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Owing to unique alkyne‐rich structure, graphdiyne (GDY) has been proven to be a superb support for anchoring metal catalysts. Herein we demonstrate a new role of GDY as the wettability modifier for enhanced hydrogenation catalysis. After loading a certain amount GDY nanospheres, the silica mesoporous channels become superaerophilic, which allows gaseous H2 to be directly stored inside, thus significantly increasing the H2 concentration around the palladium nanoparticles (NPs). At the same time, GDY nanospheres also alter the electronic structure of the Pd NPs via a strong d‐π interaction. Combining these two roles of GDY, allows the hydrogenation of benzaldehyde to proceed under ambient H2 pressure in water, with an impressive 4.3‐fold enhancement compared to the unmodified Pd/mSiO2 catalyst. This study demonstrates a new role of GDY in constructing wettability matched catalysts for gas‐liquid‐solid tri‐phase reactions. [ABSTRACT FROM AUTHOR]

Owing to unique alkyne‐rich structure, graphdiyne (GDY) has been proven to be a superb support for anchoring metal catalysts. Herein we demonstrate a new role of GDY as the wettability modifier for enhanced hydrogenation catalysis. After loading a certain amount GDY nanospheres, the silica mesoporous channels become superaerophilic, which allows gaseous H2 to be directly stored inside, thus significantly increasing the H2 concentration around the palladium nanoparticles (NPs). At the same time, GDY nanospheres also alter the electronic structure of the Pd NPs via a strong d‐π interaction. Combining these two roles of GDY, allows the hydrogenation of benzaldehyde to proceed under ambient H2 pressure in water, with an impressive 4.3‐fold enhancement compared to the unmodified Pd/mSiO2 catalyst. This study demonstrates a new role of GDY in constructing wettability matched catalysts for gas‐liquid‐solid tri‐phase reactions. [ABSTRACT FROM AUTHOR]

Summary: It is an effective way to use magnetic shielding scheme in magnetic coupled wireless power transfer (WPT) system to reduce magnetic flux leakage. However, the additional shielding material would affect the equivalent circuit model and the power transmission efficiency of WPT system. Although the impact of some common shielding materials on the transmission efficiency has been studied using finite element simulation, there is still a lack of understanding about the impact to the equivalent model in theory. In this paper, the equivalent circuit and transmission efficiency of WPT system are analyzed theoretically under the influence of different shielding materials, and the relationship between material electrical characteristics and transmission efficiency is presented. In our WPT prototype with two 166‐mm diameter coils under ferrite shielding and aluminum shielding, the achieved maximum transmission efficiencies are 95.7% for 100‐kHz resonant frequency and 97.9% for 1‐MHz resonant frequency under the ferrite shielding, and the efficiency errors between the analytical and experimental results are less than 5% for 100‐kHz resonant frequency and 10% for 1‐MHz resonant frequency. The equivalent circuit and transmission efficiency of wireless power transfer system are analyzed theoretically under the influence of different shields, and the relationship between material electrical characteristics and transmission efficiency is presented. The analyzing and experimental results show that shields with high permeability and low electrical conductivity are beneficial for enhancing the transmission efficiency of WPT system. [ABSTRACT FROM AUTHOR]

Abstract: The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation. [Copyright &y& Elsevier]

