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Herein we report the use of tetrakis (guanidinium) pyrenetetrasulfonate (G4PYR) and bis (guanidinium) 1,5‐napthalene disulfonate (G2NDS) to catalyze the cyclization of 2‐cyanobenzamide (1) to isoindolone (2). Moreover, we demonstrate the remarkable selectivity of these guanidinium organosulfonate hosts in encapsulating 2 over 1. By thoroughly investigating the intramolecular cyclization reaction, we determined that guanidinium and the organosulfonate moiety acts as the catalyst in this process. Additionally, 2 is selectively encapsulated, even in mixtures of other structurally similar heterocycles like indole. Furthermore, the tautomeric state of 2 (amino isoindolone (2–A) and imino isoindolinone forms (2–I)) can be controlled by utilizing different guanidinium organosulfonate frameworks. [ABSTRACT FROM AUTHOR]

Metal‐metal bonds have rarely been explored as active elements in supramolecular assemblies despite their unique potential to introduce responsive behavior. In this report, a dynamic molecular container composed of two cyclometalated Pt units is constructed using Pt−Pt bonds. This molecule—the flytrap—has a flexible jaw composed of two [18]crown‐6 ethers that can adapt their shape to bind large inorganic cations with sub‐micromolar affinity. Along with the spectroscopic and crystallographic characterization of the flytrap, we report its photochemical assembly, which allows the capture of ions and their transport from solution to the solid state. In addition, we have been able to recycle the flytrap to regenerate its starting material due to the reversible nature of the Pt−Pt bond. We believe that other molecular containers and materials for harvesting valuable substrates from solution could be assembled using the advances presented here. [ABSTRACT FROM AUTHOR]

Background and Purpose: The first pass effect has been reported as a mechanical thrombectomy (MT) success metric in patients with large vessel occlusive stroke. We aimed to compare the clinical and neuroimagign outcomes of patients who had favorable recanalization (mTICI 2c or mTICI 3) achieved in one pass versus those requiring multiple passes. Methods: In this "real‐world" multicenter study, patients with mTICI 2c or 3 recanalization were identified from three prospectively collected stroke databases from January 2016 to December 2019. Clinical outcomes were a favorable functional outcome at 90 days (modified Rankin Scale score 0–2), and the rate of symptomatic intracranial hemorrhage (ICH) any ICH, and 90‐day mortality. Results: Favorable recanalization was achieved in 390/664 (59%) of consecutive patients who underwent MT (age 71.2 ± 13.2 years, 188 [48.2%] women). This was achieved after a single thrombectomy pass (n = 290) or multiple thrombectomy passes (n = 100). The rate of favorable clinical outcome was higher (41% vs. 28 %, p =.02) in the first pass group with a continued trend on multivariate analysis that did not reaching statistical significance (OR 1.68 95% confidence interval [CI] 1.0–2.95, p =.07). Similarly, the odds of any ICH were significantly lower (OR 0.56 CI 0.32–0.97, p =.03). A similar trend of favorable clinical outcomes was noticed on subgroup analysis of patients with M1 occlusion (OR 1.81 CI 1.01–3.61, p =.08). Conclusion: The first‐pass reperfusion was associated with a trend toward favorable clinical outcome and lower rates of ICH. These data suggest that the first‐pass effect should be the mechanical thrombectomy procedure goal. [ABSTRACT FROM AUTHOR]

We report the synthesis, characterization, and spectroscopic investigations of a new responsive‐at‐metal cyclometalated platinum(II) complex. With mild chemical oxidants and reductants, it was possible to obtain the same complex in three different oxidation states and each of these complexes was structurally characterized by single‐crystal X‐ray diffraction. We discovered that the platinum(II) complex displays strong solvatochromism in the solid state, which can be attributed to modulation of Pt⋅⋅⋅Pt interactions that results in switching between optical and photoluminescent states. Incorporating responsive‐at‐metal species as dynamic components in nanostructured materials might facilitate response amplification, sensing, actuation, or self‐healing processes. [ABSTRACT FROM AUTHOR]

Frontispiece: Molecular Flytraps Held Together by Platinum-Platinum Intermetallic Bonds In their Communication (e202305525), Mark J. MacLachlan use a single Pt-Pt bond to glue two cyclometalated hosts together and generate a flytrap-like molecule. Keywords: Host-Guest Chemistry; Metal-Metal Bonding; Platinum; Redox; Supramolecular Chemistry EN Host-Guest Chemistry Metal-Metal Bonding Platinum Redox Supramolecular Chemistry 1 1 1 07/21/23 20230724 NES 230724 B Supramolecular Chemistry b . [Extracted from the article]

Keywords: dimers; luminescence; platinum; solvatochromism; X-ray diffraction EN dimers luminescence platinum solvatochromism X-ray diffraction 10286 10286 1 06/17/20 20200622 NES 200622 B Platin gehört die Welt b ! Die feine Modulation der Pt---Pt-Wechselwirkungen durch Lösungsmittelmoleküle führt zu starken vapochromen und solvatochromen Effekten. Dimers, luminescence, platinum, solvatochromism, X-ray diffraction. [Extracted from the article]