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In the presence of DIPEA (diisopropylethylamine), a formal [3+2] cycloaddition reaction between diazooxindoles and oxazol-5-(4H)-ones takes place easily to give new 3-(1H-1,2,4-triazol-1-yl)indolin-2-ones in 61-98% yield. The structure of the target molecules was confirmed by single-crystal X-ray structure analysis. [ABSTRACT FROM AUTHOR]

Aim Elevated neutrophil-to-lymphocyte ratio ( NLR) has been demonstrated to be a poor prognostic factor in multiple types of malignancies, whereas the effect of NLR on the prognosis of epidermal growth factor receptor ( EGFR)-mutated advanced non-small-cell lung cancer ( NSCLC) patients treated with first-line EGFR tyrosine kinase inhibitors ( TKIs) is not fully addressed. Methods 81 metastatic NSCLC patients harboring EGFR mutation treated with first-line EGFR TKIs were retrospectively included. The associations between baseline clinical characteristics, including NLR, and tumor response, progression and survival were investigated. Results Elevated NLR (≥3.5) was observed in 33 of 81 patients. The progression-free and overall survival of the patients with increased NLR was significantly worse than that of the patients with decreased NLR (8.20 vs 10.60 months, P < 0.001 and 17.20 vs 23.20 months, P < 0.001, respectively). Elevated NLR was confirmed to be an independent prognostic factor for worse progression-free and overall survival in Cox multivariate analysis. Conclusion Elevated NLR is likely to be associated with poor outcome in EGFR-mutated advanced NSCLC patients treated with first-line EGFR TKIs. [ABSTRACT FROM AUTHOR]

In the presence of Na2CO3, the [3+2] cycloaddition of azaoxyallyl cations, in situ formed from α-halohydroxamates by reaction with isothiocyanides, proceeded smoothly and furnished ( Z)-2-iminothiazolidin-4-ones in 25-99 % chemical yields. The chemical structure of the title compounds was confirmed by X-ray single-crystal structure analysis. [ABSTRACT FROM AUTHOR]

Catalyzed by 10 mol-% PhCO2H, the [3+2] cycloaddition between 3-isothiocyanato oxindoles and nitroso compounds proceeded readily to deliver 1,2,4-oxadiazolidine-3-thione-fused spirooxindoles in 40-82 % yield. The structures of the title compounds were firmly confirmed by X-ray single-crystal structure analysis. [ABSTRACT FROM AUTHOR]

Catalyzed by a Cinchona-based thiourea, the [3+2] cycloadditions of barbiturate-based olefins with 3-isothiocyanatooxindoles proceeded readily, and furnished dispirobarbiturates in excellent chemical yields with excellent diastereo- and enantioselectivities. The absolute configuration of dispirobarbiturates was firmly confirmed by an X-ray single crystal structure analysis. A reaction mechanism was proposed to account for the enantioselective formation of dispirobarbiturates. [ABSTRACT FROM AUTHOR]

In the presence of sodium carbonate, the [4+3] cycloadditions of α-halogeno hydrazones with nitrones were performed efficiently, and affording 2,3,4,7-tetrahydro-1,2,4,5-oxatriazepines in moderate to high yields. [ABSTRACT FROM AUTHOR]

In the presence of a Cinchona alkaloid-based squaramide organocatalyst, the [3+2] cycloaddition of isatin-derived azomethine ylides with maleimides proceeded readily, thus delivering the desired pyrrolidine-fused spirooxindoles in 61-89% yields with >20:1 dr and 12 to >99 % ee. The absolute configuration of 5-chloro-1,5′-dimethyl-3′-phenyl-3′,3a′-dihydro-2′ H-spiro[indoline-3,1′-pyrrolo[3,4- c]pyrrole]-2,4′,6′(5′ H,6a′ H)-trione was unambiguously determined by means of X-ray single crystal structure analysis. The reaction mechanism was hypothesized to account for the enantioselective formation of 5-chloro-1,5′-dimethyl-3′-phenyl-3′,3a′-dihydro-2′ H-spiro[indoline-3,1′-pyrrolo[3,4- c]pyrrole]-2,4′,6′(5′ H,6a′ H)-trione. [ABSTRACT FROM AUTHOR]

In the presence of cinchona-thiourea organocatalyst C1, the developed organocatalytic three-component cascade reaction of isatins, malononitrile, and 2-hydroxynaphthalene-1,4-diones readily proceeded to furnish chiral pyranonaphthoquinone-fused spirooxindoles in excellent chemical yields and high enantioselectivities (up to 99 % yield and 97 % ee). The absolute configurations of the spirooxindoles were assigned on the basis of an X-ray single crystal structure. Moreover, a reaction mechanism is proposed that accounts for the stereocontrolled formation of the chiral spirooxindoles,. [ABSTRACT FROM AUTHOR]

BACKGROUND: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a distinct subtype of non-Hodgkin lymphoma in which the upper aerodigestive tract is the most commonly involved site. To date, optimal treatment strategies and prognosis for patients with ENKTL have not been fully defined. METHODS: This prospective study was conducted to evaluate the efficacy and safety profiles of first-line combined gemcitabine, oxaliplatin, and L-asparaginase (GELOX) followed by involved-field radiation therapy for patients with stage IE/IIE ENKTL. The primary endpoints were the complete response rate, the objective response rate, and toxicities. Secondary endpoints were overall survival and progression-free survival. RESULTS: Twenty-seven patients with newly diagnosed ENKTL were enrolled and completed the entire course of treatment. At the end of treatment, the overall response rate was 96.3%, including 20 patients (74.1%) who attained a complete response and 6 patients (22.2%) who attained a partial response. No patients developed disease progression during therapy. Grade 1 and 2 toxicities were frequent during GELOX, but grade 3 and 4 toxicities were few, and no treatment-related deaths occurred. At a median follow-up of 27.37 months, 7 patients (25.9%) experienced disease progression, and 4 of those patients died of disease. The rates of 2-year overall and progression-free survival were both 86%, and patients who attained a complete response at the end of treatment had significantly longer progression-free survival ( P = .012) and overall survival ( P = .021) than patients who did not attain a complete response. CONCLUSIONS: The current results indicated that GELOX followed by involved-field radiation therapy can be an effective and feasible treatment strategy for patients with stage IE/IIE ENKTL of the upper aerodigestive tract. These results will require further investigation in larger prospective trials. Cancer 2013. © 2012 American Cancer Society. [ABSTRACT FROM AUTHOR]

30 examples [ABSTRACT FROM AUTHOR]

Notably, benzylamine as amine component does not react. [ABSTRACT FROM AUTHOR]