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A dioxygen‐triggered selectively difunctionalization of olefins to achieve β‐hydroxysulfones has been developed. Particularly, the mechanism of this reaction can be controlled by DABCO, which act as a single electron transfer reagent, to selectively obtain ketosulfone or hydroxysulfone. The reaction was conducted in a clean, safe, mild, and catalyst‐free conditions. Moreover, as a proof‐of‐concept, two bioactive molecules were synthesized easily using this method. [ABSTRACT FROM AUTHOR]

A catalyst‐, transition metal‐, oxidant‐free strategy for the synthesis of α‐ketoamides via an electrochemical decarboxylative acylation of isocyanides at room temperature with carbon dioxide as a sole by‐product was developed in this work. This is a simple, rapid and practical strategy under mild conditions for synthesizing highly functionalized α‐ketoamides with high atom economy. [ABSTRACT FROM AUTHOR]

Background Methods Results Conclusions TUB‐like protein 4 (TULP4) is one of the distant members of tubby family proteins, whose function remains largely unknown. In the present study, we intend to identify the role of TULP4 in schizophrenia from human samples and animal models.Whole‐exome sequencing was used to detect the four schizophrenia families collected. In different cell lines, the effects of identified variants in TULP4 gene on its expression and localization were analyzed. Knockdown models in utero and adult mice were employed to investigate the role of Tulp4 on neuronal migration and schizophrenia‐related behavior. Subsequently, co‐IP assays were used to search for proteins that interact with TULP4 and the effects of mutants on the molecular function of TULP4.For the first time, we identified five rare variants in TULP4 from schizophrenia families, of which three significantly reduced TULP4 protein expression. Knockdown the expression of Tulp4 delayed neuronal migration during embryological development and consequently triggered abnormal behaviors in adult mice, including impaired sensorimotor gating and cognitive dysfunction. Furthermore, we confirmed that TULP4 is involved in the formation of a novel E3 ligase through interaction with CUL5‐ELOB/C‐RNF7 and the three deleterious variants affected the binding amount of TULP4 and CUL5 to a certain extent.Together, we believe TULP4 plays an important role in neurodevelopment and subsequent schizophrenic‐related phenotypes through its E3 ubiquitin ligase function. [ABSTRACT FROM AUTHOR]