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Dear Editor, A 90-year-old man presented with a 1-month history of fatigue and rapidly progressive, widespread skin lesions. Axillary lymph node excisional biopsy revealed partial architecture effacement by diffuse infiltration of medium-sized cells with similar morphologic features. Skin lesions are usually the first symptom of BPDCN leading patients to seek medical advice, and without therapy, they rapidly disseminate. [Extracted from the article]

Background: Acquired perforating dermatosis (APD) comprises an uncommon group of skin disorders that develop in adulthood in association with systemic diseases. The aim of this study was to characterize clinicopathologic features and treatment outcomes in a series of patients diagnosed with APD. Methods: Retrospective study of all patients diagnosed with an APD over a 10‐year period (2009–2018) at a tertiary teaching hospital in Lisbon, Portugal. Results: Fifty‐seven patients with APD were identified. Thirty‐five patients presented lesions in multiple anatomic areas (61.4%), and the lower limbs were the most common location. Forty‐six patients reported pruritus (80.7%), which was classified as severe in 21 of them (36.8%). An underlying systemic disease was identified in 53 patients (93.0%). Diabetes mellitus (DM) and chronic kidney disease (CKD) were the most common associated systemic diseases, but psychiatric disorders, malignancies, and chronic infections were present in a significant number of patients. The combination of topical steroids with antihistamines was the most prescribed initial treatment, but only 37.8% of the patients had a complete response. Acitretin, systemic steroids, and phototherapy were the treatments associated with the best outcome. Conclusion: Acquired perforating dermatosis can be associated with many systemic disorders that have pruritus as a common factor. Chronic viral infections and an occult malignancy should be sought, particularly in the absence of DM and CKD. The management of APD is challenging and is best achieved with the control of the underlying systemic diseases. [ABSTRACT FROM AUTHOR]

As such, and considering that the disease duration was unknown, three doses were administered.1-3 Herein, we present a unique case of nodular syphilis in an 83-year-old immunocompetent patient. Negative immunochemistry studies can occur due to longstanding secondary syphilis or previous antibiotic treatment regimens.1,5 Gold-standard treatment for secondary syphilis consists in a single intramuscular injection of PB. GLO:DIF/01aug21:ijd15548-fig-0001.jpg PHOTO (COLOR): 1 Secondary syphilis, clinical picture: (a,b) Multiple violaceous to brown-colored, well-delimited scaly coalescent nodules, papules, and patches, along with erosions on the legs;. [Extracted from the article]

Psoriasis is a multifactorial disease, influenced by genetic, epigenetic, and environmental factors. The effect size for psoriasis prevalence ( I r i SP 2 sp = 0.30) indicates that UVR may account for a considerable portion (30%) of the variability in psoriasis' prevalence. Regarding the UVR data, although it is possible to use annual ambient erythemally weighted UVR as a measure of a population exposure (as done in this study), its use does not overcome the biases created by not considering the true individual UVR exposure experience, which, for most subjects, is believed to vary from 5 to 15% of the total ambient UVR. [Extracted from the article]

Trichomonas vaginalis and Mycoplasma genitalium: age-specific prevalence and disease burden in men attending a sexually transmitted infections clinic in Amsterdam, the Netherlands. Comparative prevalence of infection with Trichomonas vaginalis among men attending a sexually transmitted diseases clinic. From our clinic, TV infection in men seems to be less frequent than in the published literature.2,5 This is not related to diagnostic methods, as we routinely conduct multiplex PCR for STI diagnosis and screening. [Extracted from the article]

The high number of patients submitted to radiotherapy contrasts with the few reports of postirradiation pseudosclerodermatous panniculitis, suggesting that it is an underdiagnosed clinical entity, probably because of the low number of skin biopsies performed.[4] Postirradiation pseudosclerodermatous panniculitis is an overlooked but increasingly reported entity that must be considered in the differential diagnosis of a malignancy recurrence in an anatomic body area submitted to radiotherapy. [Extracted from the article]

Abstract: Skin cancer is among the most frequent cancers in pediatric organ transplant recipients. We report a 17‐year‐old Caucasian girl who had had a kidney transplant 6 years before and was referred to our outpatient clinic for a basal cell carcinoma of the scalp. This case emphasizes the importance of teaching sun‐protective behavior to transplant recipients and their parents and having a high index of suspicion and arrange for early referral for dermatologic care if skin changes are observed. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 38-year-old male with human immunodeficiency virus (HIV) infection and was demonstrated with median nail dystrophy in his thumb nails. It says that his nail dystrophy was considered as adverse reactions to the highly active antiretroviral therapy (HAART) used to treat his HIV infection. It adds that due to virological response of the patient to ritonavir, the dosage of the drug was reduced to 600 milligrams (mg) per day from 600 mg twice a day.