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Quorum sensing, an important process of bacterial communication, is involved in the development of complex behavior and expression of virulence factors that become important due to its key role in infection process. In this manuscript, docking studies were used as a preliminary screening to identify main interactions between LuxR receptor (CviR) of Chromobacterium violaceum as model and N‐acyl L‐homoserine lactones. Thus, following this approach, a library of imidazo[1,2‐a]pyridines bearing carboxamide and urea moieties was designed, evaluated on this in silico model previously validated, and synthesized to generate new potential quorum sensing inhibitors. The present article summarizes survey to develop these new molecules with potential biological activity, based on interaction analysis ligand‐receptor. [ABSTRACT FROM AUTHOR]

A practical synthesis of 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1 H)-one is described that starts from 2-chloro-4-(methylamino)nicotinaldehyde. The dihalo compound then undergoes sequential, site-selective Suzuki-Miyaura cross-coupling reactions to afford highly functionalized 1,6-naphthyridones in good yields. [ABSTRACT FROM AUTHOR]

The article presents a scientific report on the structure of 1,2,3-Trimethoxy-4-[(E)-2-phenyl-vinyl]benzene and (E,E)-1,4-bis(2,3,4-trimethoxyphenyl)buta-1,3-diene. It explains how intermolecular interstatic reactions contribute to deviation in stilbene (I). The report mentions that products such as dyes and optics are derived from stilbenes. In relation to this, cis-stilbenes when combined with combretastatin derivatives are used against a wide range of cancers.

The article presents chemical equations related to the article "Exploration of Versatile Reactions on 2-Chloro-3-nitroimidazo[1,2-a]pyridine: Expanding Structural Diversity of C2- and C3-Functionalized Imidazo[1,2-a]pyridines" by A. Tonnerre et al. published in the "Tetrahedron Letters" in 2013.

The stilbene derivative 1,2,3-trimethoxy-4-[(E)-2-phenylvinyl]benzene, C(17)H(18)O(3), (I), and its homocoupling co-product (E,E)-1,4-bis(2,3,4-trimethoxyphenyl)buta-1,3-diene, C(22)H(26)O(6), (II), both have double bonds in trans conformations in their conjugated linkages. In the structure of stilbene (I), the aromatic rings deviate significantly from coplanarity, in contrast with coproduct (II), the core of which is rigorously planar. The deviation in stilbene (I) seems to be driven by intermolecular electrostatic interactions. Diene (II) sits on a crystallographic inversion centre, which bisects the conjugated linkage.