Blonanserin is a novel oral antischizophrenic drug. Under fasting (n = 50) and fed (n = 60) conditions, this study compared the bioequivalence of the generic blonanserin tablet with the reference blonanserin tablet. In this single‐center, randomized, open‐label, 2‐period, 2‐sequence, crossover study, 110 patients were randomly given a 4‐mg dose of either the test or reference blonanserin tablet with a 14‐day washout period. Blood samples were taken before performing and up to 72 hours following. A validated high‐performance liquid chromatography‐tandem mass spectrometry technique was used to measure the levels of blonanserin in plasma. Safety was evaluated throughout the study. The study found no significant differences in the maximum observed drug concentration in the plasma (Cmax), the area under the plasma concentration‐time curve from time 0 to the last sampling time (AUC0‐t), and the area under the plasma concentration‐time curve from time 0 to infinity (AUC0‐∞) between the 2 blonanserin formulations. The 90% confidence intervals of the geometric mean ratio of the test/reference formulations for Cmax, AUC0‐t, and AUC0‐∞ were within the 80%‐125% limit. Food dramatically raised blonanserin exposure, and also significantly prolonged the lag time of absorption. No serious adverse events occurred. These results indicate that the 2 blonanserin formulations were bioequivalent and well tolerated in healthy Chinese subjects. In clinical treatment, it is necessary to consider the food effect of blonanserin. [ABSTRACT FROM AUTHOR]

Aims: Status epilepticus (SE) is the most common neurological emergency in pediatric patients. This study aimed to screen for prognostic biomarkers of SE in the cerebrospinal fluid (CSF) using metabolomics. Methods: Ultra‐performance liquid chromatography quadrupole time‐of‐flight tandem mass spectrometry (UPLC‐QTOF‐MS) was conducted to identify prognostic biomarkers in CSF metabolomics by comparing the poor outcome group (N = 13) with the good outcome group (N = 15) of children with SE. Differentially expressed metabolites were identified using Mann–Whitney U test corrected by Benjamini‐Hochberg and partial least squares discriminant analysis (PLS‐DA). Results: The PLS‐DA model identified and validated significant metabolic differences between the poor and good outcome groups of children with SE (PLS‐DA with R2Y = 0.992 and Q2 = 0.798). A total of 49 prognosis‐related metabolites were identified. Of these metabolites, 20 including glutamyl‐glutamine, 3‐iodothyronamine, and L‐fucose had an area under the curve (AUC) ≥ 80% in prognostic prediction of SE. The logistic regression model combining glutamyl‐glutamine and 3‐iodothyronamine produced an AUC value of 0.976, with a sensitivity of 0.863 and specificity of 0.956. Pathway analysis revealed that dysregulation of the citrate cycle (TCA) and arginine biosynthesis may contribute to poor SE prognosis. Conclusions: This study highlighted the prognosis‐related metabolomic disturbances in the CSF of children with SE and identified potential prognostic biomarkers. A prognostic prediction model combining glutamyl‐glutamine and 3‐iodothyronamine with high predictive value was established. [ABSTRACT FROM AUTHOR]

An abstract of the article "Determination of Acidolysis Hydrocarbons in Oil/Gas Geochemical Exploration Sample By Gas Chromatograph," by Chen Weiming and colleagues is presented.

In this work, the authors attempted to present a detailed study on the adsorption of bovine hemoglobin (BHB) by sulfonated polystyrene nanospheres (SPS NSs). The adsorption characteristics including adsorption isotherms, kinetics and thermodynamics were studied in detail. The adsorption isotherms were better fitted by the Langmuir model, leading to a remarkable adsorption capacity of 2831.4 mg g−1. Such an adsorption capacity is among the highest values reported in the literature. The adsorption kinetics was analyzed by the pseudo‐first‐order, pseudo‐second‐order and intra‐particle diffusion equations. The thermodynamic parameters including binding site, binding affinity, and changes of enthalpy, entropy and Gibbs free energy were determined by isothermal titration calorimetry measurements. The electrostatic interaction of BHB and SPS NSs was identified as the major adsorption mechanism. The effects of solution pH, temperature and competitive metal ions in the adsorption process were studied. Based on the Arrhenius equation, the activation energy of the adsorption process was determined to be 2.34 kJ mol−1. Sulfonated polystyrene nanospheres (SPS NSs) were used to extract bovine hemoglobin (BHB) from aqueous solutions via electrostatic interaction. The adsorption isotherms were better fitted by the Langmuir model, leading to a remarkable adsorption capacity of 2831.4 mg g−1. Such an adsorption capacity is among the highest values reported in the literature. [ABSTRACT FROM AUTHOR]