1. Expression of Interleukin-22 in Sjögren's Syndrome: Significant Correlation with Disease Parameters.
- Author
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Lavoie, T. N., Stewart, C. M., Berg, K. M., Li, Y., and Nguyen, C. Q.
- Subjects
INTERLEUKINS ,SJOGREN'S syndrome ,AUTOIMMUNE diseases ,EXOCRINE glands ,KERATOCONJUNCTIVITIS sicca ,HYPERGAMMAGLOBULINEMIA ,RHEUMATOID factor - Abstract
Sjögren's syndrome (SS) is an autoimmune disease targeting the exocrine glands resulting in xerostomia/keratoconjunctivitis sicca. Presently, we examined the levels and clinical correlations of IL-22 in SS. Patients with SS together with normal controls were randomly selected. IL-22 was detected at significantly higher levels in sera of patients with SS. The levels of IL-22 present in sera showed statistically significant direct correlations with hyposalivation, anti-SSB, anti-SSA/SSB combined, hypergammaglobulinemia and rheumatoid factor. IL-22 showed a direct correlation with major clinical parameters. The data suggest that IL-22 plays a critical role in the development of SS, and further study is needed to examine its function in human SS. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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