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Rates of sudden unexpected death in infancy have been found to occur disproportionately amongst families living in the most deprived neighbourhoods. This suggests that standard safer sleep messaging may not be effective for this population and that research is required to identify ways of working that are better associated with behavioural change in parents with children at increased risk of SUDI. In this study, we aimed to explore the behavioural change components and mechanisms of action of safer sleep interventions for families with children at increased risk of SUDI. We conducted an analysis of the literature on safer sleep interventions using the COM‐B model, Theoretical Domains Framework and Behavioural Change Technique Taxonomy. All interventions targeted parents' capability; 15 interventions targeted parents' opportunity; and six interventions targeted parents' motivation to engage in safer sleep practices. Nineteen behavioural change techniques were identified. The focus of practitioners may need to shift from solely the delivery of safer sleep information towards working with parents to understand their capability, opportunity and, in particular, motivation to engage in safer sleep practices, identified as being a key driver of behaviour in this population. [ABSTRACT FROM AUTHOR]

The following iron(II) complexes of 2,6- bis(oxazolinyl)pyridine (PyBox; LH) derivatives are reported: [Fe( LH)2][ClO4]2 ( 1); [Fe(( R)- LMe)2][ClO4]2 (( R)- 2; LMe=2,6- bis{4-methyloxazolinyl}pyridine); [Fe(( R)- LPh)2][ClO4]2 (( R)- 3) and [Fe(( R)- LPh)(( S)- LPh)][ClO4]2 (( RS)- 3; LPh=2,6- bis{4-phenyloxazolinyl}pyridine); and [Fe(( R)- L iPr)2][ClO4]2 (( R)- 4) and [Fe(( R)- L iPr)(( S)- L iPr)][ClO4]2 (( RS)- 4; L iPr=2,6- bis{4- isopropyloxazolinyl}pyridine). Solid ( R)- 3⋅MeNO2 exhibits an unusual very gradual, but discontinuous thermal spin-crossover with an approximate T [ABSTRACT FROM AUTHOR]

The influence of ligands on the spin state of a metal ion is of central importance for bioinorganic chemistry, and the production of base-metal catalysts for synthesis applications. Complexes derived from [Fe(bpp)2]2+ (bpp=2,6-di{pyrazol-1-yl}pyridine) can be high-spin, low-spin, or spin-crossover (SCO) active depending on the ligand substituents. Plots of the SCO midpoint temperature ( T [ABSTRACT FROM AUTHOR]

Chlorination of 2,6-bis(pyrazol-1-yl)pyrazine (bppz) with NaClO in acetic acid afforded 2,6-bis(4-chloropyrazol-1-yl)pyrazine ( L2Cl). 2,6-Bis(4-bromopyrazol-1-yl)pyrazine ( L2Br), 2,6-bis(4-iodopyrazol-1-yl)pyrazine ( L2I), 2,6-bis(4-methylpyrazol-1-yl)pyrazine ( L2Me), and 2,6-bis(4-nitropyrazol-1-yl)pyrazine ( L2NO2) were also prepared by reactions of the preformed 4-substituted pyrazoles with 2,6-dichloropyrazine. The reduction of L2NO2 with iron powder gave 2,6-bis(4-aminopyrazol-1-yl)pyrazine ( L2NH2) and L2I was converted into 2,6-bis[4-(phenylethynyl)pyrazol-1-yl]pyrazine ( L2CCPh) by a Sonogashira coupling reaction. The salts [Fe( L2Me)2]X2 (X- = BF4- and ClO4-) underwent thermal spin-crossover abruptly at around 200 K in one and two steps, respectively. The [Fe( L2Me)2]X2 salts exhibited different light-induced excited spin-state trapping (LIESST) behavior; the BF4- salt behaves classically [ T(LIESST) = 93 K], but the ClO4- salt undergoes a multistep LIESST relaxation. In contrast, solid [Fe( L2Cl)2][BF4]2 adopts a fixed 2:1 high/low-spin-state population that does not change with temperature below 300 K, whereas [Fe( L2Br)2][BF4]2 and [Fe( L2I)2][BF4]2 form low-spin solvated crystals that are transformed into high-spin powders on drying. The pyrazinyl group in the L2R ligands slightly stabilizes the low-spin state of the complexes, as determined by solution-phase magnetic measurements. The crystal structure of [Fe( L2CCPh)(OH2) z][BF4]2 contains a disordered mixture of six- ( z = 3) and seven-coordinate ( z = 4) iron centers. [ABSTRACT FROM AUTHOR]

