1. iPSCs: A powerful tool for skeletal muscle tissue engineering.
- Author
-
Del Carmen Ortuño-Costela M, García-López M, Cerrada V, and Gallardo ME
- Subjects
- Animals, Cell Culture Techniques methods, Humans, Induced Pluripotent Stem Cells cytology, Kruppel-Like Factor 4, Kruppel-Like Transcription Factors genetics, Kruppel-Like Transcription Factors metabolism, Muscle, Skeletal metabolism, Muscle, Skeletal physiology, Octamer Transcription Factor-3 genetics, Octamer Transcription Factor-3 metabolism, Precision Medicine methods, Proto-Oncogene Proteins c-myc genetics, Proto-Oncogene Proteins c-myc metabolism, SOXB1 Transcription Factors genetics, SOXB1 Transcription Factors metabolism, Tissue Scaffolds, Cellular Reprogramming Techniques methods, Induced Pluripotent Stem Cells metabolism, Muscle, Skeletal cytology, Regeneration physiology, Tissue Engineering methods
- Abstract
Both volumetric muscle loss (VML) and muscle degenerative diseases lead to an important decrease in skeletal muscle mass, condition that nowadays lacks an optimal treatment. This issue has driven towards an increasing interest in new strategies in tissue engineering, an emerging field that can offer very promising approaches. In addition, the discovery of induced pluripotent stem cells (iPSCs) has completely revolutionized the actual view of personalized medicine, and their utilization in skeletal muscle tissue engineering could, undoubtedly, add myriad benefits. In this review, we want to provide a general vision of the basic aspects to consider when engineering skeletal muscle tissue using iPSCs. Specifically, we will focus on the three main pillars of tissue engineering: the scaffold designing, the selection of the ideal cell source and the addition of factors that can enhance the resemblance with the native tissue., (© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.)
- Published
- 2019
- Full Text
- View/download PDF