems can be improved by preventing the low‐voltage‐side harmonic currents from penetrating the higher voltage side. As the physical size of available space in prefabricated substations is strictly limited, necessary low space occupying filtering techniques are needed. Therefore, an HFDT with integrated filtering inductors (IFIs) capable of being implemented in regular air‐insulated prefabricated substations is proposed. Two sets of passive filters configured by IFIs and external capacitors are employed for harmonic filtering. Two methods for estimating the inductance parameter are provided. One is the dimension‐based method and the other is the reduced‐order inductance matrix method. The relevant harmonic reduction analysis is based on simulations with a field–circuit coupling model, which consists of a three‐dimensional finite‐element electromagnetic model of an HFDT with IFIs and a corresponding electric circuit of a simplified distribution network. These simulations prove that the described HFDT can effectively reduce specific harmonic currents with IFI‐based filters. Finally, the successful suppression of harmonics is demonstrated and discussed based on field‐test measurements. [ABSTRACT FROM AUTHOR]