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Your search keyword '"Castedo, Luis"' showing total 151 results
Start Over Author "Castedo, Luis" Publisher wiley-blackwell
151 results on '"Castedo, Luis"'

1. Rhodium-Catalyzed Intramolecular [3+2+2] Cycloadditions between Alkylidenecyclopropanes, Alkynes, and Alkenes.

Author

Araya, Marisel, Gulías, Moisés, Fernández, Israel, Bhargava, Gaurav, Castedo, Luis, Mascareñas, José Luis, and López, Fernando

Subjects
RHODIUM catalysts, RING formation (Chemistry), ALKYNES, ALKENES, INTRAMOLECULAR catalysis
Abstract

A Rh-catalyzed intramolecular [3+2+2] cycloaddition is reported. The cycloaddition affords synthetically relevant 5,7,5-fused tricyclic systems of type 2 from readily available dienyne precursors. The transformation takes place with moderate or good yields, high diastereoselectivity, and total chemoselectivity. [ABSTRACT FROM AUTHOR]

Published
2014
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2. Design of Stable β-Sheet-Based Cyclic Peptide Assemblies Assisted by Metal Coordination: Selective Homo- and Heterodimer Formation.

Author

Panciera, Michele, Amorín, Manuel, Castedo, Luis, and Granja, Juan R.

Abstract

Metal-directed supramolecular construction represents one of the most powerful tools to prepare a large variety of structures and functions. The ability of metals to organize different numbers and types of ligands with a variety of geometries (linear, trigonal, octahedral, etc.) expands the supramolecular synthetic architecture. We describe here the precise construction of homo- and heterodimeric cyclic peptide entities through coordination of a metal (Pd, Au) and to β-sheet-type hydrogen-bonding interactions. The selective coordination properties of the appropriate metal allow control over the cross-strand interaction between the two-peptide strands. [ABSTRACT FROM AUTHOR]

Published
2013
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3. Gold(I)-Catalyzed Intermolecular [2+2] Cycloadditions between Allenamides and Alkenes.

Author

Faustino, Hélio, Bernal, Paloma, Castedo, Luis, López, Fernando, and Mascareñas, José L.

Abstract

3-(Propa-1,2-dien-1-yl)oxazolidin-2-one works as an efficient two-carbon partner in a variety of intermolecular gold-catalyzed [2+2] cycloadditions to alkenes. The transformation represents a simple and practical entry to highly substituted cyclobutane derivatives and takes place with complete regio- and stereocontrol. [ABSTRACT FROM AUTHOR]

Published
2012
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15. New α,γ-cyclic peptides-nanotube molecular caps using α,α-dialkylated α-amino acids.

Author

Reiriz, César, Castedo, LUIS, and Granja, Juan R.

Abstract

We report here the preparation and structural characteristics of a novel self-assembling peptide composed of alternating α,α-dialkylated α-amino and cis-4-aminocyclopent-2-enecarboxylic acids. The use of α,α-dialkylated amino acids represents a novel method to prevent the formation of extensive β-sheet-like hydrogen-bonding networks that are characteristic of peptide nanotubes. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2008
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21. Progress in type II dehydroquinase inhibitors: From concept to practice.

Author

González-Bello, Concepción and Castedo, Luis

Abstract

Scientists are concerned by an ever-increasing rise in bacterial resistance to antibiotics, particularly in diseases such as malaria, toxoplasmosis, tuberculosis, and pneumonia, where the currently used therapies become progressively less efficient. It is therefore necessary to develop new, safe, and more efficient antibiotics. Recently, the existence of the shikimic acid pathway has been demonstrated in certain parasites such as the malaria parasite. These types of parasites cause more than a million casualties per year, and their effects are particularly strong in people with a compromised immune system such as HIV patients. In such cases it is possible that inhibitors of this pathway could be active against a large variety of microorganisms responsible for the more opportunistic infections in HIV patients. Interest in this pathway has resulted in the development of a wide variety of inhibitors for the enzymes involved. This review covers recent progress made in the development of inhibitors of the third enzyme of this pathway, i.e., the type II dehydroquinase. The X-ray crystal structures of several dehydroquinases ( Streptomyces coelicolor, Mycobacterium tuberculosis, etc.) with an inhibitor bound in the active site have recently been solved. These complexes identified a number of key interactions involved in inhibitor binding and have shed light on several aspects of the catalytic mechanism. These crystal structures have also proven to be a useful tool for the design of potent and selective enzyme inhibitors, a feature that will also be discussed. © 2006 Wiley Periodicals, Inc. Med Res Rev [ABSTRACT FROM AUTHOR]

Published
2007
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