The nano-oligosaccharide factor (NOSF) is a new compound aiming to promote wound closure mainly through inhibition of matrix metalloproteinase (MMP) activity. This factor is incorporated within a lipido-colloid matrix (Techonology Lipido-Colloid-NOSF matrix) and locally released in the wound. The objective of this study was to document the performance (non inferiority or superiority) of the NOSF relative to the Promogran® matrix (oxidised regenerated cellulose, ORC) effect in the local management of venous leg ulcers (VLUs). This was a 12-week, open, two-arm, multicentre, randomised study. Patients were selected if the area of their VLU [ankle brachial pressure index ≥0·80] ranged from 5 to 25 cm2 with a duration ≥3 months. Ulcers had to be free from necrotic tissue. In addition to receiving compression bandage therapy, patients were randomly allocated to either NOSF matrix or ORC treatment for 12 weeks. The VLUs were assessed on a weekly basis and wound tracings were recorded. Percentage wound relative reduction (%RR) was the primary efficacy criterion. Secondary objectives were wound absolute reduction (AR), healing rate (HR) and % of wounds with ≥40% reduction compared with baseline. A total of 117 patients were included (57 NOSF matrix and 60 ORC). Mean population age was 71·3 ± 13·5 years, body mass index was ≥30 kg/m2 in 39·3% and 15·4% were diabetics. Fifty-six per cent of the VLUs were present for >6 months, 61% were recurrent and 68% were stagnating despite appropriate care. Mean wound area at baseline was 11·2 ± 7·4 cm2. At the last evaluation, mean difference between the groups for %RR was 33·6 ± 15·0% in favour of NOSF matrix with a unilateral 95% confidence interval (CI) lower limit of 8·6% not including the null value. Therefore, a superiority of NOSF matrix effect compared with ORC was concluded ( P = 0·0059 for superiority test). The median of the wound area reduction was 61·1% and 7·7% in the NOSF matrix and control groups, respectively (per-protocol analysis), or 54·4% versus 12·9% in intent-to-treat analysis ( p = 0·0286). Median AR was 4·2 cm2 in the NOSF group and 1·0 cm2 with ORC ( P = 0·01). Median HR was −0·056 and −0·015 cm2/day in NOSF and ORC groups, respectively ( P = 0·029). By logistic regression, the NOSF versus control odds ratio to reach 40% area reduction was 2·4 (95% CI: 1·1–5·3; P = 0·026). In the oldest and largest VLUs, a strong promotion of healing effect was particularly observed in the NOSF matrix group compared with the control group. NOSF matrix is a very promising option for the local management of chronic wounds, especially for VLUs with poor healing prognosis. [ABSTRACT FROM AUTHOR]

Neutral 8-(5-iodo- n-pentyl)-3-(η5-penta­methyl­cyclo­pentadi­enyl)- arachno-3-rhoda-7,8-di­thia­undecaborane, [Rh(C5H19B8­IS2)­(C10H15)], obtained from the [ arachno-7,8-S2B9H10]− anion by treatment with I(CH2)5I followed by [Rh(C5Me5)Cl2]2 and N, N, N′, N′-tetra­methyl-1,8-di­amino­naphthalene, has the 11-vertex cluster geometry of [ arachno-7,8-S2B9H10]−, but with an {Rh(C5Me5)} unit in the 3-position instead of a {BH} unit, and with a -(CH2)5I chain attached exo to an S atom. [ABSTRACT FROM AUTHOR]

The cover image compares the molecular spin states of two diastereomers of a spin‐crossover iron(II) complex. Solution‐phase magnetic measurements show the low‐spin state of the heterochiral (meso) diastereomer is stabilized relative to its homochiral (rac) congener. This reflects a steric clash between phenyl substituents in the rac isomer, which occupies two diagonal quadrants in the molecule. The resultant twisting of the ligand conformation and metal‐coordination sphere explains the observed reduction in the ligand field. More information can be found in the Full Paper by M. A. Halcrow et al. on page 9067. [ABSTRACT FROM AUTHOR]