1. Effect of intradialytic resistance training on pulse wave velocity and associated cardiovascular disease biomarkers in end stage renal disease.
- Author
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Chan, Danwin, Green, Simon, Fiatarone Singh, Maria A, Barnard, Robert, Bonder, Claudine S, and Cheema, Birinder S
- Subjects
CARDIOVASCULAR diseases ,CHRONIC kidney failure ,HEMODIALYSIS ,PROGENITOR cells ,BLOOD pressure - Abstract
Aims: Cardiovascular disease (CVD) is the leading cause of mortality in patients with end‐stage renal disease (ESRD) receiving maintenance haemodialysis treatment. This study investigated the effect of a 12‐week intradialytic progressive resistance training (PRT) intervention on pulse wave velocity (PWV) and associated haemodynamic, anthropometric, and hematologic outcomes in patients with ESRD. Methods: Twenty‐two patients with ESRD (59% men, 71.3 ± 11.0 years) were recruited. Supervised PRT (three sets of 11 exercises) was prescribed three times per week during routine dialysis. The primary outcome was brachial‐ankle PWV via applanation tonometry. Secondary outcomes included augmentation index, brachial and aortic blood pressures, endothelial progenitor cells, C‐reactive protein, blood lipids and anthropometrics. Results: The intradialytic PRT regimen resulted in no significant change in PWV between control and intervention periods [mean difference = 0 (95% CI = −0.1 to 0.1); P = 0.58]. Similarly, no significant change was noted in any secondary outcome measures between the control and intervention periods. Post‐hoc analyses limited to high adherers (≥75% attendance; n = 11) did not differ from the primary analysis, indicating no dose–response effect of our intervention. Conclusion: Our 12‐week PRT intervention did not change PWV or any secondary outcomes. Future studies should determine if higher dosages of intradialytic PRT (i.e. longer duration and/or higher intensity) can be applied as a method to improve arterial stiffness to potentially reduce cardiovascular disease and associated mortality this cohort. Summary at a Glance: This crossover study examined the effects of a 12‐week supervised progressive resistance training intervention in 22 haemodialysis patients. No changes were found in brachial‐ankle pulse wave velocity or any of the secondary outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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