1. A Structural Informatics Study on Collagen.
- Author
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Bolboaca, Sorana D. and Jäntschi, Lorentz
- Subjects
- *
COLLAGEN , *AMINO acids , *STRUCTURE-activity relationships , *DRUG design , *CHEMICAL biology - Abstract
The study integrates knowledge resulting from structure–activity relationships analysis of amino acids with respect to the characterization of α1 and α2 type I collagen chains. Specifically, 15 amino acids and 14 properties were investigated and their structure–activity relationship models were obtained. The models were integrated into a web application and were used to predict the properties of a set of six amino acids. The similarities in α1 and α2 type I collagen chains has been investigated starting from the observed and predicted properties of amino acids by using two-step cluster analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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